Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein

Cell

Volumn 78, Issue 5, 1994, Pages 799-811

  Fagan, Rick ^a   Flint, Kate J ^a   Jones, Nic ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

ADENOVIRUS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; DNA REPLICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; VIRUS INFECTION; VIRUS REPLICATION;

ADENOVIRIDAE;

EID: 0027936238     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(94)90522-3     Document Type: Article

References (53)

1. Adenovirus E1A can dissociate heteromeric complexes involving the E2F transcription factor a novel mechanism for E1A trans-activation
2. Functional synergy between DP-1 and E2F-1 in the cell cycle regulating transcription factor DRTF1/E2F
3. Transcription factor E2F is required for efficient overexpression of the hamster dihydrofolate reductase gene in vitro and in vivo
4. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
5. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
6. The E2F transcription factor is a cellular target for the Rb protein
7. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
8. A genetic analysis of the E2F1 gene distinguishes regulation by Rb p107 and adenovirus E4
9. Cell cycle regulation of the human cdc2 gene
10. Characterization of SAP-1 a protein recruited by serum response factor to the c-fos serum response element
11. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
12. Physical interaction of the retinoblastoma protein with human D cyclins
13. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
14. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
15. Differential regulation of three members of the ATF/Creb family of DNA-binding proteins
16. A new component of the transcription factor DRTF1/E2F1
17. The activation domain of transcription factor PU 1 binds the retinoblastoma (RB) protein and transcription factor TFIID in vitro RB shows sequence similarity to TFIID and TFIIB
18. E2F from adenovirus-infected cells binds cooperatively to DNA containing two properly orientated and spaced recognition sites
19. An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity
20. Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4
21. The retinoblastoma protein as a transcriptional repressor
22. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
23. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation
24. DMSO-enhanced whole cell yeast transformation
25. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
26. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations
27. Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection
28. Purification and characterisation of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product
29. Cloning and characterization of E2F-2 a novel protein with the biochemical properties of the transcription factor E2F
30. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product
31. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
32. Identification of a cellular transcription factor involved in E1A trans-activation
33. Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
34. DRTF1/E2F an expanding family of heterodimeric transcription factors implicated in cell-cycle control
35. The retinoblastoma protein binds to a family of E2F transcription factors
36. Cyanogen bromide cleavage and proteolytic peptide mapping of proteins immobilized to membranes
37. The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter
38. Cell cycledependent regulation of phosphorylation of the human retinoblastoma gene product
39. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells
40. E2F a link between the Rb tumor suppressor protein and viral oncoproteins
41. cdc2 and its companion cyclin-dependent kinases
42. Mitogen-activated protein kinases versatile transducers for cell signaling
43. Glycogen synthase kinase-3 functions in oncogenisis and development
44. The adenovirus E4 gene in addition to the E1A gene is important for the transactivation of E2 transcription and for E2F activation
45. Heterogeneity of adenovirus type 5 proteins multiple serine phosphorylations induce slow-migrating electrophoretic variants but do not affect E1A-induced transcriptional activation or transformation
46. A vector for expressing GAL4(1147) fusions in mammalian cells
47. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response
48. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins identification of a gene with properties of the transcription factor E2F
49. Mammalian G cyclins
50. Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated Rb protein unable to bind SV40 T antigen
51. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase
52. Promoter interaction of E1A-inducible factor E2F and its potential role in the formation of a multicomponent complex