The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders

International Clinical Psychopharmacology

Volumn 8, Issue , 1993, Pages 41-46

  Miller, H L ^a,b   Delgado, P L ^a   Charney, D ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; DESIPRAMINE; DOPAMINE; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; MIANSERIN; MONOAMINE OXIDASE INHIBITOR; NORADRENALIN; NORTRIPTYLINE; SEROTONIN; TRAZODONE; TRYPTOPHAN;

DEPRESSION; HUMAN; MENTAL DISEASE; PRIORITY JOURNAL; REVIEW; SEROTONINERGIC SYSTEM;

AFFECT; ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSIVE DISORDER; DOPAMINE; HUMAN; NOREPINEPHRINE; PERSONALITY INVENTORY; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; TRYPTOPHAN;

EID: 0027752763     PISSN: 02681315     EISSN: 14735857     Source Type: Journal    
DOI: 10.1097/00004850-199311002-00006     Document Type: Article

References (11)

1. Charney DS and Delgado PL (1992) Current concepts ot serotonin in neuronal (unction and the pathophysiology of depression). In: Experimental Approaches to Anxiety and Depression (Eds JM Elliott, DJ Heal and CA Marsden), pp. 197-218. Wiley and Sons, London.
2. Delgado PL., Charney DS, Price LH, Landis H and Heninger GR (1989) Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjects. Life Sciences, 45, 2323-2332.
3. Delgado PL, Charnev DS, Price LH, Agbajanian GK, Landis H and Heninger OR (1990) Serotonin function and the mechanism of antidepressant action: reversal of antidepressant induced remission by rapid depletion of plasma tryptophan. Archives of General Psychiatry, 47, 411-418.
4. Delgado PL, Price LH, Miller HL, Salomon RM, Licinio J, Krystal JH, Heninger GR and Charney DS (1991) Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression. Psychopharmacology Bulletin, 27, 321-330.
5. Delgado PL, Price LH, Heninger GR and Charney DS (1992) Neurochemistry of affective disorders. In: Handbook of Affective Disorders (Ed ES Paytkel), pp. 219-253. Churchill Livingstone, New York.
6. Delgado PL, Miller HL, Salomon RM, Licinio J, Heninger GR, Gelenberg AJ and Charney DS (1993) Alpha-methyl-para- tyrosine (AMPT) depletion of catecholamines in treated depressed patients. Abstract, Society of Neuroscience Meeting. Washington, D.C.
7. Miller HL, Delgado PL, Salomon RM, Wong M and Charney DS (1993) Effects of AMPT in drug free depressed patients. Society for Neuroscience Abstracts. Vol 19, p. 1884.
8. Shopsin B, Friedman E and Gershon S (1976) Parachlorophenyl- alanine reversal of tranylcypromine effects in depressed patients. Archives of General Psychiatry, 33, 811-819.
9. Shopsin B, Gershon S, Goldstein M, Friedman E and Wilk S (1975) Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients. Psychopharmacology Communications, 1, 239-249.
10. Young SN, Smith SE, Pihi R, Ervin FR (1985) Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology, 87, 173-177.
11. Young SN, Ervin FR, Pihl RO and Finn P (1989) Biochemical aspects of tryptophan depletion in primates. Psychopharmacology, 98, 508-511.