Fractional Factorial Study of Hybridoma Behavior. 2. Kinetics of Nutrient Uptake and Waste Production

Biotechnology Progress

Volumn 9, Issue 3, 1993, Pages 309-316

  Gaertner, John G ^a   Dhurjati, Prasad ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM DERIVATIVE; GLUCOSE; GLUTAMINE; LACTIC ACID; LACTIC ACID DERIVATIVE;

ARTICLE; BIOSYNTHESIS; CELL DIVISION; CELL LINE; CULTURE MEDIUM; FACTORIAL ANALYSIS; HYBRIDOMA; KINETICS; METABOLISM;

AMMONIUM COMPOUNDS; CELL DIVISION; CELL LINE; CULTURE MEDIA; FACTOR ANALYSIS, STATISTICAL; GLUCOSE; GLUTAMINE; HYBRIDOMAS; KINETICS; LACTATES; LACTIC ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.;

GLUCOSE; GROWTH KINETICS; MATHEMATICAL MODELS; METABOLISM;

FRACTIONAL FACTORIAL STUDY; HYBRIDOMA; NUTRIENT UPTAKE; WASTE PRODUCTION;

CELL CULTURE;

EID: 0027596218     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1021/bp00021a010     Document Type: Article

References (26)

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7. Simultaneous Measurements of Oxygen Diffusion Coefficients and Solubilities in Fermentation Media with Polarographic Oxygen Electrodes
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11. Effect of Ammonium Ion and Extracellular pH on Hybridoma Cell Metabolism and Antibody Production
12. Mathematical Modeling of the Effects of Ammonium Ion on the Intracellular pH of Hybridoma Cells
13. Effects of Dissolved Oxygen Concentration on Hybridoma Growth and Metabolism in Continuous Culture
14. Transient Responses of Hybridoma Cells to Nutrient Additions in Continuous Culture: I. Glucose Pulse and Step Changes
15. The Transient Responses of Hybridoma Cells to Nutrient Additions in Continuous Culture: II. Glutamine Pulse and Step Changes
16. Chemical Decomposition of Glutamine in Cell Culture Media: Effect of Media Type, pH, and Serum Concentration
17. Monoclonal Antibody Against Human Fibronectin Which Inhibits Cell Attachment
18. NADH Fluorescence and Oxygen Uptake Responses of Hybridoma Cultures to Substrate Pulse and Step Changes
19. Effects of Cell Density and Glucose and Glutamine Levels on the Respiration Rates of Hybridoma Cells
20. Reciprocal Regulation of Glucose and Glutamine Utilization by Cultured Human Diploid Fibroblasts