FR901459, a novel immunosuppressant isolated fromstachybotrys chartarum no. 19392 taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities

Journal of Antibiotics

Volumn 46, Issue 12, 1993, Pages 1788-1798

  Sakamoto, Kazutoshi ^a   Tsujii, Eisaku ^a   Miyauchi, Michiyo ^a   Nakanishi, Tomoko ^a   Yamashita, Michio ^a   Shigematsu, Nobuharu ^a   Tada, Toshiharu ^a   Izumi, Shizue ^a   Okuhara, Masakuni ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYCLOSPORIN A; FR 901459; IMMUNOSUPPRESSIVE AGENT; LEUCINE; UNCLASSIFIED DRUG; VALINE; FUNGAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; FEMALE; FERMENTATION; GRAFT SURVIVAL; HYPHOMYCETES; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SKIN ALLOGRAFT; TAXONOMY; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOUSE STRAIN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STACHYBOTRYS;

AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY, PHYSICAL; COMPARATIVE STUDY; CYCLOSPORINE; FEMALE; FERMENTATION; FUNGAL PROTEINS; IMMUNOSUPPRESSIVE AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; STACHYBOTRYS;

EID: 0027787433     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.46.1788     Document Type: Article

References (24)

1. Nussenblatt, R. B.; A. H. Rook, W. B. Wacker, A. G. Paleatine, I. Scher & I. Gery: Treatment of intraocular inflammatory diseases with cyclosporin A. Lancet 1983 II: 235-238, 1983
2. Kawashima, H.; Y. Fujino & M. Mochizuki: Effects of a new immunosuppressive agent, FK506, on experimental autoimmune uveoretinitis in rats. Invest. Ophthalmol. 29: 1265-1271, 1988
3. Stiller, C. R.; J. Dupre, M. Gent, M. R. Jenner, P. A. Keown, A. Laupacis, R. Martell, N. W. Rodger, B. V. Graffenried & B. M. J. Wolfe: Effect of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 223: 1362-1367, 1984
4. Murase, N.; I. Lieberman, M. A. Nalesnik, D. H. Mintz, S. Todo, A. L. Drash & T. E. Starzl: Effect of FK506 on spontaneous diabetes in BB rats. Diabetes 39: 1584-1586, 1990
5. Weinblatt, M. E.; J. S. Coblyn, P. A. Fraser, R. J. Anderson, J. Spragg, D. E. Trentham & K. F. Austen: Cyclosporin A treatment of refractory rheumatoid arthritis. Arthritis Rheum. 30: 11-17, 1987
6. Inamura, N.; M. Hashimoto, K. Nakahara, H. Aoki, I. Yamaguchi & M. Kohsaka: Immunosuppressive effect of FK506 on collagen-induced arthritis in rats. Clin. Immunol. Immunother. 46: 82-90, 1988
7. Izumi, S.; H. Ueda, M. Okuhara, H. Aoki & Y. Yamamura: Effect of Nocardia rubra cell wall skeleton on murine interferon production in vitro. Cancer Res. 46: 1960-1965, 1986
8. Inamura, N.; K. Nakahara, T. Kino, T. Goto, H. Aoki, I. Yamaguchi, M. Kohsaka & T. Ochiai: Prolongation of skin allograft survival in rats by a novel immunosuppressive agent, FK506. Transplantation 45: 206-209, 1988
9. Kornerup, A. & J. H. Wanscher: Methuen Handbook of Colour, Methuen, 1978
10. Jong, S. C. & E. E. Davis: Contribution to the knowledge of Stachybotrys and Memnoniella in culture. Mycotaxon 3: 409-485, 1976
11. Elliott, J. F.; Y. Lin, S. B. Mizel, R. C. Bleackley, D. G. Harnish & V. Paetkau: Induction of interleukin 2 messenger RNA inhibited by cyclosporin A. Science 226: 1439-1441, 1984
12. Granelli-Piperno, A.; K. Inaba & R. M. Steinman: Stimulation of lymphokine release from T lymphoblasts. Requirement for mRNA synthesis and inhibition by cyclosporin A. J. Exp. Med. 160: 1792-1802, 1984
13. von Wartburg, A. & R. Traber: Chemistry of the natural cyclosporin metabolites. In Progress in Allergy, vol. 38. Ciclosporin. Ed., J. F. Borel, pp. 28-45, Karger, Basel, 1986
14. Dreyfuss, M.; E. Harri, H. Hofmann, H. Kobel, W. Pache & H. Tscherter: Cyclosporin A and C. Eur. J. Appl. Microbiol. 3: 125-133, 1976
15. Dreyfuss, M. M.: Neue Erkenntnisse aus einem pharmakologischen Pilz-Screening. Sydowia 39: 22-36, 1986
16. Borel, J. F.; C. Feurer, H. U. Gubler & H. Stahelin: Biological effects of cyclosporin A: A new antilymphocytic agent. Agents Actions 6: 468-475, 1976
17. Sawai, K.; T. Okuno, Y. Terada, Y. Harada, K. Sawamura, H. Sasaki & S. Takao: Isolation and properties of two antifungal substances from Fusarium solani. Agric. Biol. Chem. 45: 1223-1228, 1981
18. Aarnio, T. H. & S. N. Agathos: Production of extracellular enzymes and cyclosporin by Tolypocladium inflatum and morphologically related fungi. Biotechnology Letters 11: 759-764, 1989
19. Nakajima, H.; T. Hamasaki, K. Nishimura, T. Kondo, Y. Kimura, S. Udagawa & S. Sato: Isolation of 2-acetylamino-3-hydroxy-4-methyloct-6-enoic acid, a derivative of the “C9-amino acid” residue of cyclosporins, produced by the fungus Neocosmospora vasinfecta E. F. Smith. Agric. Biol. Chem. 52: 1621-1623, 1988
20. Takahashi, N.; T. Hayano & M. Suzuki: Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin. Nature 337: 473-475, 1989
21. Fischer, G.; B. Wittmann-Liebold, K. Lang, T. Kiefhaber & F. X. Schmid: Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature 337: 476-478, 1989
22. Handschumacher, R. E.; M. W. Harding, J. Rice & R. J. Drugge: Cyclophilin: A specific cytosolic binding protein for cyclosporin A. Science 226: 544-546, 1984
23. Soo, Y. K. & C. Dalvit: Conformation of cyclosporin A in polar solvents. Int. J. Peptide Protein Res. 40: 380-382, 1992
24. Kessler, H.; M. Gehrke, J. Lautz, M. Kock, D. Seebach & A. Thaler: Complexation and medium effects on the conformation of cyclosporin A studied by NMR spectroscopy and molecular dynamics calculations. Biochem. Pharmacol. 40: 169-173, 1990