-
1
-
-
0026696360
-
Mitogen-activated Protein Kinases: Versatile Transducers for Cell Signaling
-
of special interest, Review of the MAP kinase family members, their activation and regulatory roles.
-
(1992)
Trends Biochem Sci
, vol.17
, pp. 233-238
-
-
Pelech1
Sanghera2
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2
-
-
0026585231
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MAP Kinase by Any Other Name Smells Just as Sweet
-
(1992)
Cell
, vol.68
, pp. 3-6
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-
Thomas1
-
6
-
-
0026523559
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ras Mediates Nerve growth Factor Receptor Modulation of Three Signal-transducing Protein Kinases: MAP Kinase, Raf-1 and RSK
-
(1992)
Cell
, vol.68
, pp. 1041-1050
-
-
Wood1
Sarnecki2
Roberts3
Blenis4
-
8
-
-
0026541205
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Requirements for Phosphorylation of MAP Kinase During Meiosis in Xenopus Oocytes
-
(1992)
Science
, vol.255
, pp. 212-215
-
-
Posada1
Cooper2
-
9
-
-
0027014912
-
The MAP Kinase Activator
-
of special interest, Reviews the MAP kinase activator, its purification from different organisms its characterization, its regulation by phosphorylation, and its structural relationship to the STE7 family of protein kinases.
-
(1992)
Curr Opin Cell Biol
, vol.4
, pp. 992-999
-
-
Ahn1
Seger2
Krebs3
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11
-
-
0026509971
-
MAP Kinase Activator from Insulin-stimulated Skeletal Muscle Is a Protein Threonine/Tyrosine Kinase
-
(1992)
EMBO J
, vol.11
, pp. 2123-2129
-
-
Nakielny1
Cohen2
Wu3
Sturgill4
-
13
-
-
0026743949
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Purification of a Murine Protein Tyrosine/Threonine Kinase that Phosphorylates Activates the ERK-1 Gene Product: Relationship to the Fission Yeast byr1 Gene Product
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 8205-8209
-
-
Crews1
Erikson2
-
15
-
-
0026728568
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Kinase Kinase from Rabbit Skeletal Muscle. A Novel Dual Specificity Enzyme Showing Homology to Yeast Protein Kinases Involved in Pheromone-dependent Signal Transduction
-
(1992)
FEBS Lett
, vol.308
, pp. 183-189
-
-
Nakielny1
Campbell2
Cohen3
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16
-
-
0025875819
-
Dissection of the Protein Kinase Cascade by which Nerve Growth Factor Activates MAP Kinases
-
(1991)
Nature
, vol.353
, pp. 170-173
-
-
Gomez1
Cohen2
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21
-
-
0025885772
-
Signal Transduction During Pheromone Response in Yeast
-
of special interest, Reviews the major events of signal transduction from the receptor to targets regulating transcriptional and cell cycle responses to pheromone.
-
(1991)
Annu Rev Cell Biol
, vol.7
, pp. 699-728
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-
Marsh1
Neiman2
Herskowitz3
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22
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0025992278
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Signal Transduction in Yeast Mating: Receptors, Transcription Factors, and the Kinase Connection
-
of special interest, Reviews the major events of signal transduction from the receptor to targets regulating transcriptional and cell cycle responses to pheromone.
-
(1991)
Trends Genet
, vol.7
, pp. 393-398
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-
Sprague1
-
24
-
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0025225363
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STE11 Is a Protein Kinase Required for Cell-type-specific Transcription and Signal Transduction in Yeast
-
(1990)
Genes Dev
, vol.4
, pp. 1862-1874
-
-
Rhodes1
Connell2
Errede3
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25
-
-
0024442034
-
A Putative Protein Kinase Overcomes Pheromone-induced Arrest of Cell Cycling in S. cerevisiae
-
(1989)
Cell
, vol.58
, pp. 1107-1119
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-
Courchesne1
Kunisawa2
Thorner3
-
26
-
-
0025101239
-
FUS3 Encodes a cdc2 +/ CDC28-related Kinase Required for the Transition from Mitosis into Conjugation
-
(1990)
Cell
, vol.60
, pp. 649-664
-
-
Elion1
Grisafi2
Fink3
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28
-
-
0025254301
-
Overproduction of the Yeast STE12 Protein Leads to Constitutive Transcriptional Induction
-
(1990)
Genes Dev
, vol.4
, pp. 492-502
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-
Dolan1
Fields2
-
29
-
-
0025998311
-
FUS3 Represses CLN1 and CLN2 and in Concert with KSS1 Promotes Signal Transduction
-
β-subunit but before the STE12 transcription factor.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 9392-9396
-
-
Elion1
Brill2
Fink3
-
30
-
-
0027048684
-
The Protein Kinase Homologue STE20p Is Required to Link the Yeast Pheromone Response G-protein Sub-units to Downstream Signalling Components
-
of outstanding interest, Describes the cloning, phenotype and sequence of STE20. Presents epistasis analyses showing that STE20 functions after, or at the same level, as the G protein but before the STE5 protein and the STE11 kinase.
-
(1992)
EMBO J
, vol.11
, pp. 4815-4824
-
-
Leberer1
Dignard2
Harcus3
Thomas4
Whiteway5
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31
-
-
0021873142
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Molecular Cloning and Characterization of the STE7 and STE11 Genes of Saccharomyces cerevisiae
-
(1985)
Mol Cell Biol
, vol.5
, pp. 1878-1886
-
-
Chaleff1
Tatchell2
-
32
-
-
0026725796
-
Signal Transduction in Saccharomyces cerevisiae Requires Tyrosine and Threonine Phosphorylation of FUS3 and KSS1
-
of outstanding interest, Presents evidence that the pheromone-induced signal causes FUS3 to be phosphorylated on Thr180 and Tyr182. A mutation introduced at either position results in complete loss of function in vivo. The phosphorylation events are not autocatalytic but depend on functions provided by STE7 and STE11 kinases.
-
(1992)
Genes Dev
, vol.6
, pp. 1280-1292
-
-
Gartner1
Nasmyth2
Ammerer3
-
33
-
-
0027476416
-
MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro.
-
of outstanding interest, in press, Presents evidence from in vitro phosphorylation assays and reconstitution experiments that STE7 is the FUS3 activator. STE7 is a dual specificity kinase that directly phosphorylates FUS3 on the appropriate threonine and tyrosine residues. The STE7 modification of FUS3 stimulates the ability of FUS3 to phosphorylate FAR1 and STE7.
-
(1993)
Nature
-
-
Errede1
Gartner2
Zhou3
Nasmyth4
Ammerer5
-
34
-
-
0026774153
-
Constitutive Mutants of the Protein Kinase STE11 Activate the Yeast Pheromone Response Pathway in the Absence of the G Protein
-
of outstanding interest, Describes alleles of STE11 that cause a constitutive pheromone response consistent with them encoding hyperactive or unregulated forms of the kinase. This paper includes epistasis analyses that place STE11 on the pathway before STE7 and FUS3/KSS1. Additional evidence shows that the hyperactive STE11 causes phosphorylation of STE7 in the absence of added pheromone.
-
(1992)
Genes Dev
, vol.6
, pp. 1293-1304
-
-
Stevenson1
Rhodes2
Errede3
Sprague4
-
35
-
-
0026661615
-
Order of Action of Components in the Yeast Pheromone Response Pathway Revealed with a Dominant Allele of the STE11 Kinase and the Multiple Phosphorylation of the STE7 Kinase
-
(1992)
Genes Dev
, vol.6
, pp. 1305-1318
-
-
Cairns1
Ramer2
Kornberg3
-
36
-
-
0027499591
-
Pheromone Induced Signal Transduction in S. cerevisiae Requires the Sequential Function of Three Protein Kinases
-
of outstanding interest, in press, Shows that pheromone induces hyperphosphorylation of STE7 on serine and threonine residues. Because a catalytically inactive form of STE7 is still modified in response to pheromone, the modifications are not due to intramolecular autocatalysis. Because STE7 activity is induced under conditions where it is not hyperphosphorylated, the modifications are a consequence of its activation, but not the determining event.
-
(1993)
Mol Cell Biol
-
-
Zhou1
Gartner2
Cade3
Ammerer4
Errede5
-
37
-
-
0027078396
-
Phosphorylation of FAR1 in Response to α-Factor: A Possible Requirement for Cell-cycle Arrest
-
of special interest, shows that transcriptional induction of FAR1 from a heterologous promoter is not sufficient for it to inhibit CLN2. Presents data showing that FAR1 is phosphorylated in response to pheromone. It is proposed that this phosphorylation may be required for FAR1 activity.
-
(1992)
Mol Biol Cell
, vol.3
, pp. 445-450
-
-
Chang1
Herskowitz2
-
39
-
-
0026587548
-
Mating Pheromones of the Fission Yeast Schizosaccaromyces pombe. Purification and Structural Characterization of M-factor and Isolation and Analysis of Two Genes Encoding the Pheromone
-
(1992)
EMBO J
, vol.11
, pp. 951-960
-
-
Davey1
-
40
-
-
0025943077
-
The Schizosaccharomyces pombe mam2 Gene Encodes a Putative Pheromone Receptor which has a Significant Homology with the Saccharomyces cerevisiae STE2 Protein
-
(1991)
EMBO J
, vol.10
, pp. 3743-3751
-
-
Kitamura1
Shimoda2
-
43
-
-
0025806672
-
byr2, a Schizosaccharomyces pombe Gene Encoding a Protein Kinase Capable of Partial Suppression of the ras1 Mutant Phenotype
-
(1991)
Mol Cell Biol
, vol.11
, pp. 3554-3563
-
-
Wang1
Xu2
Riggs3
Rodgers4
Wigler5
-
45
-
-
0023991154
-
A Gene which Encodes a Predicted Protein Kinase Can Restore Some Functions of the ras Gene in Fission Yeast
-
(1988)
EMBO J
, vol.7
, pp. 985-993
-
-
Nadin-Davis1
Nasim2
-
46
-
-
0025977196
-
Fission Yeast Genes that Confer Resistance to Staurosporine Encode an Ap-1-like Transcription Factor and a Protein Kinase Related to the Mammalian ERK1/MAP2 and Budding Yeast FUS3 and KSS1 Kinases
-
(1991)
Genes Dev
, vol.5
, pp. 60-73
-
-
Toda1
Shimanuki2
Yanagida3
-
49
-
-
0026562547
-
The ras1 Function of Schizosaccharomyces pombe Mediates Pheromone-induced Transcription
-
of special interest, Shows that activation of the RAS1 protein is not sufficient to activate the mating response pathway. Activation still requires nutritional cues and pheromone induction.
-
(1992)
EMBO J
, vol.11
, pp. 1391-1395
-
-
Nielsen1
Davey2
Egel3
-
52
-
-
0026511056
-
Mutants in the S. cerevisiae PKC1 Gene Display a Cell Cycle-specific Osmotic Stability Defect
-
of special interest, Demonstrates that pkc1 mutants undergo cell lysis. Mutant cells proliferate in osmotically stabilized medium.
-
(1992)
J Cell Biol
, vol.116
, pp. 1221-1229
-
-
Levin1
Bartlett-Heubusch2
-
54
-
-
0026584373
-
Dominant Mutations in a Gene Encoding a Putative Protein Kinase (BCK1) Bypass the Requirement for a Saccharomyces cerevisiae Protein Kinase C
-
of outstanding interest, Describes the isolation and sequence of the BCK1 gene, whose mutational activation suppresses the loss of PKC1 function. Deletion of BCK1 results in a temperature-dependent cell lysis defect.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 172-182
-
-
Lee1
Levin2
-
55
-
-
0027192944
-
MKK1 and MKK2, encoding Saccharomyces cerevisiae MAP Kinase-kinase Homologs, Function in the Pathway Mediated by Protein Kinase C
-
of outstanding interest, in press, Describes the isolation of the MKK1/2 genes, whose deletion results in temperature-dependent cell lysis. Demonstrates that overexpression of MKK1 suppresses loss of BCK1.
-
(1993)
Mol Cell Biol
-
-
Irie1
Takase2
Lee3
Levin4
Araki5
Matsumoto6
Oshima7
-
56
-
-
0027266933
-
A Yeast MAP Kinase Homolog (MPK1) Mediates Signalling by Protein Kinase C
-
of outstanding interest, in press, Describes the isolation of the MPK1 gene, whose overexpression suppresses the loss of BCK1 function. Deletion of MPK1 results in temperature-dependent cell lysis, which is complemented by Xenopus MAP kinase.
-
(1993)
Mol Cell Biol
-
-
Lee1
Irie2
Gotoh3
Watanabe4
Nishida5
Matsumoto6
Levin7
-
57
-
-
0027531645
-
An osmosensing signal transduction pathway in yeast.
-
of outstanding interest, in press, Describes the isolation of mutants in HOG1 and PBS2 using a genetic screen for osmotic sensitivity. Demonstrates PBS2-dependent tyrosine phosphorylation of the MAP kinase homolog, HOG1.
-
(1993)
Science
-
-
Brewster1
de Valoir2
Dwyer3
Winter4
Gustin5
-
58
-
-
0023387939
-
Complete Nucleotide Sequence of a Gene Conferring Polymyxin B Resistance on Yeast: Similarity of the Predicted Polypeptide to Protein Kinases
-
Proc Natl Acad Sci USA
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 5848-5852
-
-
Boguslawski1
Polazzi2
-
59
-
-
84911248655
-
A Pair of Putative Protein Kinase Genes ( YPK1 and YPK2) is Required for Cell Growth in Saccharomyces cerevisiae
-
in press
-
(1992)
Mol Gen Genet
-
-
Chen1
Lee2
Levin3
-
60
-
-
0027463637
-
cDNa Cloning of MAP Kinase Kinase Reveals Kinase Cascade Pathways in Yeast to Vertebrates
-
(1993)
EMBO J
, vol.12
, pp. 787-794
-
-
Kosako1
Nishida2
Gotoh3
-
64
-
-
0023885305
-
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
-
(1988)
Science
, vol.241
, pp. 42-52
-
-
Hanks1
Quinn2
Hunter3
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