3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus

Journal of Neurochemistry

Volumn 63, Issue 2, 1994, Pages 769-772

  Schoepp, Darryle D ^a   Goldsworthy, John ^a   Johnson, Bryan G ^a   Salhoff, Craig R ^a   Baker, S Richard ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

3,5 Dihydroxyphenylglycine; Cyclic AMP; Hippocampus; Metabotropic glutamate receptors; Phosphoinositide hydrolysis; Second messenger systems

Indexed keywords

2 (CARBOXYCYCLOPROPYL)GLYCINE; 3,5 DIHYDROXYPHENYLGLYCINE; AMINO ACID RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLOLEUCINE; METABOTROPIC RECEPTOR; PHOSPHATIDYLINOSITIDE;

ARTICLE; HIPPOCAMPUS; HYDROLYSIS; PRIORITY JOURNAL; SECOND MESSENGER;

EID: 0027934857     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1994.63020769.x     Document Type: Article

References (19)

1. Casabona G., Genazzani A. A., Di Stefano M., Sortino M. A., and Nicoletti F. (1992) Developmental changes in the modulation of cyclic AMP formation by the metabotropic glutamate receptor agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid in brain slices. J. Neurochem. 59, 1161-1163.
2. Chou T.-C. and Talalay P. (1983) Analysis of combined drug effects: a new look at a very old problem. Trends Pharmacol. Sci. 11, 450-454.
3. Christensen H. N., Handlogten M. E., Vadgama J. V., De La Cuesta E., Ballesteros P., Trigo G. G., and Avendano C. (1983) Synthesis and transport applications of 3-aminobicyclo[3.2.1]octane-3-carboxylic acids. J. Med. Chem. 26, 1374-1378.
4. Hayashi Y., Tanabe Y., Aramori I., Masu M., Shimamoto K., Ohfune Y., and Nakanishi S. (1992) Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 107, 539-543.
5. Ito I., Kohda A., Tanabe S., Hirose E., Hayashi M., Mitsunaga S., and Sugiyama H. (1992) 3,5-Dihydroxyphenylglycine: a potent agonist of metabotropic glutamate receptors. Neuroreport 3, 1013-1016.
6. 1-adrenoceptor activation. Biochem. Soc. Trans. 20, 109-113.
7. Layne E. (1957) Spectrophotometric and turbidimetric methods for measuring proteins. Methods Enzymol. 3, 447-454.
8. Martin L. J., Blackstone C. D., Huganir R. L., and Price D. L. (1992) Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron 9, 259-270.
9. Maslanski J. A. and Busa W. B. (1990) A sensitive and specific mass assay for myo-inositol and inositol phosphates, in Methods in Inositide Research (Irvine R. F., ed), pp. 113-126. Raven Press, New York.
10. Nakagawa Y., Saitoh K., Ishihara T., Ishida M., and Shinozaki H. (1990) (2S,3S,4S)α-(Carboxycyclopropyl)glycine is a novel agonist of metabotropic glutamate receptors. Eur. J. Pharmacol. 184, 205-206.
11. Nakanishi S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258, 597-603.
12. Schoepp D. D. (1994) Novel functions for subtypes of metabotropic glutamate receptors. Neurochem. Int. (in press).
13. Schoepp D. D. and Conn P. J. (1993) Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. Sci. 14, 13-20.
14. Schoepp D. D. and Johnson B. G. (1993a) Pharmacology of metabotropic glutamate receptor inhibition of cyclic AMP formation in the adult rat hippocampus. Neurochem. Int. 22, 277-283.
15. Schoepp D. D. and Johnson B. G. (1993b) Metabotropic glutamate receptor modulation of cAMP accumulation in the neonatal rat hippocampus. Neuropharmacology 32, 1359-1365.
16. Schoepp D. D., Johnson B. G., True R. A., and Monn J. A. (1991) Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis. Eur. J. Pharmacol. Mol. Pharmacol. Sect. 207, 351-353.
17. Schoepp D. D., Johnson B. G., and Monn J. A. (1992) Inhibition of cyclic AMP formation by a selective metabotropic glutamate receptor agonist. J. Neurochem. 58, 1184-1186.
18. Shigemoto R., Nomura S., Ohishi H., Sugihara H., Nakanishi S., and Mizuno N. (1993) Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci. Lett. 163, 53-57.
19. Winder D. G. and Conn P. J. (1993) Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine. J. Neurosci. 13, 38-44.