Effects of antiandrogens on transformation and transcription activation of wild-type and mutated (LNCaP) androgen receptors

Journal of Steroid Biochemistry and Molecular Biology

Volumn 46, Issue 6, 1993, Pages 731-736

  Berrevoets, C A ^a   Veldscholte, J ^a   Mulder, E ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; BICALUTAMIDE; CYPROTERONE ACETATE; HYDROXYFLUTAMIDE; METRIBOLONE;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; GENETIC TRANSFECTION; IMMUNOBLOTTING; KIDNEY CELL; NONHUMAN; TRANSCRIPTION REGULATION;

ADENOCARCINOMA; ALANINE; AMINO ACID SEQUENCE; ANDROGEN ANTAGONISTS; ANILIDES; ANIMAL; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CYPROTERONE ACETATE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUTAMIDE; HUMAN; MALE; METRIBOLONE; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RECOMBINANT PROTEINS; THREONINE; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMATION, GENETIC; TUMOR CELLS, CULTURED;

ANIMALIA; FELIS CATUS;

EID: 0027756942     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-0760(93)90313-L     Document Type: Article

References (24)

1. Gene regulation by steroid hormones
2. Steroid receptor family: Structure and function
3. Pharmacology of antiandrogens
4. The design and use of sex-steroid antagonists
5. Steroid antagonists as nuclear receptor blockers
6. Mammalian progesterone receptor shows differential sequence specificity to sulfhydril group modifying agents, when bound to agonist and antagonist ligands
7. Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells
8. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
9. Inhibition of estrogen receptor DNA binding by the pure antiestrogen ICI-164,384 appears to be mediated by impaired receptor dimerization
10. Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells
11. Receptors bound to antiprogestin form abortive complexes with hormone responsive elements
12. Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element
13. LNCaP model of human prostatic carcinoma
14. Regulation of growth and epidermal growth factor receptor levels of prostate tumor cells by different steroids
15. A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens
16. Antiandrogens and the mutated receptor of LNCaP cells: Differential effects on binding affinity, heat-shock protein interaction, and transcription activation
17. Many transcription factors interact synergistically with steroid receptors
18. A highly sensitive, mixed-phase assay for chloramphenicol acetyl transferase activity in transfected cells
19. Hormone-induced dissociation of the androgen receptor-heat-shock protein complex: Use of a new monoclonal antibody to distinguish transformed from nontransformed receptors
20. Epitope prediction and confirmation for the human androgen receptor: Generation of monoclonal antibodies for multi-assay performance following the synthetic peptide strategy
21. Modulation of oestrogen receptor activity by oestrogens and anti-oestrogens
22. Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells
23. Mechanism of antihormone action
24. Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation: Specificity for steroids and antihormones