Epibatidine is a nicotinic analgesic

European Journal of Pharmacology

Volumn 250, Issue 3, 1993, Pages

  Changgeng Qian, ^a   Tongchuan Li, ^a   Shen, T Y ^b   Libertine Garahan, Lyn ^a   Eckman, Joseph ^a   Biftu, Tesfaye ^a   Ip, Stephen ^a  

^a CytoMed Inc   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Analgesia; Epibatidine; Nicotinic receptor

Indexed keywords

ALKALOID; ANALGESIC AGENT; ATROPINE; CYTISINE; EPIBATIDINE; HEXAMETHONIUM; MECAMYLAMINE; NALOXONE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; PIRENZEPINE; RADIOISOTOPE; YOHIMBINE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BRAIN; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG POTENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TAIL FLICK TEST;

ALKALOIDS; ANALGESICS; ANIMAL; BICYCLO COMPOUNDS; BINDING, COMPETITIVE; BRAIN; COMPARATIVE STUDY; DRUG INTERACTIONS; MECAMYLAMINE; MICE; NICOTINE; PYRIDINES; RATS; RECEPTORS, NICOTINIC;

EID: 0027767522     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(93)90043-H     Document Type: Article

References (8)

1. Frog venom cocktail yields a one-handed painkiller
2. Total synthesis of epibatidine
3. The synthesis of (+)- and (−)-epibatidine
4. 3H]cytisine binding to human brain membrane preparation
5. A versatile total synthesis of epibatidine and analogs
6. Beneficial effects of nicotine
7. Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog
8. Nicotine-induced antinociception in rats and mice: correlation with nicotine brain levels