Hydrogel delivery systems based on polymer blends, block co-polymers or interpenetrating networks

Advanced Drug Delivery Reviews

Volumn 11, Issue 1-2, 1993, Pages 109-135

  Bae, You Han ^a   Kim, Sung Wan ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Degradation; Heterogeneous hydrogel; Hydrophilic polyurethane; Interpolymer complex; Phase separation; Polymer composite; Polymer conjugate; Release kinetics; Thermoplastic hydrogel

Indexed keywords

BLOCK COPOLYMERS; COMPOSITE MATERIALS; DEGRADATION; GELS; GRAFT COPOLYMERS; INTERPENETRATING POLYMER NETWORKS; POLYMER BLENDS; POLYURETHANES; THERMOPLASTICS;

HYDROGELS; PHASE SEPARATION; POLYMER CONJUGATES; RELEASE KINETICS;

CONTROLLED DRUG DELIVERY;

2 HYDROXYETHYL METHACRYLATE; ACRYLAMIDE; ACRYLIC ACID; COPOLYMER; DIMETICONE; MACROGOL; METHACRYLAMIDE; METHACRYLIC ACID; METHACRYLIC ACID BUTYL ESTER; N ISOPROPYLACRYLAMIDE; N,N DIMETHYLACRYLAMIDE; POLY GAMMA BENZYL GLUTAMATE; POLY(ETHYLOXAZOLINE); POLY(METHYL METHACRYLATE); POLYGLACTIN; POLYLACTIC ACID; POLYLYSINE; POLYMACON; POLYMER; POLYMETHACRYLIC ACID; POLYPROPYLENE OXIDE; POLYTETRAMETHYLENE OXIDE; POLYVINYL ALCOHOL; POVIDONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINYL ALCOHOL;

BIOCOMPATIBILITY; BIODEGRADATION; COMPLEX FORMATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; HYDROGEL; PHARMACEUTICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW;

EID: 0027625506     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-409X(93)90029-4     Document Type: Review

References (114)

1. Hydrophilic gels for biological use
2. Hydrogels for Medical and Related Applications
3. Synthetic hydrogels for biomedical application
4. Solute permeation through hydrogel membranes
5. Permeation of water-soluble solutes through poly(2-hydroxyethyl methacrylate) and poly(2- hydroxyethyl methacrylate) crosslinked with ethylene glycol dimethacrylate
6. Hydrogels for controlled drug release
7. Preparation methods and structure of hydrogels
8. Permeation of water through poly(2-hydroxyethyl methacrylate) and related polymers: Temperature effects
9. Preformulation of an ARA-A transdermal delivery system: Membrane fabrication and characterization
10. Proposed method of intracordal injection and gelation of polymer solution in vocal cords: polymer consideration
11. Diffusive and hydraulic permeabilities of water swollen polymer membranes
12. Macromolecular diffusion through polymer membranes
13. Solute diffusion in swollen membrane
14. Swelling-controlled constant rate delivery systems
15. A mechanistic interpretation of swelling- controlled, constant rate delivery systems
16. Dynamically swelling hydrogels in controlled release applications
17. Phase separation in poly(ethylene glycol)/poly(lactic acid) blends
18. A study of the leaching/retention of water-soluble polymers in blends with ethylcellulose using torsional braid analysis
19. Poly(l-lactic acid)/pluronic blends: Characterization of phase separation behavior, degradation, and morphology and use as protein-releasing matrices
20. Miscibility of mixtures from partially hydrolized poly(vinyl acetate) and poly(N-vinyl-2-pyrrolidone)
21. Thermoplastic microphase separated hydrogels and their potential for controlled drug delivery
22. Multiphase materials with lignin
23. Blends of PVA and PGLA: control of the permeability and degradability of hydrogels by blending
24. Polyethylene/hydrophylic polymer blend for biomedical applications
25. Novel two-phase polymer system — An overview
26. Swelling controlled release systems: Progress toward zero-order kinetics with polymer blends
27. Silicone rubber-hydrogel composites as polymeric biomaterials
28. Silicone rubber-hydrogel composites as polymeric biomaterials
29. Insolubilization of apatite-collagen composites by UV irradiation
30. Controlled release of anticancer drugs from collagen-poly(HEMA) hydrogel matrices
31. In vivo biocompatibility of collagen-poly(HEMA) hydrogels
32. Poly(2-hydroxyethyl methacrylate)-collagen composites which promote muscle cell differentiation in vitro
33. Synthetic hydrogels
34. Poly(alkylene oxides) and polymeric poly(carboxylic acids)
35. Some factors affecting the molecular association of poly(ethylene oxide) and poly(acrylic acid) in aqueous solution
36. Interaction between macromolecules in solution and intermolecular complexes
37. Interpolymer complexes
38. Utilization of polyelectrolyte complexes in biology and medicine
39. Medical uses for polyelectrolyte complexes
40. Biomedical behavior of synthetic polyion complexes toward blood platelets
41. Permeation of water and alcohols through hydrogen-bonded interpolymer complex membrane of poly(acrylic acid) and poly(vinyl alcohol)
42. Optimization of microencapsulation parameter: Semipermeable microcapsules as a bioartificial pancreas
43. Reversal of diabetes in BB rats by tranplantation of encapsulated pancreatic islets
44. Microcapsules through polymer complexation
45. Microcapsules through polymer complexation
46. Electrically erodible polymer gel for controlled release of drugs
47. Glucose-responsive complex formation between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with pendent phenylboronic acid moiety
48. Effect of the incorporation of amino groups in a glucose-responsive polymer complex having phenylboronic acid moieties
49. A novel drug delivery system utilizing a glucose responsive polymer complex between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with a phenylboronic acid moiety
50. Thermoplastic polyurethane elastomers
51. Prednisolone release from copolyurethane monolithic devices
52. Synthesis characterization and permeation properties of polyether- based polyurethanes
53. Blood interactions with novel polyurethaneurea hydrogels
54. Drug release from monolithic devices of segmented polyether-poly(urethane-urea)s having both hydrophobic and hydrophilic soft segments
55. Novel design of microreservoir-dispersed matrices for drug delivery formulations: Regulative drug release from poly(ethylene oxide)- and poly(tetramethylene oxide)-based segmented polyurethanes
56. Polyurethane elastomer with PEO-PTMO-PEO soft segment for sustained release of drugs
57. Crosslinked poly(alkylene oxides) for the preparation of controlled release micromatrices
58. Nonaqueous drug permeation through synthetic membranes
59. Preparation and properties of d,l-lactide and ethylene oxide copolymer: A modifying biodegradable polymeric materials
60. Biodegradable PEO/PLA block copolymers
61. Synthesis and chracterization of block copolymers from d,l-lactide and poly(ethylene glycol) with stannous chloride
62. “Super microcapsule” (SMC)
63. Biodegradable PELA block copolymers: In vivo degradation and tissue reaction
64. Morphological study of biodegradable PEO/PLA block copolymers
65. Compositional and structural analysis of PELA biodegradable block copolymers degrading under in vitro condition
66. Preparation, characterization, and properties of polylactide (PLA)-poly(ethylene glycol) (PEG) copolymers: A potential drug carrier
67. Microspheres of biodegradable block copolymer for long-acting controlled delivery of contraceptives
68. Synthèse et caractérisation de copolymères séquences polyoxyéthylène/poly(ε-carprolactone)
69. Biodegradable polymers for use in surgery-poly(ethylene oxide)poly(ethylene terephthalate) (PEO/PET) copoymers
70. Biodegradable polymers for use in surgery-poly(ethylene oxide)poly(ethylene terephthalate) (PEO/PET) copolymers
71. Degradable thermoplastic hydrogels
72. Degradable polymers
73. Microspheres of poly(γ-benzyl l-glutamate)/poly(ethylene oxide) block copolymer and their biodegradability in mice
74. Synthesis and structrual study of an ABA bloack copolymer consisting of poly(-benzyl l-glutamate) as the A block and poly(ethylene oxide) as the B block
75. In vitro degradation of poly(γ-benzyl l-glutamate)/poly(ethyleneglycol) block copolymers
76. Drug release from triblock copolymers of poly(hydroxyalkyl l-glutamine/poly(ethylene oxide)/poly(hydroxyalkyl l-glutamine)
77. Synthesis and characterization of amphiphilic polyisobutylene/poly(ethylene glycol) di- and triblock copolymers
78. Drug permeability of modified silicone polymers
79. Synthesis and characterization of block copolymers: Poly(ethylene oxide-β-methacrylonitrile) and poly(ethylene oxide-β-acrylonitrile)
80. Synthesis and characterization of block copolymers of poly(ethylene oxide) and poly(methyl methacrylate)
81. Diffusion of rat atrial natriuretic factor in thermoreversible poloxamer gels
82. The effect of solute and polymers on the gelation properties of Pluronic F-127 solutions for controlled drug delivery
83. Sustained delivery of interleukin-2 from Poloxamer 407 gel matrix following intraperitoneal injection in mice
84. Synthesis and characterization of hydrogels from graft copolymers
85. Drug permeability of modified silicone polymers
86. Preparation of poly(methacrylic-γ-ethylene oxide) microspheres
87. Self-associating networks of poly(methacrylic acid-γ-ethylene glycol)
88. Controlled release by using poly(methacrylic acid-γ-ethylene glycol) hydrogels
89. Permeability of a heparin- polyvinyl alcohol to thrombin and antithrombin III
90. Water content and compression modulus of some heparin-PVA hydrogels
91. Properties of heparin-poly(vinyl alcohol) hydrogel coating
92. Poly(vinyl alcohol)-heparin hydrogels as sensor cathether membranes
93. Polymer-protein conjugates
94. Enzyme-digestible swelling hydrogels as flatforms for long-term oral drug delivery Synthesis and characterization
95. Biochemical and mechanical characterization of enzyme-digestible hydrogels
96. In vitro and in vivo studies of enzyme-digestible hydrogels for oral drug delivery
97. Insulin-albumin microbeads: An implantable, biodegradable system
98. Interaction of anitithrombin III with preadsorbed albumin-heparin conjugates
99. Albumin-heparin microspheres as carriers for cytostatic agents
100. Release of macromolecules from albumin-heparin microspheres
101. Release of proteins via ion exchange from albumin-heparin microspheres
102. Interpenetrating polymer networks
103. Heterogeneous interpenetrating polymer networks for drug delivery
104. A new thermo-sensitive hydrogel Interpenetrating polymer networks from N-acryloyl pyrrolidine and poly(oxyethylene)
105. Thermoresponsive swelling and drug release switching of interpenetrating polymer networks composed of poly(acrylamide-co-butylmethacrylate) and poly(acrylic acid)
106. Complex-forming poly(oxyethylene)/ poly(acrylic acid) interpenetrating polymer networks
107. Complex-forming poly(oxyethylene)/ poly(acrylic acid) interpenetrating polymer networks
108. “On-off” thermocontrol of solute transport
109. “On-off” thermocontrol of solute transport
110. Gradient-IPN-modified beads Their sensitivity by diffusion-polycondensation and function as controlled drug delivery agents