Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

Neuroscience Letters

Volumn 164, Issue 1-2, 1993, Pages 89-92

  MacManus, John P ^a   Buchan, Alastair M ^b   Hill, Irene E ^a   Rasquinha, Ingrid ^a   Preston, Edward ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Apoptosis; Cell death; DNA damage; Ischemia; Necrosis; Stroke

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; DNA DAMAGE; HIPPOCAMPUS; HISTOLOGY; MALE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; DNA DAMAGE; ETHIDIUM; HISTOCYTOCHEMISTRY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T;

EID: 0027714833     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(93)90864-H     Document Type: Article

References (15)

1. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
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3. Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons
4. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
5. Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis
6. Glutamate triggers internucleosomal DNA cleavage in neuronal cells
7. Failure of a protein synthesis inhibitor to modify glutamate receptor-mediated neurotoxicity in vivo
8. DNA fragmentation indicative of apoptosis in brain following ischemia
9. Glucocorticoid endangerment of hippocampal neurons does not involve deoxyribonucleic acid cleavage
10. Three openings of the blood-brain barrier produced by forebrain ischemia in the rat
11. Temporal profile of neuronal damage in a model of transient forebrain ischemia
12. Morphological, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia
13. Internucleosomal deoxyribonucleic acid cleavage activity in apoptotic thymocytes: detection and endocrine regulation
14. Gene induction by γ-irradiation leads to DNA fragmentation in lymphocytes
15. Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation