Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization

Molecular and Cellular Biochemistry

Volumn 127-128, Issue 1, 1993, Pages 229-237

  Stull, James T ^a,b   Tansey, Malú G ^a,b   Tang, Da Chun ^a,b   Word, R Ann ^a,b   Kamm, Kristine E ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

calcium; contraction; myosin; protein phosphorylation; second messengers; smooth muscle

Indexed keywords

CALCIUM; MYOSIN LIGHT CHAIN; PROTEIN KINASE;

ANIMAL TISSUE; CALCIUM TRANSPORT; CELL SHAPE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; NONHUMAN; REVIEW; SECOND MESSENGER; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; THROMBOCYTE AGGREGATION;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; BLOOD PLATELETS; CALCIUM; CALMODULIN; HOMEOSTASIS; HUMAN; MOLECULAR SEQUENCE DATA; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOSIN-LIGHT-CHAIN KINASE; PHOSPHORYLATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027770851     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/BF01076774     Document Type: Article

References (35)

1. Ca2+, crossbridge phosphorylation, and contraction
2. Vascular smooth muscle contractile elements: cellular regulation
3. Regulation of contractile activity
4. Myosins of nonmuscle cells
5. Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. Phosphorylation sites and effects of phosphorylation
6. Sequence of the sites phosphorylated by protein kinase C in the smooth muscle myosin light chain
7. Sites phosphorylated in myosin light chain in contracting smooth muscle
8. Phosphorylation of smooth muscle myosin heavy and light chains: Effects of phorbol dibutyrate and agonists
9. Protein kinase C activation and myosin light chain phosphorylation in32P-labeled arterial smooth muscle
10. Substance P contracts bovine tracheal smooth muscle via activation of myosin light chain kinase
11. In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C
12. Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells
13. Phorbol esterinduced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains
14. The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3′:5′ cAMP-dependent protein kinase
15. The role of myosin light chain kinase phosphorylation in β-adrenergic relaxation of tracheal smooth muscle
16. Increased phosphorylation of myosin light chain kinase after an increase in cyclic AMP in intact smooth muscle
17. Phosphorylation-dephosphorylation of enzymes
18. Calmodulin binding domains: characterization of a phosphorylation and clamodulin binding site from myosin light chain kinase
19. Smooth muscle myosin light chain kinase. Amino acid sequence at the site phosphorylated by adenosine cyclic 3′,5′-phosphate-dependent protein kinase whether or not calmodulin is bound
20. Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP-dependent protein kinase and by cyclic GMP-dependent protein kinase
21. Phosphorylation of smooth muscle heavy meromyosin by calcium-activated, phospholipid-dependent protein kinase. The effect on actin-activated MgATPase activity
22. Phosphorylation of smooth muscle myosin light chain kinase by Ca2+/calmodulin-dependent protein kinase-II. Comparative study of the phosphorylation sites
23. Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase
24. Site-specific dephosphorylation of smooth muscle myosin light chain kinase by protein phosphatases 1 and 2A
25. Comparison of the properties of the protein phosphatases from avian and mammalian smooth muscles: purification and characterization of rabbit uterine smooth muscle phosphatases
26. Myosin light chain kinase phosphorylation in tracheal smooth muscle
27. Phosphorylation of myosin light kinase by the multifictional calmodulin-dependent protein kinase II in smooth muscle cells
28. Phosphorylation of myosin light chain kinase by the multi-functional calmodulin-dependent protein kinase affects the calcium sensitivity of myosin light chain phosphorylation
29. Regulation of the Ca2+ dependence of smooth muscle contraction
30. Cytoplasmic Ca2+, is a primary determinant for myosin phosphorylation in smooth muscle cells
31. Increases in [Ca2+] myosin light chain (LC) phosphorylation, and force during the initiation of smooth muscle contraction
32. Calcium pump of the plasma membrane
33. Catalytic properties of inositol trisphosphate kinase: activation by Ca2+ and calmodulin
34. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells
35. Molecular characterization of a mammalian smooth muscle myosin light chain kinase