Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors

Annals of the New York Academy of Sciences

Volumn 696, Issue 1, 1993, Pages 149-170

  LEE, J C ^a   BADGER, A M ^a   GRISWOLD, D E ^a   DUNNINGTON, D ^a   TRUNEH, A ^a   VOTTA, B ^a   WHITE, J R ^a   YOUNG, P R ^a   BENDER, P E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE 1 OXIDE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE 1,1 DIOXIDE; 6,7 DIHYDRO 2 [4 (METHYLSULFINYL)PHENYL] 3 (4 PYRIDYL) 5H PYRROLO[1,2 A]IMIDAZOLE; 6,7 DIHYDRO 2 [4 (METHYLTHIO)PHENYL] 3 (4 PYRIDYL) 5H PYRROLO[1,2 A]IMIDAZOLE; CYTOKINE; DRUG METABOLITE; FLUMIZOLE; ICOSANOID; IMIDAZOLE DERIVATIVE; INTERLEUKIN 1; INTERLEUKIN 8; LEVAMISOLE; SK&F 104343; SK&F 105561; SK&F 105809; SK&F 105942; SK&F 81114; SK&F 86055; SK&F 86096; SKF 105942; SKF 81114; SKF 86055; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; CONFERENCE PAPER; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM CELL; ICOSANOID METABOLISM; IMMUNOLOGICAL PARAMETERS; IMMUNOMODULATION; OSTEOLYSIS;

EID: 0027761036     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1993.tb17149.x     Document Type: Article

References (79)

1. Cytokines: coordinators of inflammatory responses
2. Interleukin‐1 and interleukin‐1 antagonism
3. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis
4. Cytokines and other mediators in rheumatoid arthritis
5. Pharmacological modulation of interleukin‐1
6. An interleukin 1 inhibitor from human monocytes: production and characterization of biological properties
7. Regulation of alloreactivity in vivo by a soluble form of the interleukin‐1 receptor
8. A tumor necrosis factor (TNF) receptor‐IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity
9. Glucocorticoids selectively inhibit the transcription of interleukin‐1 gene and decrease the stability of IL‐1 β mRNA
10. Cytokine modulation as a medicinal chemistry target
11. An assay for the detection of interleukin‐1 synthesis inhibitors: effects of anti‐rheumatic drugs
12. The effect of gold sodium thiomalate and auranofin on lipopolysaccharide‐induced interleukin‐1 production by blood monocytes in vitro: variation in healthy subjects and patients with arthritis
13. The influence of lipoxygenase inhibitors on the in vitro production of human leukocyte pyrogen and lymphocyte activity factor (IL‐1)
14. Inhibition of monocyte IL‐1 production by the anti‐inflammatory compound, SK&F 86002
15. Effect of SK&F 86002 on cytokine production by human monocytes
16. Inhibition of human monocyte IL‐1 production by SK&F 86002
17. A novel heterodimeric cysteine protease is required for interleukin‐1 β processing in monocytes
18. Preparation and antiinflammatory activity of some nonacidic trisubstituted imidazoles
19. Novel broad‐spectrum anthelmintics. Tetramisole and related derivatives of 6‐arylimidazo[2,1‐b]thiazole
20. 5,6‐Diaryl‐2,3‐dihydroimidazo[2,1b]thiazoles
21. Antiinflammatory activity of 5,6‐diaryl‐2,3‐dihydroimidazo‐[2,1‐b]thiazoles
22. SK&F 86002: a structurally novel anti‐inflammatory agent that inhibits lipoxygenase‐ and cyclooxygenase‐mediated metabolism of arachidonic acid
23. Pharmacokinetics and metabolism of SK&F 86002 in male and female spraguedawley rats
24. Pharmacology of the pyrroloimidazole, SK&F 105809‐II. Antiinflammatory activity and inhibition of mediator production in vivo
25. Pharmacology of the pyrroloimidazole, SK&F 105809‐I
26. Pharmacological profile of SK&F 105809, a dual inhibitor of arachidonic acid metabolism
27. Cyclic nucleotides differentially regulate the synthesis of tumor necrosis factor α and interleukin‐1 β by human mononuclear cells
28. The specific type IV phosphodiesterase inhibitor rolipram suppress tumor necrosis factor production by human mononuclear cells
29. Effects of cAMP levels on IL‐1 production in human monocytes
30. Inhibition of interleukin‐1 (IL‐1) and tumor necrosis factor (TNF) production by the pyridinyl imidazole compounds is independent of cAMP elevating mechanisms
31. Effects of pyridinyl imidazole compounds on murine TNF‐α production
32. Beneficial effects of SK&F 105809, a novel cytokine‐suppressive agent, in murine models of endotoxin shock
33. Neutrophil attractant/activation protein‐1 and monocyte chemoattractant protein‐1 in rabbit
34. Endothelial cell gene expression of neutrophil chemotactic factor by TNFα, LPS and IL‐1β
35. The effect of cytokines and chemotactic agonists on the migration of T lymphocytes into skin
36. Endothelial cell binding of NAP‐1/IL‐8: role in neutrophil emigration
37. Bicyclic imidazoles inhibit IL‐1 and TNF production at the protein level
38. Kappa B—type enhancers are involved in lipopolysaccharide‐mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages
39. Coordinate regulation of TNF biosynthesis at the levels of transcription and translation
40. A conserved AU‐rich sequence from the 3′ untranslated region of gm‐CSF mRNA mediates selective mRNA degradation
41. The scanning model for translation: an update
42. Cytokines and bone
43. Action of recombinant interleukin‐1, interleukin‐2 and interferon gamma on bone resorption in vitro
44. Stimulation of bone resorption and inhibition of bone formation in vitro by human necrosis factors
45. Infusion of interleukin‐1 α and β causes hypercalcemia in normal mice
46. Tumor necrosis factor α (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin‐mediated mechanism
47. Tumor necrosis factors α and β induce osteoblastic cells to stimulate bone resorption
48. Interleukin‐1 and tumor necrosis factor stimulate the formation of human osteoclast‐like cells
49. Spontaneous release of interleukin‐1 from human blood monocytes reflects bone formation in idiopathic osteoporosis
50. Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin‐1 release
51. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells
52. Bone resorption in tissue culture. Factors influencing the response to parathyroid hormone
53. Class II MHC molecules and the HIV gp120 envelope protein interact with functionally distinct regions of the CD4 molecule
54. Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493
55. Neutrophil recruitment by tumor necrosis factor from mast cells in immune complex peritonitis
56. Analgetic activity of SK&F 105809, a dual inhibitor of arachidonic acid metabolism
57. Effect of inhibitors of eicosanoid metabolism in murine collagen‐induced arthritis
58. Galactosamine‐induced sensitization to the lethal effects of endotoxin
59. Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxic shock: inhibition of tumor necrosis factor as a possible mechanism of action
60. Endotoxin‐responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level
61. Translational blockade imposed by cytokine‐derived UA‐rich sequences
62. Identification of a common nucleotide sequence in the 3′‐untranslated region of mRNA molecules specifying inflammatory mediators
63. Translational control mediated by UA‐rich sequences
64. Stimulation of interleukin‐1 α and interleukin 1 β production in human monocytes by protein phosphatase 1 and 2A inhibitors
65. Stimulation of tumor necrosis factor α production in human monocytes by inhibitors of protein phosphatase 1 and 2A
66. Transgenic mice expressing human tumor necrosis factor: a predictive genetic model of arthritis
67. A receptor for the immunosuppressant FK506 is a cis‐trans peptidyl‐prolyl isomerase
68. Identification and isolation of a membrane protein necessary for leukotriene production
69. The effect of antirheumatic drugs on interleukin 1 (IL‐1) activity and IL‐1 and IL‐1 inhibitor production by human monocytes
70. Inhibition of interleukin 1 synthesis by Tenidap; a new drug for arthritis
71. Cytokine inhibition by a novel steroid, mometasone furoate
72. Inhibition by Probucol of interleukin‐1 secretion and its implication in artherosclerosis
73. Oxygen radical scavengers selectively inhibit interleukin 8 in human whole blood
74. Cytokine release from microglia; differential inhibition by pentoxifylline and dexamethasone
75. Tetrandrine, a plant alkaloid, inhibits the production of tumor necrosis factor α (cachectin) by human monocytes
76. Immunological and anti‐inflammatory effects of chlarithromycin: inhibition of interleukin 1 production of murine peritoneal macrophages. Drugs Exp
77. Interleukin 10 (IL‐10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL‐10 produced by monocytes