Preparation, Characterization, and in Vivo Biodistribution Properties of Synthetically Cross-Linked Multivalent Antitumor Antibody Fragments

Bioconjugate Chemistry

Volumn 4, Issue 2, 1993, Pages 153-165

  Schott, Margaret E ^a   Frazier, Kevin A ^a   Pollock, Douglas K ^a   Verbanact, Kathryn M ^b  

^a DOW CHEMICAL COMPANY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER ANTIBODY; CROSS LINKING REAGENT; CROSS LINKING REAGENTS; DISULFIDE; EDETIC ACID; FLUORESCEIN; FLUORESCEIN DERIVATIVE; GLYCOPROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FRAGMENT; MONOCLONAL ANTIBODY; TUMOR ANTIGEN; TUMOR ASSOCIATED ANTIGEN 72; TUMOR-ASSOCIATED ANTIGEN 72;

ANIMAL; ARTICLE; CHEMISTRY; IMMUNOLOGY; KIDNEY; LIVER; MACROMOLECULE; METABOLISM; MOUSE; MOUSE STRAIN; NUDE MOUSE; TISSUE DISTRIBUTION;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; CROSS-LINKING REAGENTS; DISULFIDES; EDETIC ACID; FLUORESCEIN; FLUORESCEINS; GLYCOPROTEINS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULINS, FAB; KIDNEY; LIVER; MACROMOLECULAR SYSTEMS; MICE; MICE, INBRED BALB C; MICE, NUDE; TISSUE DISTRIBUTION;

EID: 0027572697     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc00020a008     Document Type: Article

References (47)

1. Brennan, M., Davison, P. F., and Paulus, H. (1985) Preparation of bispecific antibodies by chemical recombination of monoclonal immunoglobulin G1 fragments. Science 229, 81
2. Carrasquillo, J. A., Krohn, K. A., Beaumier, P., McGuffin, R. W., Brown, J. P., Hellstrom, K. E., Hellstrom, I., and Larson, S. M. (1984) Diagnosis of and therapy for solid tumors with radiolabeled antibodies and immune fragments. Cancer Treat. Rep. 68, 317
3. Christensen, E. I., Rennke, H. G., and Carone, F. A. (1983) Renal tubular uptake of protein: effect of molecular charge. Renal Fluid Electrolyte Physiol. 13, F436
4. Clegg, J. A., Hudecz, G., Pimm, M. V., Szekerke, M., and Baldwin, R. W. (1990) Carrier design: biodistribution of branched polypeptides with a poly(L-lysine) backbone. Bioconjugate Chem. 1, 425
5. Colcher, D., Filomena, M. F., Roselli, M., Muraro, R., Simpson-Milenic, D., and Schlom, J. (1988) Radioimmunolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies. Cancer Res. 48, 4597
6. Cumber, A. J., Ward, S. E., Winter, G., Parnell, G. D., and Warwrzynczak, E. J. (1992) Comparative stabilities in vitro and in vivo of a recombinant mouse antibody FvCys fragment and a bisFvCys conjugate. J. Immunol. 149, 120
7. Demignot, S., Pimm, M. V., and Baldwin, R. W. (1990) Comparison of biodistribution of 791T/36 monoclonal antibody and its Fab/c fragment in balb/c mice and nude mice bearing human tumor xenographs. Cancer Res. 50, 2936
8. Ellman, G. (1959) Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70
9. Feinstein, A., and Stott, D. I. (1972) An electrofocusing technique for the analysis of thiol proteins applied to a mixture of intracellular plasmacytoma proteins. J. Physiol. 226, 34
10. French, R. R., Courtenay, A. E., Ingamells, S., Stevenson, G. T., and Glennie, M. J. (1991) Cooperative mixtures of bispecific F(ab’)2 antibodies for delivering saporin to lymphoma in vitro and in vivo. Cancer Res. 51, 2353
11. Fujimori, K., Covell, D. G., Fletcher, J. E., and Weinstein, J. N. (1989) A modeling analysis of monoclonal antibody percolation through solid tumors. J. Nucl. Med. 30, 903
12. Glennie, M. J., McBride, H. M., Worth, A. T., and Stevenson, G. T. (1987) Preparation and performance of bispecific F(ab’)2 antibody containing thioether linked Fab’ fragments. J. Immunol. 139, 2367
13. Goding, J. W. (1986) Fragmentation of monoclonal antibodies. In Monoclonal antibodies: Principles and practice, 2nd ed., Section 4.5, Academic Press, New York
14. Goldberg, M., Knudsen, K. L., Platt, D., Kohen, F., Bayer, E. F., and Wilchek, M. (1991) Specific interchain crosslinking of antibodies using bismaleimides. Repression of ligand leakage in immunoaffinity chromatography. Bioconjugate Chem. 2, 275
15. Goodwin, D. A., Meares, C. F., McCall, M. J., McTigue, M., and Chaovapong, W. (1988) Pre-targeted immunoscintigraphy with indium-III-labeled bifunctional haptens. J. Nucl. Med. 29, 226
16. Hiratsuka, T. (1988) crosslinking of three heavy-chain domains of myosin adenosinetriphosphatase with a trifunctional alkylating agent. Biochemistry 27, 4110
17. Johnson, V. G., Schlom, J., Paterson, A. J., Bennett, J., Magnani, J. L., and Colcher, D. (1986) Analysis of a human tumorassociated glycoprotein (TAG-72) identified by monoclonal antibody B72.3. Cancer Res. 46, 850
18. Koppel, G. A. (1990) Recent advances with monoclonal antibody drug targeting for the treatment of human cancer. Bioconjugate Chem. 1, 13
19. Kruper, W. J., Jr., Pollock, D. K., Fordyce, W. A., Fazio, M. J., and Inbasekaran, M. N. (1988) Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation. Eur. Pat. Appl. No. 88109799.2
20. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227, 680
21. Liberatore, F. A., Comeau, R. D., McKearin, J. M., Pearson, D. A., Belonga, B. Q., III, Brocchini, S. J., Kath, J., Phillips, T., Oswell, K., and Lawton, R. G. (1990) Site-directed chemical modification and crosslinking of a monoclonal antibody using equilibrium transfer alkylating cross-link reagents. Bioconjugate Chem. 1, 36 (and accompanying paper)
22. Maack, T., Johnson, V., Kau, S. T., Figueiredo, J., and Sigulem, D. (1979) Renal filtration, transport, and metabolism of lowmolecular weight proteins: A review. Kidney Int. 167, 251
23. Mandy, W. J., and Nisonoff, A. (1963) Effect of reduction of several disulfide bonds on the properties and recombination of univalent fragments of rabbit antibody. J. Biol. Chem. 238, 206
24. Means, G. E., and Feeney, R. E. (1990) Chemical modification of proteins: History and applications. Bioconjugate Chem. 1, 2
25. Meares, C. F., McCall, M. J., Reardan, D. T., Goodwin, D. A., Diamanti, C. I., and McTigue, M. (1984) Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions. Anal. Biochem. 142, 68
26. Meares, C. F., McCall, M. J., Deshpande, S. V., DeNardo, S. J., and Goodwin, D. A. (1988) Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver. Int. J. Cancer Suppl. 2, 99
27. Milenic, D. E., Yokota, T., Filpula, D. R., Finkelman, M. A. J., Dodd, S. W., Wood, J. F., Whitlow, M., Snoy, P., and Schlom, J. (1991) Construction, binding properties, metabolism, and tumor targeting of a single chain Fv derived from the pancarcinoma monoclonal antibody CC49. Cancer Res. 51, 6363
28. Muraro, R., Kuroki, M., Wunderlich, D., Poole, D. J., Colcher, D., Thor, A., Greiner, J. W., Simpson, J. F., Molinolo, A., Noguchi, P., and Schlom, J. (1988) Generation and characterization of B72.3 second generation (CC) monoclonal antibodies reactive with the TAG-72 antigen. J. Cancer Res. 48, 4588
29. Nisonoff, A., and Rivers, M. M. (1961) Recombination of amixture of univalent antibody fragments of different specificity. Arch. Biochem. Biophys. Acta 93, 460
30. Packard, B., and Edidin, M. (1986) Site-directed labeling of a monoclonal antibody: Targeting to a disulfide bond. Biochemistry 25, 3548
31. Perez, P. R., Hoffman, W., Shaw, S., Bluestone, J. A., and Segal, D. M. (1985) Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody. Nature 316, 354
32. Quadri, S. M., Lai, J., Vriesendorp, H. M., and Williams, J. R. (1992) Evaluation of stabilized F(ab’) 2 fragments of monoclonal antiferritin antibody in nude mouse model. Antibody Immunoconjugate Radiopharm. 5, 125 (abstract)
33. Riddles, P. W., Blakeley, R. C., and Zerner, B. (1979) Ellman′s reagent: 5,5′-Dithiobis(2-nitrobenzoic acid)—A reexamination. Anal. Biochem. 94, 75
34. Segal, D. M., and Wunderlich, J. R. (1988) Targeting of cytotoxic cells with heterocrosslinked antibodies. Cancer Invest. 6, 83
35. Sharkey, R. M., Motta-Hennessy, C., Pawlyk, D., Siegel, J. A., and Goldenberg, D. M. (1990) Biodistribution and radiation dose estimates for yttrium-and iodine-labeled monoclonal antibody IgG and fragments in nude mice bearing human colonic tumor xenografts. Cancer Res. 50, 2330
36. Smyth, D. G., Nagamatsu, A., and Fruton, J. S. (1960) Some reactions of N-ethylmaleimide. J. Am. Chem. Soc. 82, 4600
37. Staerz, U. D., and Bevan, M. J. (1986) Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity. Proc. Natl. Acad. Sci. U.S.A. 83, 1453
38. Stevenson, G. T., Glennie, M. J., Paul, F. E., Stevenson, F. K., Watts, H. F., and Wyeth, P. (1985) Preparation and properties of FablgG, a chimeric univalent antibody designed to attack tumour cells. Biosci. Rep. 119, 991
39. Stevenson, G. T., Pindar, A., and Slade, C. J. (1989) A chimeric antibody with dual Fc regions (bisFabFc) prepared by manipulations at the IgG hinge. Anti-Cancer Drug Des. 3, 219
40. Stickney, D. R., Frincke, J. M., Slater, J. B., Ahlem, C. N., Merchant, B., and Slater, J. M. (1988) Bifunctional antibody technology: Clinical applications for CEA expressing tumors. Third International Conference on Monoclonal Antibody Immunoconjugates for Cancer, Feb. 4-6 (San Diego)
41. Strober, W., and Waldmann, T. A. (1974) The role of the kidney in the metabolism of plasma proteins. Nephron 13, 35
42. Sumpio, B. E. (1981) Tubular absorption and catabolism of low molecular weight proteins. Ph.D. Dissertation
43. Takakura, Y., Fujita, T., Hashide, M., and Sezaki, H. (1990) Disposition characteristics of macromolecules in tumor-bearing mice. Pharm. Res. 7, 339
44. Volkert, W. A., Goeckeler, W. F., Ehrhardt, G. J., and Ketring, A. R. (1991) Therapeutic radionuclides: Production and decay property considerations. J. Nuc. Med. 32, 174
45. Waldmann, T. A. (1991) Monoclonal antibodies in diagnosis and therapy. Science 252, 1657
46. Waldmann, T. A., and Strober, W. (1969) Metabolism of immunoglobulins. Prog. Allergy 13, 1
47. Yokota, T., Milenic, D. E., Whitlow, M., and Schlom, J. (1992) Rapid tumor penetrance of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res. 52, 3402