PKCγ mutant mice exhibit mild deficits in spatial and contextual learning

Cell

Volumn 75, Issue 7, 1993, Pages 1263-1271

  Abeliovich, Asa ^a   Paylor, Richard ^b   Chen, Chong ^a   Kim, Jeansok J ^c   Wehner, Jeanne M ^b   Tonegawa, Susumu ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOENZYME; PROTEIN KINASE C;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONDITIONING; FEAR; FEMALE; HIPPOCAMPUS; LEARNING DISORDER; LONG TERM POTENTIATION; MALE; MAZE TEST; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; SPATIAL ORIENTATION; TETANUS;

ANIMALIA; MAMMALIA;

EID: 0027787664     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90614-V     Document Type: Article

References (42)

1. Modified hippocampal long-term potentiation in PKCγ-mutant mice
2. Classical conditioning induces long-term translocation of protein kinase C in rabbit hippocampal CA1 cells
3. Learning-induced activation of protein kinase C: a molecular memory trace
4. Computational implications of NMDA receptor channels
5. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthesized rabbit following stimulation of the perforant path
6. Long-lasting potentiation of synaptic transmission in the dentate area of the unanaesthesized rabbit following stimulation of the perforant path
7. Excitatory amino acids and synaptic plasticity
8. Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade
9. Memory representation in the hippocampus: functional domain and functional organization
10. The Hippocampus: What does it do?
11. Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice
12. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
13. Postnatal development of a brain-specific subspecies of protein kinase C in rat
14. The hippocampus and contextual retrieval of information from memory: a theory
15. On the role of the hippocampus in learning and memory in rat
16. Modality-specific retrograde amnesia of fear
17. N-methyl-D-aspartate antagonist APV blocks acquisition but not expression of fear conditioning
18. Persistent protein kinase activity underlying long-term potentiation
19. Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP
20. Spatial localization does not require the presence of local cues
21. Place navigation impaired in rats with hippocampal lesions
22. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist AP5
23. Hippocampal synaptic plasticity and N-methyl-D-aspartate channels: a role in information storage?
24. Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus
25. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
26. A role for protein kinase C in associative learning
27. Discrimination learning alters the distribution of protein kinase C in hippocampus of young rats
28. Brief exposure to an enriched environment improves performance in the Morris water task and increases hippocampal cytosolic protein kinase C activity in young rats
29. Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: a hippocampal-disfunction hypothesis
30. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning
31. Learning-related synaptic plasticity: LTP and LTD
32. Deficient hippocampal long-term potentiation in α-calcium-calmodulin kinase II-mutant mice
33. Impaired spatial learning in α-calcium-calmodulin kinase II-mutant mice
34. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans
35. Configural association theory: the role of the hippocampal formation in learning, memory, and amnesia
36. Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat
37. Changes in PKCγ immunoreactivity in mouse hippocampus induced by spatial discrimination learning
38. Hippocampal protein kinase C activity is reduced in poor spatial learners