A Minimal Input–Output Configuration for a Priori Identifiability of a Compartmental Model of Leucine Metabolism

IEEE Transactions on Biomedical Engineering

Volumn 40, Issue 8, 1993, Pages 797-803

  Saccomani, Maria Pia ^a   Cobelli, Claudio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; BICARBONATE; CARBON; DEUTERIUM; LEUCINE; TRITIUM;

AMINO ACID METABOLISM; CALCULATION; COMPARTMENT MODEL; ISOTOPE LABELING; REVIEW;

BICARBONATES; HUMAN; LEUCINE; MATHEMATICS; MODELS, BIOLOGICAL; PILOT PROJECTS; SUPPORT, NON-U.S. GOV'T;

EID: 0027731457     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/10.238464     Document Type: Article

References (6)

1. E. R. Carson, C. Cobelli, and L. Finkelstein, The Mathematical Modeling of Metabolic and Endocrine Systems. New York: Wiley, 1983.
2. M. P. Saccomani and C. Cobelli, “A priori identifiability and qualitative experiment design in physiological system identification.” IEEE Control Syst. Mag., vol. 12, no. 6, pp. 18–23, 1992.
3. C. Cobelli, M. P. Saccomani. P. Tessari, G. Biolo. L. Luzi, and D. E. Matthews, “Compartmental model of leucine kinetics in humans,” Amer J. Physiol., vol. 261, pp. e539–e550, 1991.
4. D. M. Bier, “Intrinsically difficult problems: The kinetics of body proteins and amino acids in man,” Diabetes/Metabolism Rev., vol. 5. pp. 111–132. 1989.
5. C. S. Irving, W. W. Wong, R. J. Shulman. E. O. Smith, and P. D. Klein, “[13C]bicarbonate kinetics in humans: Intra-vs. inierindividual variations,” Amer. J. Physiol., vol. 245, pp. R190–R202, 1983.
6. S. Audoly and I. D'Angio. “On the identifiability of linear compartmental systems: A revisited transfer function approach based on topological properties,” Math. Biosci., vol. 66, pp. 201–228, 1983.