The Use of Nicotinamide in the Prevention of Type 1 Diabetes

Annals of the New York Academy of Sciences

Volumn 696, Issue 1, 1993, Pages 333-341

  ELLIOTT, R B ^a   PILCHER, C C ^a   STEWART, A ^a   FERGUSSON, D ^b   McGREGOR, M A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; NICOTINAMIDE; PANCREAS ISLET CELL ANTIBODY; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CHILD; CONFERENCE PAPER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PANCREAS ISLET; PANCREATITIS; RAT;

ANIMALIA;

EID: 0027771746     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1993.tb17169.x     Document Type: Article

References (17)

1. ICA only develop in early childhood
2. Evidence for a long prediabetic period in type 1 (insulin dependent) diabetes mellitus
3. Diagnosis of pre‐type 1 diabetes
4. Preventive and therapeutic effects of large‐dose nicotinamide injections on diabetes associated with insulitis
5. Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are beta‐cell specific
6. Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide
7. Affinity‐purified human interleukin 1 is cytotoxic to isolated islets of Langerhans
8. Nicotinamide partially reverses the interleukin‐1β inhibition of glucose‐induced insulin release in pancreatic islets
9. A sensitive and reproducible method for the assay of human islet cell antibodies
10. The pattern of basal and stimulated insulin responses to intravenous glucose in first degree relatives of type 1 (insulin dependent) diabetic children and unrelated adults aged 5–50 years
11. Prevention or delay of type 1 (insulin dependent) diabetes mellitus in children using nicotinamide
12. A prospective study of the development of diabetes in relatives of patients with insulin‐dependent diabetes
13. Quantification of islet cell antibodies and prediction of insulin‐dependent diabetes
14. A trial of nicotinamide in newly diagnosed patients with type 1 (insulin‐dependent) diabetes mellitus
15. Mechanisms of nicotinamide and thymidine protection from alloxan and streptozocin toxicity
16. Molecular mechanism of degeneration, oncogenesis and regeneration of pancreatic B‐cells of islets of Langerhans
17. Induction of rat pancreatic beta‐cell tumors by the combined administration of streptozotocin or alloxan and poly (adenosine diphosphate ribose) synthetase inhibitors