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Volumn 16, Issue 3, 1993, Pages 175-181

Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate

Author keywords

Anticonvulsant effect; Brain interstitial fluid; Gabapentin; Microdialysis; Pharmacokinetic; Rat

Indexed keywords

GABAPENTIN;

EID: 0027723017     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-1211(93)90078-L     Document Type: Article
Times cited : (114)

References (29)
  • 3
    • 0025343921 scopus 로고
    • Gabapentin in partial epilepsy
    • (1990) Lancet , vol.1 , pp. 1114-1117
    • Chadwick1
  • 12
    • 85071410571 scopus 로고    scopus 로고
    • McNally, W.P., DeHart, P.D., Hansen, B.J., Radulovic, L.L. and Bockbrader, H.N., Gabapentin comparative whole-body autoradiography (WBAR) studies in mouse, rat, and monkey, Pharm. Res., in press (Abstract).
  • 14
    • 0022496925 scopus 로고
    • Neutral amino acid transport at the humans blood-brain barrier
    • 3rd edn.
    • (1986) Fed. Proc. , vol.45 , pp. 2073-2078
    • Pardridge1    Choi2
  • 17
    • 0021036376 scopus 로고
    • Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: are there common or different sites of action?
    • (1983) Eur. J. Pharmacol. , vol.94 , pp. 341-344
    • Reimann1
  • 18
    • 0018412111 scopus 로고
    • Inhibition pattern by analysis indicates the presence of ten or more transport systems for amino acids in brain cells
    • (1979) J. Neurochem. , vol.32 , pp. 719-726
    • Sershen1    Lajtha2
  • 20
    • 0027402753 scopus 로고
    • A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma
    • (1993) Pharm. Res. , vol.10 , pp. 276-281
    • Stewart1    Kugler2    Thompson3    Bockbrader4
  • 22
    • 0002544304 scopus 로고
    • Experimental selection, quantification and evaluation of anticonvulsants
    • R. Levy, R. Mattson, B. Meldrum, J.K. Penry, F.E. Dreifuss, 3rd edn., Raven Press, New York, NY
    • (1989) Antiepileptic Drugs , pp. 85-102
    • Swinyard1    Woodhead2    White3    Franklin4
  • 25
    • 85071405503 scopus 로고    scopus 로고
    • 3H]Gabapentin may label a system-L like neutral amino acid carrier in brain, Eur. J. Pharmacol., in press.
  • 29
    • 0026082901 scopus 로고
    • Extracellular concentrations of amino acid transmitters in ventral hippocampus during and after development of kindling
    • (1991) Brain Res. , vol.540 , pp. 315-318
    • Zhang1    Hudson2    Sobotka3    Hong4    Tilson5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.