In vitro evolution of functional nucleic acids: high-affinity RNA ligands of HIV-1 proteins

Gene

Volumn 137, Issue 1, 1993, Pages 33-39

  Tuerk, Craig ^a   MacDougal Waugh, Sheela ^a  

^a Nexagen   (United States)

Author keywords

Antiviral therapy; Cycles of selection; Pseudoknot; SELEX; Tat

Indexed keywords

ANTIVIRUS AGENT; LIGAND; NUCLEIC ACID; RNA; RNA LIGAND; UNCLASSIFIED DRUG; VIRUS PROTEIN;

CONFERENCE PAPER; DRUG DESIGN; DRUG DEVELOPMENT; EVOLUTION; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

BASE SEQUENCE; GENE PRODUCTS, REV; GENE PRODUCTS, TAT; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; LIGANDS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; RNA; RNA-DIRECTED DNA POLYMERASE; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0027751625     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1119(93)90248-2     Document Type: Article

References (27)

1. Gene therapy: intracellular immunization
2. HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA
3. Regulatory pathways governing HIV-1 replication
4. Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
5. Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV
6. HIV-1 Tat protein binds trans-activation-responsive region (TAR) RNA in vitro
7. The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization
8. HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA
9. Rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA
10. Regulation of human immunodeficiency virus env expression by the rev gene product
11. HIV-1 regulator of virion expression (rev) protein binds to an RNA stem-loop structure located within the rev response element region
12. Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the rev response element
13. 2 as a primer in an in vitro primer-utilization assay
14. Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells
15. HIV-1 Structural gene expression requires binding of the rev trans-activator to its RNA target sequence
16. Cationic liposomemediated RNA transfection
17. Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus
18. HIV-1 Tat protein trans-activates in vitro
19. Applying the PDR principle to AIDS
20. The concept of parasite-derived resistance-deriving resistance genes from the parasite's own genome
21. Preformed ribozyme destroys tumour necrosis factor mRNA in human cells
22. A second post-transcriptional transactivator gene required for HTLV-III replication
23. Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication
24. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
25. Autogenous translational operator recognized by bacteriophage T4 DNA polymerase
26. RNA pseudoknot inhibitors of HIV-1 reverse transcriptase
27. In vitro evolution of functional ligands: RNA ligands of the HIV-1 Rev protein