Sonic hedgehog mediates the polarizing activity of the ZPA

Cell

Volumn 75, Issue 7, 1993, Pages 1401-1416

  Riddle, Robert D ^a   Johnson, Randy L ^a   Laufer, Ed ^a   Tabin, Cliff ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; SIGNAL PEPTIDE;

ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; EMBRYO; GENE ACTIVATION; GENE EXPRESSION; LIMB BUD; LIMB DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CHICK EMBRYO; COMPARATIVE STUDY; DNA PRIMERS; EMBRYONIC INDUCTION; EXTREMITIES; GENE EXPRESSION; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRETINOIN;

ANIMALIA; ERINACEIDAE; VERTEBRATA;

EID: 0027760995     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90626-2     Document Type: Article

References (61)

1. Basic local alignment search tool
2. We may not have a morphogen
3. A comprehensive set of sequence analysis programs for the VAX
4. The bicoid protein is a positive regulator of hunchback transcription in early Drosophila embryo
5. Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation
6. Sonic hedgehog a member of a family of putative signaling molecules is implicated in the regulation of CNS polarity
7. Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo
8. Retroviral infection coupled with tissue transplantation limits gene transfer in the chicken embryo
9. A series of normal stages in the development of the chick embryo
10. Maps of strength of positional signalling activity in the developing chick wing bud
11. Positional signalling by Hensen's node when grafted to the chick limb bud
12. The spatial and temporal distribution of polarizing activity in the flank of the pre-limb bud stages in the chick embryo
13. Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors
14. The molecular genetics of embryonic pattern formation in Drosophila
15. Segment polarity genes and cell patterning within the Drosophila body segment
16. Boundaries and fields in early embryos
17. Expression of the homeobox Hox-4 genes and the specification of position in chick wing development
18. Diffusible factors in vertebrate embryonic induction
19. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
20. A functionally conserved homolog of the Drosophila segment polarity gene hedgehog is expressed in tissues with polarizing activity in Zebrafish embryos
21. A simple method for displaying the hydropathic character of a protein
22. Recognition of nascent polypeptides for targeting and folding
23. Factoring in the limb
24. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
25. Requirements for hedgehog, a segment polarity gene, in patterning larval and adult cuticle of Drosophila
26. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterns in Drosophila
27. Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations
28. FGF-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse
29. FGF-4 and BMP-2 have opposite effects on limb growth
30. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
31. Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development
32. Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud
33. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
34. Retroviral expression of FGF-2 (bFGF) affects patterning in chick limb buds
35. Whole-mount in situ hybridization in the mouse embryo: gene expression in three dimensions
36. DNA sequencing with chain termination inhibitors
37. Differential expression of multiple fork head-related genes during gastrulation and axial pattern formation in the mouse embryo
38. Ectodermal-mesenchymal interaction in the origin of limb symmetry
39. New insights into the problem of pattern regulation in the limb bud of the chick embryo
40. Evidence for a positional memory in the development of the chick wing bud
41. Hensen's node, but not other biological signallers can induce supernumerary digits in the developing chick limb bud
42. The effects of local application of retinoic acid to the anterior margin of the developing chick limb
43. Vitamin A and the control of pattern in developing limbs
44. Localization of Hst1 transcripts to the apical ectodermal ridge in the mouse embryo
45. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation
46. Retinoids, homeoboxes, and growth factors: toward molecular models for limb development
47. Why we have (only) five fingers per hand: Hox genes and the evolution of paired limbs
48. Hox genes and serial homology
49. Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
50. Identification and spatial distribution of retinoids in the developing chick limb bud
51. The number of polarizing region cells required to specify additional digits in the developing chick wing
52. Local application of retinoic acid to the limb bud mimics the action of the polarizing region
53. A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development
54. Positional signalling and specification of digits in chick limb morphogenesis
55. FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro
56. A new method for predicting signal sequence sites
57. Polarizing activity and retinoid synthesis in the floor plate of the neural tube
58. Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud
59. Experimental biology and assay of RNA tumor viruses
60. Positional information and the spatial pattern of cellular differentiation