Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages

Atherosclerosis

Volumn 104, Issue 1-2, 1993, Pages 19-26

  Bernini, Franco ^a   Didoni, Guido ^b   Bonfadini, Giuliana ^b   Bellosta, Stefano ^b   Fumagalli, Remo ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

3 Hydroxy 3 methylglutaryl coenzyme A; Acyl CoA; Cholesterol acyltransferase; Cholesteryl ester; HMGCoA reductase inhibitors; Macrophages

Indexed keywords

ACYL COENZYME A; CHOLESTEROL ACYLTRANSFERASE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; MEVALONIC ACID; SIMVASTATIN;

ANIMAL CELL; ARTICLE; CHOLESTEROL ESTERIFICATION; DRUG MECHANISM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEREOSPECIFICITY;

ACETYLATION; ANIMAL; ANTICHOLESTEREMIC AGENTS; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL ESTERS; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTERIFICATION; FATTY ACIDS, MONOUNSATURATED; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; LIPOPROTEINS, LDL; LOVASTATIN; MACROPHAGES, PERITONEAL; MEVALONIC ACID; MICE; MICE, INBRED BALB C; SIMVASTATIN; SUPPORT, NON-U.S. GOV'T;

EID: 0027738796     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/0021-9150(93)90172-Q     Document Type: Article

References (22)

1. Drug therapy. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia
2. Regulation of the mevalonate pathway
3. Biological effects of isoprenoids
4. Vastatins inhibit cholesterol ester accumulation in human monocyte-derived macrophages
5. Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins
6. The pathogenesis of atherosclerosis. An update review
7. Protein reagent with the Folin phenol reagent
8. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
9. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein producing massive cholesterol deposition
10. Metabolism of normal and modified lowdensity lipoproteins by macrophage cell lines of murine and human origin
11. Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase
12. HMG-CoA reductase inhibitors: an exciting development in the treatment of hyperlipoproteinemia
13. Requirement for mevalonate in cycling cells: quantitative and temporal aspects
14. Defective macromolecule biosynthesis and cell-cycle progression in a mammalial cell starved for mevalonate
15. Multivalent feedback regulation of HMG-CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth
16. The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in chinese hamster ovary cells cultured with 3-β-[2 (diethyIamino)ethoxy]land rost-5-en-17-one
17. Abnormal cholesterol metabolism in imipramine-treated fibroblasts cultures. Similarities with Niemmann-Pick disease
18. Progesterone blocks cholesterol translocation from lysosomes
19. Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral membrane secretion of newly synthesized lipids by CaCo2 cells
20. Effects of MK-733 (simvastatin), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on intestinal acylcoenzyme A: cholesterol acyltransferase activity in rabbits
21. Inhibition of acyl coenzyme A: cholesterol acyltransferase by 3hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
22. Mevinolin, a competitive inhibitor of hydroxymethylglutaryl coenzyme A reductase, suppresses enterocyte esterification of exogenous but not endogenous cholesterol