Cd40l: A multi-functional ligand

Seminars in Immunology

Volumn 5, Issue 6, 1993, Pages 404-412

  Armitage, Richard J ^a   Maliszewski, Charles R ^a   Alderson, Mark R ^a   Grabstein, Kenneth H ^a   Spriggs, Melanie K ^a   Fanslow, William C ^a  

^a AMGEN INC   (United States)

Author keywords

CD40 ligand; Hyper IgM syndrome; Immunoglobulin secretion; Isotype switching

Indexed keywords

ANTIGENS, DIFFERENTIATION, B LYMPHOCYTE; B LYMPHOCYTE ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN;

ANIMAL; B LYMPHOCYTE; CELL COMMUNICATION; HUMAN; IMMUNOLOGY; IMMUNOPATHOLOGY; LYMPHOCYTE ACTIVATION; PHYSIOLOGY; REVIEW; T LYMPHOCYTE;

ANIMAL; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; CD40 LIGAND; CELL COMMUNICATION; HUMAN; IMMUNOLOGIC DISEASES; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; T-LYMPHOCYTES;

EID: 0027745154     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1993.1046     Document Type: Article

References (81)

1. Chesnut RW, Grey HM (1981) Studies on the capacity of B cells to serve as antigen-presenting cells. J Immunol 126:1075-1079
2. Lanzavecchia A (1985) Antigen-specific interaction between T and B cells. Nature 314:537-539
3. Bretscher P, Cohn M (1970) A theory of self-nonself discrimination. Science 169:1042-1049
4. Katz DH, Hamaoka T, Dorf ME, Benacerraf B (1973) Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions. Proc Natl Acad Sci USA 70: 2624-2630
5. Andersson J, Schreier MH, Melchers F (1980) T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level. Proc Natl Acad Sci USA 77:1612-1616
6. Whalcn BJ, Tony H-P, Parker DC (1988) Characterization of the effector mechanism of help for antigen-presenting and bystander resting B cell growth mediated by I A-restricted Th2 helper T cell clones. J Immunol 141:2230
7. Owens T (1988) A noncognate interaction with anti-receptor antibody-activated helper T cells induces small resting murine B cells to proliferate and to secrete antibody. Eur J Immunol 18:395-401
8. Hirohata S, Jelinek DF, Lipsky PE (1988) T cell-dependent activation of B cell proliferation and differentiation by immobilized monoclonal antibodies to CD3. J Immunol 140:3736-3744
9. Julius MH, Rammensee HG, Ratcliffe MJ, Lamers MC, Langhorne J, Kohler G (1988) The molecular interactions with helper T cells which limit antigen-specific B cell differentiation. Eur J Immunol 18:381-386
10. Noelle RJ, Snow EC (1991) T helper cell-dependent B cell activation. FASEB J 5:2770-2706
11. Noelle RJ, Daum J, Bartlett WC, McCann J, Shepherd DM (1990) Cognate interactions between helper T cells and B cells. V. Reconstitution of helper T cell function using purified plasma membranes from activated Thl and Th2 helper T cells and lymphokines. J Immunol 146:1118-1124
12. Brian AA (1988) Stimulation of B-cell proliferation by membrane-associated molecules from activated T cells. Proc Natl Acad Sci USA 85:564-568
13. Sekita K, Straub C, Hoessli D, Zubler RH (1988) B cell-stimulating activity of lymphoid cell membrane fractions. Eur J Immunol 18:1405-1410
14. Hodgkin PD, Yamashita LC, Coffman RL, Kehry MR (1990) Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. J Immunol 145:2025-2034
15. Clark EA, Lane PJ (1991) Regulation of human B-cell activation and adhesion. Annu Rev Immunol 9:97-127
16. Clark EA, Ledbetter J A (1986) Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc Natl Acad Sci USA 83: 4494-4498
17. Stamenkovic I, Clark EA, Seed B (1989) A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J 8:1403-1410
18. Smith CA, Davis T, Anderson D, Solam L, Beckmann MP, Jerzy R, Dower SK, Cosman D, Goodwin RG (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248:1019-1023
19. Mallett S, Barclay AN (1991) A new superfamily of cell surface proteins related to the nerve growth factor receptor. Immunol Today 12:220-223
20. Diirkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H (1992) Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin’s disease. Cell 68:421-427
21. Clark EA (1990) CD40: A cytokine receptor in search of a ligand. Tiss Antigens 36:33-36
22. Banchereau J, de Paoli P, Valle A, Garcia E, Rousset F (1991) Long term human B cell lines dependent on interleukin-4- and antibody to CD40. Science 251:70-72
23. Jabara HH, Fu SM, Geha RS, Vercelli D (1990) CD40 and IgE: Synergism between anti-CD40 monoclonal antibody and interleukin-6 in the induction of IgE synthesis by highly purified human B cells. J Exp Med 172: 1861-1864
24. Zhang K, Clark EA, Saxon A (1991) CD40 stimulation provides an IFN-γ-independent and IL-4-dependent differentiation directly to human B cells for IgE production. J Immunol 146:1836-1842
25. + T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signalling pathways. J Immunol 147:8-13
26. Rousset F, Garcia E, Banchereau J (1991) Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J Exp Med 173:705-710
27. Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu DH, Kastelein R, Moore KW, Banchereau J (1992) Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 89:1890-1893
28. Defrance T, Vanbervliet B, Briere F, Durand I, Rousset F, Banchereau J (1992) Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J Exp Med 175:671-682
29. Liu YJ, Mason DY, Johnson GD, Abbot S, Gregory CD, Hardie DL, Gordon J, Mac Lennan IC (1991) Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur J Immunol 21:1905-1910
30. Uckun FM, Schieven GL, Diberdik I, Chandan-Langlie M, Tuel-Ahlgren L, Ledbetter JA (1991) Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny. J Biol Chem 266:17478-17485
31. Liu YJ, Joshua DE, Williams GT, Smith CA, Gordon J, MacLennon ICM (1989) Mechanism of antigen-driven selection in germinal centres. Nature 342:929-931
32. Liu YJ, Cairns JA, Holder MJ, Abbot SD, Jansen KU, Bonnefoy JY, Gordon J, MacLennan IC (1991) Recombinant 25-kDa CD23 and interleukin la promote the survival of germinal center B cells: Evidence for bifurcation in the development of centrocytes rescued from apoptosis. Eur J Immunol 21:1107-1114
33. Lundgren M, Persson U, Larsson P, Magnusson C, Smith CI, Hammarstrom L, Severinson E (1989) Interleukin 4 induces synthesis of IgE and IgG4 in human B cells. Eur J Immunol 19:1311-1315
34. Pene J, Rousset F, Briere F, Chretien I, Bonnefoy JY, Spits H, Yokota T, Arai N, Arai K, Banchereau J, de Vries JE (1988) IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons 7 and a and prostaglandin E2. Proc Natl Acad Sci USA 85:6880-6884
35. Fanslow WC, Anderson D, Grabstein KH, Clark EA, Cosman D, Armitage RJ (1992) Soluble forms of CD40 inhibit biological responses of human B cells. J Immunol 149:655-660
36. Vercelli D, Jabara HH, Arai K, Geha RS (1989) Induction of human IgE synthesis requires interleukin-4 and T/B celt interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med 169: 1295-1307
37. Pene J, Rousset F, Briere F, Chretien I, Paliard X, Banchereau J, Spits H, De Vries JE (1988) IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFNγ. J Immunol 141:1218-1224
38. Gauchat JF, Lebman DA, Coffman RL, Gascan H, de Vries JE (1990) Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 172:463-473
39. Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A (1992) A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA 89:6550-6554
40. Armitage RJ, Sato TA, Macduff BM, Clifford KN, Alpert AR, Smith CA, Fanslow WC (1992) Identification of a source of biologically active CD40 ligand. Eur J Immunol 22:2071-2076
41. McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI, Copeland NG, Huebner K, Croce CM, Cannizzarro LA, Benjamin D, Dower SK, Spriggs MK, Sims JE (1991) A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J 10:2821-2832
42. Armitage RJ, Fanslow WC, Strockbine L, Sato TA, Clifford KN, Macduff BM, Anderson DM, Gimpel SD, Davis-Smith T, Maliszewski CR, Clark EA, Smith CA, Grabstein KH, Cosman D, Spriggs MK (1992) Molecular and biological characterization of a murine ligand for CD40. Nature 357:80-82
43. Spriggs MK, Armitage RJ, Strockbine L, Clifford KN, Macduff BM, Sato TA, Maliszewski CR, Fanslow WC (1992) Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J Exp Med 176:1543-1550
44. Graf D, Korthauer U, Mages HW, Senger G, Kroczek RA (1992) Cloning of TRAP, a ligand for CD40 on human T cells. Eur J Immunol 22:3191-3194
45. Hollenbaugh D, Grosmaire LS, Kullas CD, Chalupny NJ, Braesch-Andersen S, Noelle RJ, Stamenkovic I, Ledbetter JA, Aruffo A (1992) The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: Expression of a soluble form of gp39 with B cell co-Stimulatory activity. EMBO J 11:4313-4321
46. Farrah T, Smith CA (1992) Emerging cytokine family. Nature 358:26
47. Eck MJ, Uhsch M, Rinderknecht E, de Vos AM, Sprang SR (1992) The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution. J Biol Chem 267:2119-2122
48. Paulie S, Rosen A, Ehlin-Henriksson B, Braesch-Andersen S, Jakobsen E, Koho H, Perlmann P (1989) The human B lymphocyte and carcinoma antigen, CDw40, is a phospho-protein involved in growth signal transduction. J Immunol 142:590-595
49. Grabstein KH, Maliszewski CR, Shanebeck K, Sato TA, Spriggs MK, Fanslow WC, Armitage RJ (1993) The regulation of T cell dependent antibody formation in vitro by CD40 ligand and interleukin 2. J Immunol 150:3141-3147
50. Lane P, Traunecker A, Hubele S, Inui S, Lanzavecchia A, Gray D (1992) Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur J Immunol 22:2573-2578
51. Lederman S, Yellin MJ, Inghirmi G, Lee JJ, Knowles DM, Chess L (1992) Molecular interactions mediating T-B lymphocvte collaboration in human lymphoid follicles. J Immunol 149:3817-3826
52. + T cells that induces contact-dependent B cell differentiation (help). J Exp Med 175:1091-1101
53. Maliszewski CR, Grabstein K, Fanslow WC, Armitage R, Spriggs MK, Sato TA (1993) Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: Cooperative effects of cytokines. Eur J Immunol 23:1044-1049
54. Noelle RJ, Krammer PH, Ohara J Uhr JW, Vitetta ES (1984) Increased expression of la antigens on resting B cells: A new role for B cell growth factor. Proc Natl Acad Sci USA 81:6149-6153
55. Rochm NW, Leibson HJ, Zlotnick A, Kappler J, Marrack R, Cambier JC (1984) Interleukin-induced increase in la expression by normal mouse B cells. J Exp Med 160:679-694
56. Hudak SA, Gollnick SO, Conrad DH, Kehry MR (1987) B cell stimulatory factor-1 (interleukin 4) increases expression of the Fc receptor for IgE on mouse B cells. Proc Natl Acad Sci USA 84:4606-4610
57. Shapira SK, Vercelli D, Jabara HH, Fu SM, Geha RS (1992) Molecular analysis of the induction of immunoglobulin E synthesis in human B cell by interleukin 4 and engagement of CD40 antigen. J Exp Med 175:289-292
58. Gauchat JF, Aversa G, Gascan H, de Vries JE (1992) Modulation of IL-4 induced germline epsilon RNA synthesis in human B cells by tumor necrosis factor-alpha, anti-CD40 monoclonal antibodies or tranforming growth factor-beta correlates with levels of IgE production. Int Immunol 4:397-406
59. Armitage RJ, Macduff BM, Spriggs MK, Fanslow WC (1993) Human B-cell proliferation and immunoglobulin secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J Immunol 150:3671-3680
60. Muraguchi A, Kehr] JH, Longo DL, Volkman DJ, Smith KA, Fauci AS (1985) Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. J Exp Med 161:181-197
61. Defrance T, Vanbervliet B, Aubry JP, Banchereau J (1988) Interleukin 4 inhibits the proliferation but not the differentiation of activated human B cells in response to inteleukin 2. J Exp Med 168:1321-1337
62. Jelinek DF, Lipsky PE (1987) Enhancement of human B cell proliferation and differentiation by tumor necrosis factor-alpha and interleukin 1. J Immunol 139:2970-2976
63. Kehrl JH, Miller A, Fauci AS (1987) Effect of tumor necrosis factor a on mitogen-activated human B cells. J Exp Med 166:786-791
64. Clutterbuck E, Shields JG, Gordon J, Smith SH, Boyd A, Callard RE, Campbell HD, Young IG, Sanderson CJ (1987) Recombinant human interleukin 5 is an eosinophil differentiation factor but has no activity in standard human B cell growth factor assays. Eur J Immunol 17:1743-1750
65. van Vlasselaer P, Punnonen J, de Vries JE (1992) Transforming growth factor-beta directs IgA switching in human B cells. J Immunol 148:2062-2067
66. Allen RC, Armitage RJ, Conley ME, Rosenblatt H, Jenkins NA, Copeland NG, Bedell MA, Edelhoff S, Disteche CM, Simoneaux DK, Fanslow WC, Belmont J, Spriggs MK (1993) CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259:990-993
67. Aruffo A, Farrington M, Hollenbaugh D, Li X, Milatovich A, Nonoyama S, Bajorath J, Grosmaire LS, Stenkamp R, Neubauer M, Roberts RL, Noelle RJ, Ledbetter JA, Francke U, Ochs HD (1993) The CD40 ligand, gp39, is defective in activated T cells from patients with X-Linked * hyper-IgM syndrome. Cell 72:291-300
68. Padayachee M, Feighery C, Finn A, McKeown C, Levinsky RJ, Kinnon C, Malcolm S (1992) Mapping of the X-linked form of hyper-IgM syndrome (HIGM1) to Xq26 by close linkage to HPRT. Genomics 14:551-553
69. Korthauer U, Graf D, Mages HW, Briere F, Padayachee M, Malcolm S, Ugazio AG, Notarangelo LD, Levinsky RJ, Kroczek RA (1993) Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper IgM. Nature 361:539-541
70. DiSanto JP, Bonnefoy JY, Gauchat JF, Fischer A, de Saint Basile G (1993) CD40 ligand mutations in X-linked immunodeficicncy with hyper-IgM. Nature 361:541-543
71. Le J, Vilcek J (1987) Tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities. Lab Invest 56:234-248
72. Landis RC, Friedman ML, Fisher RI, Ellis TM (1991) Induction of human monocyte IL-1 mRNA and secretion during anti-CD3 mitogenesis requires two distinct T cell-derived signals. J Immunol 146:128-135
73. Vey E, Zhang JH, Dayer JM (1992) IFNγ and l, 25(OH)2D3 induce on THP-1 cells distinct patterns of cell surface antigen expression, cytokine production, and responsiveness to contact with activated T cells. J Immunol 149:2040-2046
74. Webb DS, Shimizu Y, Van Seventer GA, Shaw S, Gerrard TL (1990) LFA-3, CD44, and CD45: Physiologic triggers of human monocyte TNF and IL-1 release. Science 249: 1295-1297
75. Galy AH, Spits H (1992) CD40 is functionally expressed on human thymic epithelial cells. J Immunol 149:775-782
76. Alderson MR, Armitage RJ, Tough TW, Strockbine L, Fanslow WC, Spriggs MK (1993) CD40 expression by human monocytes: Regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp Med 178:669-674
77. Dunlap NE, Berry AK, Gore I, Decker WD, Snyder TL, Shaw GM, Hanh BH, Tildern AB (1989) Expression of activation antigens on HTLV-I and HTLV-II cell lines, (Knapp W, Dorken B, Gilks WR, Rieber EP, Schmidt RE, Stein H, von dem Borne AEG, eds), pp 487-488. Oxford University Press, Oxford
78. Ware CF, Crowe PD, Vanarsdale TL, Andrews JL, Grayson MH, Jerzy R, Smith CA, Goodwin RG (1991) Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type 1 TNF receptor during activation of resting and effector T cells. J Immunol 147:4229-4238
79. Armitage RJ, Tough TW, Macduff BM, Fanslow WC, Spriggs MK, Ramsdell F, Alderson MR (1993) CD40 ligand is a T cell growth factor. Eur J Immunol 23:2326-2331
80. Marlin SD, Springer TA (1987) Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51:813-819
81. Linsley PS, Clark EA, Ledbetter JA (1990) T cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci USA 87:5031-5035