Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies

European Journal of Pharmacology: Molecular Pharmacology

Volumn 244, Issue 3, 1993, Pages 293-301

  Suman Chauhan, Nirmala ^a   Webdale, Louise ^a   Hill, David R ^a   Woodruff, Geoffrey N ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Anticonvulsants; Baclofen; GABA ( aminobutyric acid); GABAA receptors; GABAB receptors; Gabapentin; Glycine; NMDA (N methyl D aspartate); Polyamines

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ACETIC ACID DERIVATIVE; AMINO ACID; ANTICONVULSIVE AGENT; BACLOFEN; DRUG DERIVATIVE; GABAPENTIN; GLYCINE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER RECEPTOR; RECEPTORS, GABA A; RECEPTORS, N METHYL D ASPARTATE; SPERMIDINE; SPERMINE; 4 AMINO 3 HYDROXYBUTYRIC ACID; 4 AMINO 3 PHENYLBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; AGMATINE; ARCAINE; CARBAMAZEPINE; DIAZEPAM; EFLORNITHINE; ETHOSUXIMIDE; GABAERGIC RECEPTOR AFFECTING AGENT; IFENPRODIL; N1 ACETYLSPERMIDINE; N1 ACETYLSPERMINE; N8 ACETYLSPERMIDINE; PENTOBARBITAL; PHENOBARBITAL; PHENYTOIN; POLYAMINE; PUTRESCINE; RADIOLIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID;

ANIMAL; ARTICLE; BINDING SITE; BRAIN CORTEX; CELL MEMBRANE; DRUG EFFECT; METABOLISM; PH; RAT; AMINO ACID TRANSPORT; ANIMAL TISSUE; BINDING COMPETITION; BINDING KINETICS; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG SPECIFICITY; LIVER; LUNG; NONHUMAN; PANCREAS; PRIORITY JOURNAL; SPLEEN;

ACETIC ACIDS; AMINO ACIDS; ANIMAL; ANTICONVULSANTS; BACLOFEN; BINDING SITES; CELL MEMBRANE; CEREBRAL CORTEX; GAMMA-AMINOBUTYRIC ACID; HYDROGEN-ION CONCENTRATION; RATS; RECEPTORS, GABA-A; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NEUROTRANSMITTER; SPERMIDINE; SPERMINE;

EID: 0027916864     PISSN: 09224106     EISSN: None     Source Type: Journal    
DOI: 10.1016/0922-4106(93)90155-3     Document Type: Article

References (26)

1. 4-amino-3-alkyl-butanoic acids as substrates for γ-aminobutyric acid aminotransferase
2. Preclinical characterization of the anticonvulsant gabapentin
3. Gabapentin
4. B receptor binding sites on rat whole brain synaptic membranes
5. Gabapentin
6. Gabapentin as an antiepileptic in man
7. Preclinical pharmacology of gabapentin
8. Taking apart NMDA receptors
9. Gabapentin: action on hippocampal slices of the rat and effects in human epileptics
10. 3H]gabapentin to a novel site in rat brain: autoradiographic studies
11. Glycine potentiates the NMDA response in cultured mouse brain neurones
12. 2+ of NMDA responses in spinal cord neurons
13. GABA and other amino acids
14. The anticonvulsant action of gabapentin involves the glycine/NMDA receptor
15. The anticonvulsant action of gabapentin involves the glycine/NMDA receptor
16. 3H]MK-801 binding to the N-methyl-D-aspartate receptor ion channel complex by L-glutamate, glycine and polyamines
17. Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor
18. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines
19. 3H]-(-[thienyl]cyclohexyl)piperidine binding by arcaine: evidence for a shared spermidine-magnesium binding site
20. 3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase
21. Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor channel complex
22. Allosteric Modulation of the NMDA-Receptor Complex
23. In vitro and in vivo effects of the anticonvulsant gabapentin
24. Gabapentin in the treatment of drug-resistant epileptic patients
25. Modulation of the NMDA receptor by polyamines
26. 3H]MK-801 binding to the NMDA receptor in rat brain