The ulceration‐associated cell lineage (UACL) reiterates the Brunner's gland differentiation programme but acquires the proliferative organization of the gastric gland

The Journal of Pathology

Volumn 173, Issue 4, 1994, Pages 317-326

  Ahnen, Dennis J ^a   Poulsom, Richard ^b   Stamp, Gordon W H ^b,c   Elia, George ^b   Pike, Christine ^b   Jeffery, Rosemary ^b   Longcroft, Janet ^b   Rio, Marie‐Christine ^d   Chambon, Pierre ^d   Wright, Nicholas A ^b,c  

^a UNIVERSITY OF COLORADO   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d INSERM   (France)

Author keywords

differentiation; EGF; Ulceration

Indexed keywords

CYCLINE; EPIDERMAL GROWTH FACTOR; PROTEIN PS2; UROGASTRONE;

ARTICLE; BRUNNER GLAND; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DIGESTIVE SYSTEM ULCER; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; METAPLASIA; PRIORITY JOURNAL;

EID: 0027934797     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1711730406     Document Type: Article

References (39)

1. Aberrant pyloric glands in regional ileitis
2. Brunner‐type glands in regional enteritis
3. Pyloric metaplasia in the small intestine
4. Induction of a novel epidermal growth factor‐secreting cell lineage by mucosal ulceration in gastrointestinal stem cells
5. Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues
6. Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract
7. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form
8. hSP, the domain‐duplicated homologue of pS2 protein, is co‐expressed with pS2 in stomach but not breast carcinoma
9. Immunohistochemical localisation of urogastrone to human duodenal and submandibular glands
10. Epidermal growth factor
11. Role of epidermal growth factor in healing of chronic gastroduodenal ulcers in rats
12. Intravenous but not intragastric urogastrone/EGF is trophic to the intestine of parenterally‐fed rats
13. Intravenous epidermal growth factor increases small intestinal cell proliferation in congenital microvillous atrophy
14. Role of EGF in regulation of gastric secretion
15. Epidermal growth factor receptor in the intestinal enterocyte. Localisation to laterobasal but not brush border membranes
16. On the role of epidermal growth factor in the defence of the gastroduodenal mucosa
17. Intravenous and subcutaneous pharmacokinetics and rectal bioavailability of epidermal growth factor in the presence of absorption promoter in rats
18. The epidermal growth factor family
19. Immunoreactivities for epidermal growth factor (EGF) and for EGF receptors in rats with gastric ulcers
20. Cloning of cDNA sequences of hormone related genes from the MCF‐7 human breast cancer cell line
21. Breast cancer associated pS2 protein synthesis and secretion by normal stomach mucosa
22. Some 5′ flanking region of the pS2 gene contains a complex enhancer sequence responsive to oestrogens, EGF, a tumour promoter (TPA), the c‐fos oncoprotein, and the c‐jun oncoprotein
23. Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF‐7
24. Estrogen responsive element of the human pS2 gene is an imperfectly palindromic sequence
25. Prediction of relapse in breast cancer patients
26. Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERB‐B2
27. Estrogen induced pS2 protein is similar to PSP and the kringle domain
28. A new repetitive protein from Xenopus laevis is highly homologous to pancreatic spasmolytic polypeptide
29. A surprising sequence homology
30. Pancreatic spasmylotic polypeptide IV. Pharmacology of a new porcine pancreatic polypeptide—spasmolytic and gastric acid inhibitory effects
31. Pancreatic spasmolytic polypeptide (PSP) I. Preparation and initial chemical characterisation of a new polypeptide from porcine pancreas
32. Receptor binding of pancreatic spasmolytic polypeptide (PSP) in rat intestinal mucosal membranes inhibits adenylate cyclase activity
33. Pancreatic spasmolytic polypeptide (PSP) II. Determination of PSP in porcine tissues and plasma pancreatic juice
34. Receptor binding of pancreatic spasmolytic polypeptide PSP in intestinal mucosal cells and membranes
35. Growth stimulating effects of pancreatic spasmolytic polypeptide in cultured colon and breast tumour cells
36. Structure primaire de la protein humaine pS2
37. Production of a mouse antibody reacting with a human nuclear antigen associated with proliferation
38. Proliferating cell nuclear antigen (PCNA) immunorealisation in paraffin sections. An index of cell proliferation with evidence of deregulated expression in some neoplasms