Treatment of social phobia with clonazepam and placebo

Journal of Clinical Psychopharmacology

Volumn 13, Issue 6, 1993, Pages 423-428

  Davidson, Jonathan R T ^a   Potfs, Nicholas ^a   Richichi, Emilia ^a   Krishnan, Ranga ^a   Ford, Stephen M ^a   Smith, Rebecca ^a   Wilson, William H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONAZEPAM; PLACEBO;

ANXIETY; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERANCE; HUMAN; MAJOR CLINICAL STUDY; PERFORMANCE; PHOBIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOCIAL PSYCHIATRY; VERTIGO; VISUAL IMPAIRMENT;

ADULT; ANXIETY; CLONAZEPAM; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; PHOBIC DISORDERS; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES;

EID: 0027764363     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/00004714-199312000-00008     Document Type: Article

References (37)

1. Liebowitz MR, Gorman JM, Fyer AJ, Campeas R, Lavin AR, Sandberg D, Hollander E, Papp L, Goetz D: Pharmacotherapy of social phobia: an interim response of a placebo-controlled comparison of phenelzine and atenolol. J Clin Psychiatry 1988;49:252–7.
2. Liebowitz MR, Schneier F, Campeas R, Hollander E, Hatterer J, Fyer A, Gorman JM, Papp L, Davies S, Gully R, Klein DF: Phenelzine vs atenolol in social phobia: a placebo-controlled comparison. Arch Gen Psychiatry 1992;49:290–300.
3. Versiani M, Nardi AE, Mundim FD, Alves AB, Liebowitz MR, Amrein R: Pharmacotherapy of social phobia. A controlled study of moclobemide and phenelzine. Br J Psychiatry 1992;161:353–60.
4. van Vliet IM, den Boer JA, Westerberg GM: Psychopharmacological treatment of social phobia: clinical and biochemical effects of brofaromine, a selective MAO-A inhibitor. Eur J Neuropsychopharmacol 1991;2:21–9.
5. Gelernter CS, Uhde TW, Cimbolic P, Amkoff DB, Vittone BJ, Tancer ME, Bartko JJ: Cognitive-behavioral and pharmacological treatments of social phobia. A controlled study. Arch Gen Psychiatry 1991;48:938–45.
6. Versiani M, Mundim FD, Nardi AE, Liebowitz MR: Tranylcypromine in social phobia. J Clin Psychopharmacol 1988;8:279–82.
7. Liebowitz MR, Fyer AJ, Gorman JM, Campeas R, Levin A: Phenelzine in social phobia. J Clin Psychopharmacol 1986;6:93–8.
8. Schneier F, Chin SJ, Hollander E, Liebowitz MR: Fluoxetine in social phobia. J Clin Psychopharmacol 1992;12:62–3.
9. Gorman JM, Liebowitz MR, Fyer AJ, Catnpeas R, Klein DF: Treatment of social phobia with atenolol. J Clin Psychopharmacol 1985;5:298–301.
10. Munjack DJ, Baltazar PL, Bohn PB, Cabe DD, Appelson AA: Clonazepam in the treatment of social phobia: a pilot study. J Clin Psychiatry 1990;51(suppl 5)35–40.
11. Ontiveros A, Fontaine R: Social phobia and clonazepam. Can J Psychiatry 1990;35:439–41.
12. Reiter SR, Pollack MH, Rosenbaum JF, Cohen LS: Clonazepam in the treatment of social phobia. J Clin Psychiatry 1990;51:470–2.
13. Reich JR, Noyes R, Yates W: Alprazolam treatment of avoidant personality traits in social phobic patients. J Clin Psychiatry 1989;50:991–5.
14. Lydiard RB, Laraia MT, Howell EF, Ballenger JC: Alprazolam in the treatment of social phobia. J Clin Psychiatry 1988;49:17–9.
15. Goldstein S: Treatment of social phobia with clonidine. Biol Psychiatry 1987;22:369–72.
16. Lydiard RB, Ballenger JC: Treatment of social phobia with bupropion. J Clin Psychopharmacol 1991;11:276.
17. Benca R, Matuzas W, Al-Sadir J: Social phobia, MVP and response to imipramine. J Clin Psychopharmacol 1986;6:50–1.
18. Davidson JRT, Ford SM, Smith RD, Potts NLS: Long term treatment of social phobia with clonazepam. J Clin Psychiatry 1991;52(suppl 11):16–20.
19. Tesar GE, Rosenbaum JF, Pollack MH, Otto MW, Sadis GS, Herman JB, Cohen LS, Spier SA: Double-blind, placebo-controlled comparison of clonazepam and alprazolam in panic disorder. J Clin Psychiatry 1991;51:69–76.
20. Clark DB, Agras WS: The assessment and treatment of performance anxiety in musicians. Am J Psychiatry 1991;148:598–605.
21. Spitzer RL, Williams JBW: Structured clinical interview for DSM-III-R. New York: Biometrics Research Unit, New York State Psychiatric Institute, 1988.
22. Guy W: ECDEU Assessment manual for psychopharmacology. Washington, DC: Department of Health, Education and Welfare, Publications #(ADM) 76–338, 1976;217–22.
23. Liebowitz MR: Social phobia. ln: Klein DF, ed. Modern Problems in Pharmacopsychiatry, Anxiety. New York: Karger, 1987:141–73.
24. Marks IM, Matthews AM: Brief standard self-rating for phobic patients. Behav Res Ther 1982;17:263–67.
25. Watson P, Friend R: Measurement of social-evaluative anxiety. J Consult Clin Psychol 1969;33:448–57.
26. Hamilton M: Development of a rating scale for primary depressive illness. Br J Soc Colin Psychol 1967;6:278–96.
27. Kelly D, Guirguis W, Frommer E, Mitchell-Heggs N, Sargant W: Treatment of phobic states with antidepressants: a retrospective study of 246 patients. Br J Psychiatry 1970;116:387–98.
28. Sheehan DV: The anxiety disease. New York, Bantam Books, 1986: 138.
29. Davidson JRT, Kudler HS, Smith RD, Mahorney SL, Lipper SL, Hammett EB, Saunders WB, Cavenar JO: Treatment of posttraumatic stress disorder with arnitriptyline and placebo. Arch Gen Psychiatry 1990;4:259–69.
30. Davidson JRT, Hughes DL, Blazer DG, George LK: Epidemiology of social phobia: findings from the Duke Epidemiological Catchment Area Study. Psychol Med 1993;23:709–18.
31. Pratt J, Lenner P, Reynolds EH, Marsden CD: Clonazepam induces decreased serotonergic activity in the mouse brain. Neuropharmacology 1979;18:791–9.
32. Costa E, Giudotti A, Mao CC, Suora A: New concepts on the mechanism of action of benzodiazepines. Life Sci 1975;17:167–86.
33. Gallagher DW: Benzodiazepines: potentiation of a GABA inhibitory response in the dorsal raphe nucleus. Eur J Pharmacol 1978;49: 133–43.
34. Biswas B, Carlson A: The effect of intracerebro-ventricularly administered GABA on brain monoamine metabolism. Naunyn Schmiederbergs Arch Exp Pathol Pharmakol 1977;299:41–6.
35. Schneier F, Campeas R, Fallon B, Hollander E, Coplan J, Davies SO, Fyer AJ, Liebowitz MR: Buspirone in social phobia. Abstracts of the 17th CINP Meeting, Kyoto, Japan. 1990;1:141.
36. Liebowitz MR, Campeas R, Hollander E: MAOIs: impact on social behavior. Psychiatry Res 1987;22:89–90.
37. Potts NLS, Davidson JRT: Social phobia: biological aspects and pharmacotherapy. Prog Neuropsychopharmacol Biol Psychiatry. 1992;16:635–49.