Spirovesamicols: Conformationally Restricted Analogs of 2-(4-Phenylpiperidino)cyclohexanol (Vesamicol, AH5183) as Potential Modulators of Presynaptic Cholinergic Function

Journal of Medicinal Chemistry

Volumn 37, Issue 16, 1994, Pages 2574-2582

  Efange, S M N ^a   Khare, A B ^a   Foulon, C ^a   Akella, S K ^a   Parsons, S M ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1' (1,2,3,4 TETRAHYDRO 2 HYDROXY 3 NAPHTHYL)SPIRO[1H INDENE 1,4' PIPERIDINE]; 2 BROMO 1' (1,2,3,4 TETRAHYDRO 2 HYDROXY 3 NAPHTHYL)SPIRO[1H INDENE 1,4' PIPERIDINE]; CHOLINERGIC RECEPTOR; ETHYLENE DERIVATIVE; PROPYLENE; UNCLASSIFIED DRUG; VESAMICOL; VESAMICOL DERIVATIVE; VINYL DERIVATIVE;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC ORGAN; NERVE ENDING; NONHUMAN; PRESYNAPTIC MEMBRANE; RECEPTOR AFFINITY; SYNAPTOSOME;

ACETYLCHOLINE; ALKENES; ANIMAL; COMPARATIVE STUDY; ELECTRIC ORGAN; ETHYLENES; INDENES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEUROMUSCULAR DEPOLARIZING AGENTS; PIPERIDINES; RECEPTORS, CHOLINERGIC; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPTIC VESICLES; VINYL COMPOUNDS;

EID: 0027935474     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00042a010     Document Type: Article

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