Continuous enzymatic production of oligopeptides: Synthesis of an enkephalin pentapeptide in a multistage bioreactor

Enzyme and Microbial Technology

Volumn 15, Issue 11, 1993, Pages 928-935

  Richards, Anthony O ^a   Gill, Iqbal S ^a   Vulfson, Evgeny N ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

Continuous bioreactor; enzymes in organic solvent; oligopeptide synthesis; proteinase K; chymotrypsin

Indexed keywords

BIOREACTORS; BIOSYNTHESIS; BIOTECHNOLOGY; CONDENSATION REACTIONS; ENZYMES; OLIGOMERS; SOLVENTS;

ALPHA CHYMOTRYPSIN; ENKEPHALIN PENTAPEPTIDES; ORGANIC SOLVENTS; PROTEINASE K;

POLYPEPTIDES;

CHYMOTRYPSIN A; OLIGOPEPTIDE; PROTEINASE K;

ARTICLE; BIOREACTOR; ENZYME CHEMISTRY; PEPTIDE SYNTHESIS;

AMINO ACID SEQUENCE; ENKEPHALINS; ENZYMES; FEASIBILITY STUDIES; KINETICS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES;

EID: 0027703462     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/0141-0229(93)90168-2     Document Type: Article

References (25)

1. Enzyme-catalysed synthesis of peptides containing D-amino acids
2. Developments in Industrial Microbiology
3. The Enzymatic Synthesis of Protected Valine-5 Angiotensin II Amide-1
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5. Design of Proteinase–Catalyzed Synthesis of Oligopeptides in an Aqueous–Organic Biphasic System
6. Synthesis of an aspartame precursor by immobilized thermolysin in an organic solvent
7. Facile enzymatic synthesis of N-acyl-enkephalin amides