Coordinate Inhibition by Some Antioxidants of TNFα, IL‐1β, and IL‐6 Production by Human Peripheral Blood Mononuclear Cells

Annals of the New York Academy of Sciences

Volumn 696, Issue 1, 1993, Pages 171-184

  EUGUI, ELSIE M ^a   DELUSTRO, BARBARA ^a   ROUHAFZA, SUSSAN ^a   WILHELM, ROBERT ^a   ALLISON, ANTHONY C ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; APOMORPHINE; ASCORBIC ACID; BUTYLATED HYDROXYANISOLE; BUTYLCRESOL; INTERLEUKIN 1BETA; INTERLEUKIN 6; MANNITOL; MEPACRINE; NORAPOMORPHINE; NORDIHYDROGUAIARETIC ACID; QUERCETIN; TETRAHYDROPAPAVEROLINE; TROLOX C; TUMOR NECROSIS FACTOR ALPHA; ZILEUTON;

ANIMAL CELL; ANIMAL EXPERIMENT; CONFERENCE PAPER; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKOCYTE CULTURE; MONONUCLEAR CELL; MOUSE; NONHUMAN;

ANIMALIA;

EID: 0027762594     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1993.tb17150.x     Document Type: Article

References (39)

1. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis
2. Interleukin‐1 and interleukin‐1 antagonism
3. Interleukin‐1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines
4. 2 production by human synovial cells
5. Prostaglandin induced in vascular endothelial cells by interleukin‐1
6. Human monocyte or recombinant interleukin‐1′s are specific for the secretion of a metalloproteinase from chondrocytes
7. Cytokines and bone
8. B cell stimulatory factor‐2 is involved in the differentiation of cytotoxic T lymphocytes
9. IL‐6 is the principal factor produced by synovia of patients with rheumatoid arthritis that induces B‐lymphocytes to secrete immunoglobulin
10. Dissection of the mechanisms of immune injury in rheumatoid arthritis using total lymphoid irradiation
11. Self‐associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and mononuclear cell factors that stimulate collagenase and prostaglandin production by synovial cells
12. IL‐6 is produced by osteoblasts and induces bone resorption
13. Inhibitory effect of TNFα antibodies on synovial cell interleukin‐1 production in rheumatoid arthritis
14. IL‐1 inhibitors block IL‐6 and IL‐8 secretion by fragments of human rheumatoid arthritis synovium
15. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to TNFα: safety, clinical efficacy and control of the acute‐phase response
16. Subcutaneous IL‐1 receptor antagonist in patients with rheumatoid arthritis
17. Antibodies to cachectin/tumor necrosis factor reduce interleukin‐1β and interleukin‐6 appearance during lethal bacteremia
18. Interleukin‐1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia
19. Reactive oxygen intermediates as apparently widely used messengers in the activation of NFkB transcription factor and HIV‐1
20. Redox status influences constitutive or induced NFkB translocation and HIV long terminal repeat activity in human T and monocytic cell lines
21. Rapid and preferential activation of the c‐jun gene during the mammalian UV response
22. Involvement of reactive oxygen intermediates in the induction of c‐jun gene transcription by ionizing radiation
23. Kappa B‐type enhancers are involved in lipopolysaccharide‐mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages
24. Biological and clinical aspects of interleukin‐6
25. Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide‐induced release of tumor necrosis factor
26. N‐Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production
27. Ex vivo lipopolysaccharide‐induced interleukin‐1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties
28. Inhibition of IL‐1β expression in THP‐1 cells by probucol and tocopherol
29. Effects of quinolones on interleukin‐1 production in vitro by human monocytes
30. Effect of a new synthetic free radical scavenger, 2‐octadecyl ascorbic acid, on the mortality in mouse endotoxemia
31. Novel 21‐aminosteroids as potent inhibitors of iron‐dependent lipid peroxidation
32. Clinical efficacy of tirilazad mesylate for treatment of endotoxemia in neonatal calves
33. Monoclonal antibodies to human interleukin‐1β: inhibition of biological activity
34. Long‐acting anti‐rheumatic drugs induce differentiation of cells of the monocyte‐macrophage lineage and alter the expression of cytokines and IL‐1 receptor antagonist
35. Balance of synovial fluid IL‐1β and IL‐1 receptor antagonist and recovery from Lyme arthritis