CoMFA validation of the superposition of six classes of compounds which block GABA receptors non-competitively

Journal of Computer-Aided Molecular Design

Volumn 7, Issue 1, 1993, Pages 45-60

  Calder, Julie A ^a   Wyatt, John A ^a   Frenkel, David A ^a   Casida, John E ^b  

^a Roussel Uclaf Environmental Health ^*  (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Electrostatic alignment; Insecticidal activity; Picrotoxinin; Steric alignment

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; INSECTICIDE; MEMBRANE PROTEIN; PICROTOXIN; RECEPTORS, GABA A;

ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CHLORIDE CHANNEL; CLASSIFICATION; COMPUTER PROGRAM; ELECTROCHEMISTRY; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC SITE; ANIMAL; CHLORIDE CHANNELS; ELECTROCHEMISTRY; IN VITRO; INSECTICIDES; MEMBRANE PROTEINS; MODELS, MOLECULAR; PICROTOXIN; RECEPTORS, GABA-A; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027551098     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/BF00141574     Document Type: Article

References (11)

1. Optimization of parameters for semiempirical methods I. Method
2. Crossvalidation, Bootstrapping, and Partial Least Squares Compared with Multiple Regression in Conventional QSAR Studies