Effect of ischaemia and reperfusion on the extra- and intracellular distribution of glutamate, glutamine, aspartate and GABA in the rat hippocampus, with a note on the effect of the sodium channel blocker BW1003C87

Experimental Brain Research

Volumn 96, Issue 3, 1993, Pages 365-376

  Torp, R ^a   Arvin, B ^b   Le Peillet, E ^b   Chapman, A G ^b   Ottersen, O P ^a   Meldrum, B S ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Amino acid neurotransmitters; Glutamate; Hippocampal damage; Immunocytochemistry; Ischaemia; Microdialysis; Rat

Indexed keywords

2,4 DIAMINO 5 (2,3,5 TRICHLOROPHENYL)PYRIMIDINE; 4 AMINOBUTYRIC ACID; AMINO ACID; ANTIBODY; ANTISERUM; ASPARTIC ACID; GLUTAMIC ACID; GLUTAMINE; GLUTARALDEHYDE; GOLD; NEUROTRANSMITTER; PROTEIN; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CELLULAR DISTRIBUTION; COMMON CAROTID ARTERY; CONCENTRATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; FOREBRAIN; GLIA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; ISCHEMIA; LEFT HEMISPHERE; MALE; MICRODIALYSIS; NONHUMAN; OCCLUSION; PARTICLE SIZE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; REPERFUSION; VERTEBRAL ARTERY;

ANIMAL; ASPARTIC ACID; CALCIUM CHANNEL BLOCKERS; EXTRACELLULAR SPACE; GAMMA-AMINOBUTYRIC ACID; GLUTAMATES; GLUTAMIC ACID; GLUTAMINE; HIPPOCAMPUS; INTRACELLULAR FLUID; ISCHEMIC ATTACK, TRANSIENT; MALE; MICRODIALYSIS; MICROSCOPY, IMMUNOELECTRON; NEURONS; PYRAMIDAL CELLS; PYRIMIDINES; RATS; RATS, WISTAR; REPERFUSION; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

EID: 0027842804     PISSN: 00144819     EISSN: 14321106     Source Type: Journal    
DOI: 10.1007/BF00234106     Document Type: Article

References (54)

1. The excitotoxin hypothesis in relation to cerebral ischemia
2. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
3. Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3
4. Morforel, a computer program for two-dimensional analysis of micrographs of biological specimens, with emphasis on immunogold preparations
5. Distribution of glutamate-like immunoreactivity in excitatory hippocampal pathways: a semiquantitative electron microscopic study in rats
6. Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate
7. Cerebral hypoxia: some new approaches and unanswered questions
8. Glutamine synthetase
9. In vivo brain dialysis of neurotransmitters
10. Effect of ischaemia on the in vivo release of striatal dopamine, glutamate and aminobutyric acid studied by intracerebral microdialysis
11. Ischemia induces release of glutamate in regions spared from histopathologic damage in the rat
12. Hypoxia and vascular disorders
13. Ischemia-induced shift of inhibitory and excitatory amino acids from intrato extracellular compartments
14. An electron microscopic, immunogold analysis of glutamate and glutamine in terminals of rat spinocerebellar fibers
15. Selective dendrite damage in hippocampal CA stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat
16. Ischemic CA1 pyramidal cell loss is prevented by pre-ischemic colchicine destruction of dentate gyrus granule cells
17. Ca2+-dependent and Ca2+-independent glutamate release, energy status and cytosolic free Ca2+-concentration in isolated nerve terminals following metabolic inhibition: possible relevance to hypoglycaemia and anoxia
18. Glutaminases
19. An antiserum against glutamine
20. Concomitant increases in the extracellular concentrations of excitatory and inhibitatory amino acids in the rat hippocampus following transient forebrain ischemia
21. Immunocytochemical localization of taurine: methodological aspects
22. Ischemic neurons injury in the rat hippocampus following transient forebrain ischemia: evaluation using in vivo microdialysis
23. Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission
24. Reduction of glutamate release and protection against ischaemic brain damage by BW 1003C87
25. Visualization of hypoxia-induced glutamate release in gerbil hippocampal slice
26. Selective vulnerability of hippocampal CA1 neurons cannot be explained in terms of an increase in glutamate concentration during ischemia in the gerbil: brain microdialysis study
27. Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia
28. Release of glutamate, aspartate, and γ-aminobutyric acid from isolated nerve terminals
29. The release and uptake of excitatory amino acids
30. Postembedding lightand electronmicroscopic immunocytochemistry of amino acids. Description of a new model system allowing identical conditions for specificity testing and tissue processing
31. Quantitative electron microscopic immunocytochemistry of amino acids
32. Glutamateand GABAcontaining neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique
33. A quantitative electron microscopic immunocytochemical study of the distribution and synaptic handling of glutamate in rat hippocampus
34. Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum
35. Postmortem changes of amino componds in human and rat brain
36. Astrocytes in cerebral ischemia
37. Cloning and expression of a rat brain l-glutamate transporter
38. Deafferentation of the hippocampus protects CA1 pyramidal neurons against ischemic injury
39. A new model of bilateral hemispheric ischemia in the unanaesthetized rat
40. Occurrence of a large Ca2+independent release of glutamate during anoxia in isolated nerve terminals (synaptosomes)
41. Potassiumstimulated release of taurine from cultured cerebellar granule neurons is associated with cell swelling
42. Selective vulnerability of the hippocampus in brain ischemia
43. 2.3-Dihydroxy-6-nitro-7-sulfamoyl-benzo-(F) quinoxaline: a neuroprotectant for cerebral ischemia
44. Blockade of N-methyl- d-aspartate receptors may protect against ischemic damage in the brain
45. Structure, expression, and functional analysis of a Na+-dependent glutamate/aspartate transporter from rat brain
46. First visualization of glutamate and GABA in neurons by immunocytochemistry
47. Cellular and subcellular redistribution of glutamatelike, glutamine-like and taurine-like immunoreactivity during forebrain ischemia: a semiquantitative electron microscopic study in rat hippocampus
48. Regional distribution and extracellular levels of amino acids in rat central nervous system
49. Measurement of neurotransmitter release by intracranial dialysis
50. Simultaneous demonstration of multiple antigens by indirect immunofluorescence or immunogold staining. Novel light and electron microscopical double and triple staining method employing primary antibodies from the same species
51. Evidence for amelioration of ischemie neuronal damage in hippocampal formation by lesions of the perforant path
52. Postmortem GABA increase in discrete regions of the brain involvement of GAD and GABA-T activity