Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): Interaction with reductants in model systems, k562 leukemic cell and nuclear homogenates

Free Radical Research

Volumn 19, Issue 6, 1993, Pages 371-386

  Stoyanovsky, D ^a   Yalowich, J ^b,c   Gantchev, T ^c   Kagan, V ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Ascorbate; Dihydrolipoic acid; Etoposide; Glutathione; K562 leukemic cells; Phenoxyl radical; Tyrosinase

Indexed keywords

ANTINEOPLASTIC AGENT; ASCORBIC ACID; DIHYDROLIPOATE; DNA TOPOISOMERASE; DRUG METABOLITE; ETOPOSIDE; FREE RADICAL; GLUTATHIONE; MONOPHENOL MONOOXYGENASE; PHENOL DERIVATIVE; REDUCING AGENT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL FREE SYSTEM; CELL STRAIN K 562; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND BREAKAGE; DRUG ACTIVATION; DRUG BINDING; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG METABOLISM; DRUG OXIDATION; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTRACELLULAR FLUID; LEUKEMIA CELL; METABOLIC ACTIVATION; REDUCTION; STRUCTURE ACTIVITY RELATION;

ASCORBIC ACID; CELL NUCLEUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEFEROXAMINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ETOPOSIDE; FREE RADICALS; GLUTATHIONE; HUMAN; LEUKEMIA; MONOPHENOL MONOOXYGENASE; OXIDATION-REDUCTION; PHENOLS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THIOCTIC ACID; TUMOR CELLS, CULTURED;

EID: 0027787910     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.3109/10715769309056527     Document Type: Article

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