Synthesis of and glycosidase inhibition by α-l-homofuconojirimycin

Bioorganic and Medicinal Chemistry Letters

Volumn 3, Issue 12, 1993, Pages 2533-2536

  Andrews, D M ^a   Bird, M I ^a   Cunningham, M M ^a   Ward, P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HOMOFUCONOJIRIMYCIN; ALPHA LEVO FUCOSIDASE; ALPHA MANNOSIDASE; BETA GLUCOSIDASE; DEOXYFUCONOJIRIMYCIN; GLYCOSIDASE INHIBITOR; SIALIDASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COW; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; EPIDIDYMIS; HUMAN; HUMAN TISSUE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; STEREOCHEMISTRY;

EID: 0027714856     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)80711-3     Document Type: Article

References (8)

1. Iminoheptitols as glycosidase inhibitors: Synthesis of, and mannosidase and fucosidase inhibition by, α—homomannojirimycin and 6-epi-homomannojirimycin
2. Azasugar and glycal inhibitors of α-L-fucosidase
3. Iminoheptitols as glycosidase inhibitors: synthesis of and specific α-L-fucosidase inhibition by β-L-homofuconojirimycin and 1-β-C-substituted deoxymannojirimycins
4. Stereochemical control of reductions. 5. Effects of electron density and solvent on group haptophilicity
5. Directed Homogeneous Hydrogenation[New Synthetic Methods(65)]
6. Inhibition of alpha-L-fucosidase by derivatives of deoxyfuconojirimycin and deoxymannojirimycin.
7. Chemo-enzymatic synthesis of five-membered azasugars as inhibitors of fucosidase and fucosyltransferase: An issue regarding the stereochemistry discrimination at transition states