Population pharmacokinetics and pharmacodynamics of warfarin in healthy young adults

European Journal of Pharmaceutical Sciences

Volumn 1, Issue 3, 1993, Pages 151-157

  Pitsiu, Maria ^a   Parker, Eva M ^a   Aarons, Leon ^a   Rowland, Malcolm ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

EM algorithm; Nonlinear regression; NONMEM; Population pharmacodynamics; Population pharmacokinetics; Warfarin

Indexed keywords

BLOOD CLOTTING FACTOR 7; PROTHROMBIN; WARFARIN;

ARTICLE; CONTROLLED STUDY; ENANTIOMER; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHARMACODYNAMICS; STEREOSPECIFICITY; THEORETICAL STUDY;

EID: 0027764325     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-0987(93)90005-U     Document Type: Article

References (21)

1. Stereospecific fluorescence high-performance liquid chromatographic analysis of warfarin and its metabolites in plasma and urine
2. Estimating population kinetics
3. Inhibition by warfarin enantiomers of prothrombin synthesis, protein carboxylation and the regeneration of vitamin K from vitamin K epoxide
4. Interindividual differences in the response to oral anticoagulants
5. Kinetics of warfarin absorption in amn
6. Stereochemical aspects of warfarin in patients receiving chronic therapy
7. Maximum likelihood from incomplete data via the EM algorithm
8. Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship
9. Effect of using warfarin plasma concentrations in Bayesian forecasting of prothrombin-time response
10. Bayes estimates for the linear model (with discussion)
11. Bayesian derived pharmacokinetic/pharmacodynamic variables for warfarin therapy
12. Population pharmacokinetics of racemic warfarin in adult patients
13. Stereoselective interaction of sulfinpyrazone with racemic warfarin and its separated enantiomorphs in man
14. A comparison of the relative sensitivities of factor VII and prothrombin time measurements in detecting drug interactions with warfarin
15. A Bayesian approach to nonlinear random effects models
16. Coupled amidolytic assay for factor VII: its use with a clotting assay to determine the activity state of factor VII
17. Bayesian individualisation of pharmacokinetics: simple implementation and comparison with non-Bayesian methods
18. Comparative effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of warfarin in Man
19. Enoxacin-warfarin interaction: pharmacokinetic and stereochemical aspects
20. Synthetic peptide substrate assays for hemostasis testing