Reperfusion in acute myocardial infarction: Effect of timing and modulating factors in experimental models

The American Journal of Cardiology

Volumn 72, Issue 19, 1993, Pages

  Reimer, Keith A ^a   Heide, Richard S Vander ^a   Richard, Vincent J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE HEART INFARCTION; ANIMAL MODEL; CELL DEATH; CONFERENCE PAPER; CORONARY ARTERY COLLATERAL CIRCULATION; HEART INFARCTION SIZE; HEART MUSCLE METABOLISM; HEART MUSCLE REPERFUSION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMAL; DISEASE MODELS, ANIMAL; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0027769607     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/0002-9149(93)90102-I     Document Type: Article

References (59)

1. Myocardial infarction in the conscious dog: three-dimensional mapping of infarct, collateral flow and region at risk
2. The “wavefront phenomenon” of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow
3. Animal models for protecting ischemic myocardium (AMPIM): results of the NHLBI cooperative study. Comparison of the unconscious and conscious dog models
4. Transmural cellular damage and blood flow distribution in early ischemia in pig hearts
5. Regional myocardial blood flow and necrosis in primates following coronary occlusion
6. Arterial anastomoses in the coronary circulation I Anatomical features in normal and diseased hearts demonstrated by sterioarteriography
7. Ischemic tissue injury
8. Transmural distribution of myocardial blood flow during systole in the awake dog
9. Opposite transmural gradients of coronary resistance and extravascular pressure in the working dog's heart
10. Effect of perfusion pressure distal to a coronary stenosis on transmural myocardial blood flow
11. The distribution of myocardial flow I Effects of experimental coronary occlusion
12. Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites and ultrastructure
13. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog
14. The wavefront phenomenon of ischemic cell death. I. Myocardial infarct size vs. duration of coronary occlusion in dogs
15. Effects of coronary artery reperfusion on myocardial infarct size and survival in conscious dogs
16. Movement of necrotic wavefront after coronary artery occlusion in rabbit
17. Quantitative effect of early coronary artery reperfusion in baboons: extent of salvage of the perfusion bed of an occluded artery
18. Temporal and spatial development of infarcts in porcine hearts
19. Studies of experimental coronary artery reperfusion: effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage
20. Experimental coronary artery occlusion. II. Spatial and temporal evolution of infarcts in the dog heart
21. Myocardial infarct size and location in relation to the coronary vascular bed at risk in man
22. Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog
23. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium
24. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode
25. Role of glycolytic products in damage to ischemic myocardium: dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts
26. Effect of hypothermia on changes in high-energy phosphate production and utilization in total ischemia
27. Verapamil in two reperfusion models of myocardial infarction. Temporary protection of severely ischemic myocardium without limitation of ultimate infarct size
28. Myocardial ischemia, hypoxia, and infarction
29. An experimental and theoretical analysis of tissue pressure
30. Why the endocardium?
31. Evidence that ischemic cell death begins in the subendocardium independent of variations in collateral flow or wall tension
32. Effects of calcium antagonists in infarcting myocardium
33. Fundamental mechanisms of action of calcium antagonists in myocardial ischemia
34. 1 adenosine receptors in rabbit heart
35. Ischemic preconditioning protects against infarction in rat heart
36. Ischemic preconditioning reduces infarct size in swine myocardium
37. Ischaemic preconditioning limits infarct size in the rat heart
38. Adaptation to ischemia during PTCA: Clinical, hemodynamic and metabolic features
39. Preconditioning does not attenuate myocardial stunning
40. Preconditioning: definitions, proposed mechanisms and implications for myocardial protection in ischaemia and reperfusion
41. The role of neutrophils and free radicals in the ischemic-reperfused heart: why the confusion and controversy?
42. Demonstration of free radical generation in “stunned” myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone
43. Evaluation of free radical injury in myocardium
44. Mechanism of myocardial stunning
45. Coronary angioplasty as primary therapy for acute myocardial infarction 6 to 48 hours after symptom onset: report of an initial experience
46. Randomised trial of intravenous streptokinase oral aspirin both or neither among 17187 cases of suspected acute myocardial infarction ISIS-2
47. Myocardial reperfusion: is it ever too late?
48. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications
49. Effects of late reperfusion after myocardial necrosis is complete
50. Limitation of myocardial expansion by reperfusion independent of myocardial salvage
51. Left ventricular topographic alternations in the completely healed rat infarct caused by early and late coronary artery reperfusion
52. Myocardial neutrpphil accumulation during reperfusion after reversible and irreversible ischemic injury
53. The heart
54. Cardiac rupture, mortality and the timing of thrombotytic therapy: a meta-analysis
55. Effects of reperfusion after coronary artery occlusion on post-infarction scar tissue
56. The xanthine oxidase inhibitor oxypurinol does not limit infarct size in a canine model of 40 minutes of ischemia with reperfusion
57. Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs
58. Therapy to reduce free radicals during early reperfusion does not limit the size of myocardial infarcts caused by 90 minutes of ischemia in dogs
59. Evidence against the “early protection-delayed death” hypothesis of Superoxide dismutase therapy in experimental myocardial infarction. Polyethylene glycol-superoxide dismutase plus catalase does not limit myocardial infarct size in dogs