Deoxyspergualin: Mode of Action and Clinical Trials

Annals of the New York Academy of Sciences

Volumn 696, Issue 1, 1993, Pages 263-269

  SUZUKI, SEIICHI ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXYSPERGUALIN; CYCLOSPORIN; METHYLPREDNISOLONE; MIZORIBINE; PREDNISOLONE; STEROID;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; CATARACT; CELL ISOLATION; CLINICAL ARTICLE; CONFERENCE PAPER; DIABETES MELLITUS; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; GROWTH INHIBITION; HEART TRANSPLANTATION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY TRANSPLANTATION; MAINTENANCE THERAPY; MALE; MOON FACE; NONHUMAN; OBESITY; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; QUALITY OF LIFE; RAT; SPLEEN CELL; T LYMPHOCYTE;

ANIMALIA;

EID: 0027731608     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1993.tb17160.x     Document Type: Article

References (22)

1. Effect of a new immunosuppressant, 15‐deoxyspergualin, on heterotopic rat heart transplantation, in comparison with cyclosporine
2. Therapeutic effect of 15‐deoxyspergualin on acute graft rejection detected by 31P nuclear magnetic resonance spectroscopy, and its effect on rat heart transplantation
3. A new immunosuppressive agent, 15‐deoxyspergualin, in dog renal allografting
4. 15‐Deoxyspergualin as an immunosuppressive agent in dogs
5. 15‐Deoxyspergualin—a novel immunosuppressant: experimental studies and clinical trials
6. Mechanism of action of 15‐deoxyspergualin. I. Suppressive effect on the induction of alloreactive secondary cytotoxic T lymphocytes in vivo and in vitro
7. Deoxyspergualin in lethal murine graft‐versus‐host disease
8. Immunosuppressive activities of 15‐deoxyspergualin in animals
9. Immunosuppressive activities of deoxyspergualin. II. The effect on the antibody responses
10. Blastogenic responses and the release of interleukin 1 and 2 by spleen cells obtained from rat skin a allograft recipients administered with 15‐deoxyspergualin
11. 15‐Deoxyspergualin, an antiproliferative agent for human and mouse leukemia cells shows inhibitory effects on the synthetic pathway of polyamines
12. Deoxyspergualin, a potent antitumor agent: further studies on the cytobiological mode of action
13. Reversal of acute rejection episodes by deoxyspergualin (NKT‐01) in dogs receiving renal allografts
14. Prolongation of cardiac xenograft survival in hamster‐to‐rat combination by recipient treatment with deoxymethylspergualin
15. A novel rescue drug, 15‐deoxyspergualin
16. Clinical trials in renal graft rejection
17. Effect of 15‐deoxyspergualin on graft‐versus‐host disease in mice
18. Immunological unresponsiveness by deoxyspergualin in therapy in mice undergoing lethal graft‐versus‐host disease, and successful adoptive transfer of unresponsiveness
19. Prolongation of cardiac allograft survival in rats by recipient pretreatment with donor spleen cells and 15‐deoxyspergualin
20. Induction of transplantation unresponsiveness by deoxyspergualin and the role of suppressor T cells for its maintenance in heart‐allografted rats
21. Prolonged survival of cardiac allografts and xenografts in rat‐to‐rat and hamster‐to‐rat transplantation by treatment with deoxyspergualin
22. Continuous administration of methyldeoxyspergualin prolongs xenograft survival in hamster‐to‐rat cardiac transplantation