Field stimulation-induced noradrenaline release from guineapig atria is modulated by prejunctional α2-adrenoceptors and protein kinase C

Basic Research in Cardiology

Volumn 88, Issue 6, 1993, Pages 545-556

  Brasch, H ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

2 adrenoceptors; Guinea pig atrium; noradrenaline release; phorbol esters; protein kinase C

Indexed keywords

4 O METHYLPHORBOL 13 ACETATE 12 MYRISTATE; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; GUANINE NUCLEOTIDE BINDING PROTEIN; IDAZOXAN; N ETHYLMALEIMIDE; NORADRENALIN; PHORBOL 13 ACETATE 12 MYRISTATE; POLYMYXIN B; PROTEIN KINASE C; TETRODOTOXIN; TETRYLAMMONIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GUINEA PIG; HEART ATRIUM; MALE; MUSCLE ACTION POTENTIAL; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; NORADRENALIN RELEASE; SYMPATHETIC NERVE;

ANIMAL; ELECTRIC STIMULATION; ETHYLMALEIMIDE; FEMALE; GUINEA PIGS; HEART ATRIUM; INTERCELLULAR JUNCTIONS; MYOCARDIUM; NOREPINEPHRINE; PROTEIN KINASE C; RECEPTORS, ADRENERGIC, ALPHA; REFRACTORY PERIOD, NEUROLOGIC;

EID: 0027756092     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/BF00788873     Document Type: Article

References (28)

1. Islet-activating protein (pertussis toxin) diminishes α2-adrenoceptors-mediated effects on noradrenaline release
2. N-ethylmaleimide (NEM) diminishes α2-adrenoceptor-mediated effects on noradrenaline release
3. Enhancement of noradrenaline release by 12-O-tetradecanoyl-phorbol-13-acetate, an, activator of protein kinase C
4. Protein kinase C activation and α2-adrenoceptor-modulated release of noradrenaline
5. A detailed study on the effects of protein kinase C activation on alpha-2 adrenoceptor-coupled modulation of norepinephrine release in hippocampus
6. Role of auto-inhibitory feedback in cardiac sympathetic transmission assessed by simulatneous measurements of changes in3H-efflux and atrial rate in guinea-pig atrium
7. Pulse duration and α2-adrenoceptors modify noradrenaline release from fieldstimulated atria
8. No influence of prejunctional α2-adrenoceptors on the effects of nicotine and tyramine in guinea-pig atria
9. Effects of the cardiotonic drug ARL-115 on the release of noradrenaline from the cat atrium, the binding of3H-ouabain to plasma membranes and the movements of calcium in mitochondria
10. No effect of pertussis toxin on peripheral prejunctional α2-adrenoceptor-mediated responses and on endothelium-dependent relaxations in the rat
11. Prejunctional beta-adrenoceptors, angiotensin II and neuropeptide Y receptors on sympathetic nerves in mouse atria are linked to N-ethylmaleimide-susceptible G-proteins
12. Role of calcium channels and protein kinase C for release of norepinephrine and neuropeptide Y
13. The influence of activation or inhibition of, protein kinase C on the release of radioactivity from rat isolated atria labelled with [3H]-noradrenaline
14. Uncoupling of alpha-adrenoceptor-mediated inhibition of human platelet adenylate cyclase by N-ethylmaleimide
15. Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase
16. Cobra polypeptide cytotoxin I and marine worm polypeptide cytotoxin A-IV are poten and selective inhibitors of phospholipid-sensitive Ca2+-dependent protein kinase
17. Effect of, islet-activating protein (IAP) on contractile responses of rat vas deferens: evidence for participation of Ni (inhibitory GTP binding regulating protein) in the α2-adrenoceptor-mediated response
18. α-Adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating
19. Prejunctional α2-adrenoceptors in mouse atria function through G-proteins which are sensitive to N-ethylmaleimide, but not pertussis toxin
20. Pertussis toxin does not attenuate α2-adrenoceptor mediated inhibition of noradrenaline release in mouse atria
21. Effect of phorbol esters and polymyxin B on modulation of noradrenaline release in mouse atria
22. Effect of phorbol ester and pertussis toxin on the enhancement of noradrenaline release by angiotensin II in mouse atria
23. Differential effect of pertussis toxin on pre- and post-junctional alpha 2-adrenoceptors in the cardiovascular system of the pithed rat
24. Structure and function of α-adrenoceptors
25. On electrophysiological responses to phorbol esters which stimulate protein kinase C in rabbit sino-atrial node cells
26. Activation of protein kinase C potentiates norepinephrine release from sinus node
27. Regulation of noradrenaline release by presynaptic receptor systems