Design of Antineoplastic Agents on the Basis of the “2-Phenylnaphthalene-Type” Structural Pattern. 2. Synthesis and Biological Activity Studies of Benzo[A]naphtho[2,3-d]furan-6,11-dione Derivatives

Journal of Medicinal Chemistry

Volumn 36, Issue 25, 1993, Pages 4108-4112

  Cheng, C C ^a   Dong, Qing ^a   Liu, Dun Fu ^a   Luo, Yi Lin ^a   Liu, Leroy F ^b   Chen, Allan Y ^b   Yu, Chiang ^b   Savaraj, Niramol ^c   Chou, Ting Chao ^d  

^a UNIVERSITY OF KANSAS CANCER CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF MIAMI   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (DIMETHYLAMINO)ETHOXYL] 1 HYDROXYBENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; BENZOFURAN DERIVATIVE; CISPLATIN; FLUOROURACIL; MITOXANTRONE; UNCLASSIFIED DRUG; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; DRUG DESIGN; DRUG POTENCY; DRUG RESISTANCE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; LUNG SMALL CELL CANCER; MINIMUM INHIBITORY CONCENTRATION; PROMYELOCYTIC LEUKEMIA; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CARCINOMA, SMALL CELL; CISPLATIN; COMPARATIVE STUDY; DNA TOPOISOMERASES, TYPE II; FURANS; HUMAN; LEUKEMIA, PROMYELOCYTIC, ACUTE; NAPHTHOQUINONES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0027741337     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00077a016     Document Type: Article

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