Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Cell

Volumn 75, Issue 7, 1993, Pages 1417-1430

  Echelard, Yann ^a   Epstein, Douglas J ^a   St Jacques, Benoit ^a   Shen, Liya ^b   Mohler, Jym ^c   McMahon, Jill A ^a   McMahon, Andrew P ^a  

^a HARVARD UNIVERSITY   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c Barnard College of Columbia University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CELL POLARITY; CENTRAL NERVOUS SYSTEM; EMBRYO; GENE ACTIVATION; GENE EXPRESSION; MOUSE; NONHUMAN; NOTOCHORD; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CENTRAL NERVOUS SYSTEM; CLONING, MOLECULAR; COMPARATIVE STUDY; DNA PRIMERS; EXTREMITIES; FEMALE; GENE EXPRESSION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T;

ANIMALIA; ERINACEIDAE; MUS MUSCULUS;

EID: 0027756145     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90627-3     Document Type: Article

References (59)

1. Roles of wingless in patterning the larval epidermis of Drosophila
2. Perturbation of neuronal differentiation and axon guidance in the spinal cord of mouse embryos lacking a floor plate: analysis of Danforth's short-tail mutation
3. Neuroanatomical and functional analysis of neural tube formation in notochordless Xenopus embryos; laterality of the ventral spinal cord is lost
4. Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis
5. Transcription of H-2 and Qa genes in embryonic and adult mice
6. Role of the floor plate in axonal patterning in the zebrafish CNS
7. The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system
8. Multiple nodes of engrailed regulation in the progression towards cell fate determination
9. The effect of the floor plate on pattern and polarity in the developing central nervous system
10. Evidence that Hensen's node is a site of retinoic acid synthesis
11. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
12. Positional signaling by Hensen's node when grafted to the chick limb bud
13. Spatially restricted hedgehog activity controls wingless transcription in the Drosophila embryo
14. Regulation of wingless transcription in the Drosophila embryo
15. Role of the Drosophila patched gene in positional signaling
16. Floor plate-derived signals and the control of neural cell pattern in vertebrates
17. The developmental significance of the floor-plate of the brain and spinal cord
18. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
19. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
20. The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
21. Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo
22. The Wnt family of developmental regulators
23. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
24. − mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
25. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila
26. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
27. A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
28. Wnt genes
29. Mutations affecting segment number and polarity in Drosophila
30. Hepatocyte nuclear factor 3β contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein
31. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
32. Induction of floor plate differentiation by contact-dependent, homeogenetic signals
33. Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant
34. Mesodermal control of neural cell identity: floor plate induction by the notochord
35. Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate
36. Sonic hedgehog mediates the ZPA of polarizing activity
37. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
38. Midline cells and the organization of the vertebrate neuraxis
39. Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis
40. Differential expression of multiple fork head-related genes during gastrulation and axial pattern formation in the mouse embryo
41. Notochordal induction of cell wedging in the chick neural plate and its role in neural tube formation
42. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation
43. Retinoids, homeoboxes, and growth factors: toward molecular models for limb development
44. Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication
45. Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
46. Chemotropic guidance of developing axons in the mammalian central nervous system
47. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
48. Positional signaling by mouse limb polarizing region in the chick wing bud
49. Effect of a notochordal implant on the early morphogenesis of the neural tube and neuroblasts: histometrical and histological results
50. A new method for predicting signal sequence cleavage sites
51. Polarizing activity and retinoid synthesis in the floor plate of the neural tube
52. Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression
53. Whole mount in situ hybridization of vertebrate embryos
54. Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo
55. A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression
56. Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate
57. Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord