A hinge region mutation in C1-inhibitor (Ala436 ⇒ Thr) results in nonsubstrate-like behavior and in polymerization of the molecule

Journal of Biological Chemistry

Volumn 268, Issue 24, 1993, Pages 18088-18094

  Aulak, Kulwant S ^a   Eldering, Eric ^b   Hack, C Erik ^b   Lubbers, Yvonne P T ^b   Harrison, Richard A ^c   Mast, Alan ^d   Cicardi, Marco ^e   Davis III, Alvin E ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; COMPLEMENT COMPONENT C1S INHIBITOR; THREONINE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL LINE; CHEMISTRY; DENSITY GRADIENT CENTRIFUGATION; DRUG STABILITY; ELECTRON MICROSCOPY; GEL CHROMATOGRAPHY; GENETIC TRANSFECTION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MOLECULAR CLONING; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DENATURATION; THERMODYNAMICS;

ALANINE; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CENTRIFUGATION, DENSITY GRADIENT; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; COMPLEMENT 1 INACTIVATORS; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMAN; MICROSCOPY, ELECTRON; POINT MUTATION; PROTEIN DENATURATION; SUPPORT, U.S. GOV'T, P.H.S.; THERMODYNAMICS; THREONINE; TRANSFECTION;

EID: 0027923966     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)