-
1
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
Juliano RL, Ling V (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455:152-162
-
(1976)
Biochim Biophys Acta
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
2
-
-
0024279163
-
The multidrug transporter: A double-edged sword
-
Gottesman MM, Pastan I (1988) The multidrug transporter: A double-edged sword. J Biol Chem 263: 12163-12166
-
(1988)
J Biol Chem
, vol.263
, pp. 12163-12166
-
-
Gottesman, M.M.1
Pastan, I.2
-
3
-
-
0026073186
-
Genetic mechanisms of drug resistance
-
Borst P (1991) Genetic mechanisms of drug resistance. Acta Oncol 30:87-105
-
(1991)
Acta Oncol
, vol.30
, pp. 87-105
-
-
Borst, P.1
-
4
-
-
0014290206
-
Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response
-
Kessel D, Botterill V, Wodinsky I (1968) Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response. Cancer Res 28:938-941
-
(1968)
Cancer Res
, vol.28
, pp. 938-941
-
-
Kessel, D.1
Botterill, V.2
Wodinsky, I.3
-
5
-
-
0014767029
-
Cellular resistance to actinomycin D in Chinese hamster cells in vitro’, cross-resistance, radioautographic, and cytogenetic studies
-
Biedler JL, Riehm H (1970) Cellular resistance to actinomycin D in Chinese hamster cells in vitro’, cross-resistance, radioautographic, and cytogenetic studies. Cancer Res 30:1174-1184
-
(1970)
Cancer Res
, vol.30
, pp. 1174-1184
-
-
Biedler, J.L.1
Riehm, H.2
-
7
-
-
0024329881
-
The biochemistry of P-glycoprotein-mediated multidrug resistance
-
Endicott JA, Ling V (1989) The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58:137-171
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 137-171
-
-
Endicott, J.A.1
Ling, V.2
-
8
-
-
0026210867
-
Multidrug resistance mediated by P-glycoproteins
-
Schinkel AH, Borst P (1991) Multidrug resistance mediated by P-glycoproteins. Semin Cancer Biol 2:213-226
-
(1991)
Semin Cancer Biol
, vol.2
, pp. 213-226
-
-
Schinkel, A.H.1
Borst, P.2
-
9
-
-
0001575039
-
-
(Pretlow G, Pretlow P, eds), Academic Press, San Diego
-
Gottesman MM, Schoenlein PV, Currier SJ, Bruggemann EP, Pastan I (1991) Biochemical basis for multidrug resistance in cancer in Biochemical and Molecular Aspects of Selected Cancers, Vol. 1 (Pretlow G, Pretlow P, eds), pp 339-371. Academic Press, San Diego
-
(1991)
Biochemical Basis for Multidrug Resistance in Cancer in Biochemical and Molecular Aspects of Selected Cancers
, vol.1
, pp. 339-371
-
-
Gottesman, M.M.1
Schoenlein, P.V.2
Currier, S.J.3
Bruggemann, E.P.4
Pastan, I.5
-
10
-
-
0025946645
-
Cloning and characterization of a member of the rat multidrug resistance (Mdr) gene family
-
Silverman JA, Raunio H, Gant TW, Thorgeirsson SS (1991) Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family. Gene 106: 229-236
-
(1991)
Gene
, vol.106
, pp. 229-236
-
-
Silverman, J.A.1
Raunio, H.2
Gant, T.W.3
Thorgeirsson, S.S.4
-
11
-
-
0026561813
-
Identification of distinct P-glycoprotein gene sequences in rat
-
Deuchars KL, Duthie M, Ling V (1992) Identification of distinct P-glycoprotein gene sequences in rat. Biochim Biophys Acta 1130:157-165
-
(1992)
Biochim Biophys Acta
, vol.1130
, pp. 157-165
-
-
Deuchars, K.L.1
Duthie, M.2
Ling, V.3
-
12
-
-
0025834782
-
Isolation and characterization of Drosophila multidrug resistance gene homologs
-
Wu C-T, Budding M, Griffm MS, Croop JM (1991) Isolation and characterization of Drosophila multidrug resistance gene homologs. Mol Cell Biol 11:3940-3948
-
(1991)
Mol Cell Biol
, vol.11
, pp. 3940-3948
-
-
Wu, C.-T.1
Budding, M.2
Griffm, M.S.3
Croop, J.M.4
-
13
-
-
0026672709
-
Structure of an mdr-like gene from Arabidopsis thaliana: Evolutionary implications
-
Dudler R, Hertig C (1992) Structure of an mdr-like gene from Arabidopsis thaliana: Evolutionary implications. J Biol Chem 267:5882-5888
-
(1992)
J Biol Chem
, vol.267
, pp. 5882-5888
-
-
Dudler, R.1
Hertig, C.2
-
14
-
-
0026592580
-
Expression of P-glycoprotein gene in marine sponges—identification and characterization of the 125 kD drug binding glycoprotein
-
Kurelec B, Krca S, Pivcevic B, Ugarkovic D, Bachmann M, Imsiecke G, Miiller WEG (1992) Expression of P-glycoprotein gene in marine sponges—identification and characterization of the 125 kD drug binding glycoprotein. Carcinogenesis 13:69-76
-
(1992)
Carcinogenesis
, vol.13
, pp. 69-76
-
-
Kurelec, B.1
Krca, S.2
Pivcevic, B.3
Ugarkovic, D.4
Bachmann, M.5
Imsiecke, G.6
Miiller, W.7
-
15
-
-
0026720137
-
Multidrug resistance in Leishmania donouani is conferred by amplification of a gene homologous to the mammalian mdr-1 Gene
-
Henderson DM, Sifri CD, Rodgers M, Wirth DF, Hendrickson N, Ullman B (1992) Multidrug resistance in Leishmania donouani is conferred by amplification of a gene homologous to the mammalian mdr-1 Gene. Mol Cell Biol 12:2855-2865
-
(1992)
Mol Cell Biol
, vol.12
, pp. 2855-2865
-
-
Henderson, D.M.1
Sifri, C.D.2
Rodgers, M.3
Wirth, D.F.4
Hendrickson, N.5
Ullman, B.6
-
16
-
-
0026729323
-
A gene associated with cell division and drug resistance in Giardia duodenalis
-
Upcroft JA, Healey A, Murray DG, Boreham PFL, Upcroft P (1992) A gene associated with cell division and drug resistance in Giardia duodenalis. Parasitology 104: 397-405
-
(1992)
Parasitology
, vol.104
, pp. 397-405
-
-
Upcroft, J.A.1
Healey, A.2
Murray, D.G.3
Boreham, P.4
Upcroft, P.5
-
17
-
-
0025801867
-
Structure of the human MDR3 gene and physical mapping of the human MDR locus
-
Lincke CR, Smit JJM, vanderVelde-Koerts T, Borst P (1991) Structure of the human MDR3 gene and physical mapping of the human MDR locus. J Biol Chem 266:5303-5310
-
(1991)
J Biol Chem
, vol.266
, pp. 5303-5310
-
-
Lincke, C.R.1
Smit, J.2
Vandervelde-Koerts, T.3
Borst, P.4
-
18
-
-
0025228519
-
Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells
-
Raymond M, Rose E, Housman DE, Gros P (1990) Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol Cell Biol 10:1642-1651
-
(1990)
Mol Cell Biol
, vol.10
, pp. 1642-1651
-
-
Raymond, M.1
Rose, E.2
Housman, D.E.3
Gros, P.4
-
19
-
-
0023273521
-
Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line
-
Jongsma APM, Spengler BA, Van der Bliek AM, Borst P, Biedler JL (1987) Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line. Cancer Res 47:2875-2878
-
(1987)
Cancer Res
, vol.47
, pp. 2875-2878
-
-
Jongsma, A.1
Spengler, B.A.2
Van Der Bliek, A.M.3
Borst, P.4
Biedler, J.L.5
-
20
-
-
0023916755
-
Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster ovary cells
-
Biedler JL, Chang T, Scotto KW, Mel era PW, Spengler BA (1988) Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster ovary cells. Cancer Res 48:3179-3187
-
(1988)
Cancer Res
, vol.48
, pp. 3179-3187
-
-
Biedler, J.L.1
Chang, T.2
Scotto, K.W.3
Mel Era, P.W.4
Spengler, B.A.5
-
21
-
-
0022972654
-
Internal duplication and homology with bacterial transport proteins in the mdr (P-glycoprotein) gene from multidrug-resistant human cells
-
Chen C-j, Chin CE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB (1986) Internal duplication and homology with bacterial transport proteins in the mdr (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47:381-389
-
(1986)
Cell
, vol.47
, pp. 381-389
-
-
C-J, C.1
Chin, C.E.2
Ueda, K.3
Clark, D.P.4
Pastan, I.5
Gottesman, M.M.6
Roninson, I.B.7
-
22
-
-
0022993652
-
Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
-
Gros P, Croop J, Housman DE (1986) Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47:371-380
-
(1986)
Cell
, vol.47
, pp. 371-380
-
-
Gros, P.1
Croop, J.2
Housman, D.E.3
-
23
-
-
0007003697
-
Mammalian multidrug-resistance gene: Correlation of exon organization with structural domains and duplication of an ancestral gene
-
Raymond M, Gros P (1989) Mammalian multidrug-resistance gene: Correlation of exon organization with structural domains and duplication of an ancestral gene. Proc Natl Acad Sci USA 86:6488-6492
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 6488-6492
-
-
Raymond, M.1
Gros, P.2
-
24
-
-
0025191307
-
Genomic organization of the human multidrug resistance (MDRY) gene and origin of P-glycoproteins
-
Chen C-j, Clark D, Ueda K, Pastan I, Gottesman MM, Roninson IB (1990) Genomic organization of the human multidrug resistance (MDRY) gene and origin of P-glycoproteins. J Biol Chem 265:506-514
-
(1990)
J Biol Chem
, vol.265
, pp. 506-514
-
-
C-J, C.1
Clark, D.2
Ueda, K.3
Pastan, I.4
Gottesman, M.M.5
Roninson, I.B.6
-
25
-
-
0023006005
-
Isolation and characterization of a complementary DNA that confers multidrug resistance
-
Gros P, Ben Neriah Y, Croop J, Housman DE (1986) Isolation and characterization of a complementary DNA that confers multidrug resistance. Nature 323:728-731
-
(1986)
Nature
, vol.323
, pp. 728-731
-
-
Gros, P.1
Ben Neriah, Y.2
Croop, J.3
Housman, D.E.4
-
26
-
-
0008632564
-
Expression of a full-length cDNA for the human ‘MDRV (P-glycoprotein) gene confers multidrug resistance to colchicine, doxorubicin, and vinblastine
-
Ueda K, Cardarelli C, Gottesman MM, Pastan I (1987) Expression of a full-length cDNA for the human ‘MDRV (P-glycoprotein) gene confers multidrug resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Acad Sci USA 84:3004-3008
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 3004-3008
-
-
Ueda, K.1
Cardarelli, C.2
Gottesman, M.M.3
Pastan, I.4
-
27
-
-
0025253133
-
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
-
Devault A, Gros P (1990) Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol 10:1652-1663
-
(1990)
Mol Cell Biol
, vol.10
, pp. 1652-1663
-
-
Devault, A.1
Gros, P.2
-
28
-
-
0024044158
-
Cloning and characterization of a second member of the mouse mdr gene family
-
Gros P, Raymond M, Bell J, Housman DE (1988) Cloning and characterization of a second member of the mouse mdr gene family. Mol Cell Biol 8:2770-2778
-
(1988)
Mol Cell Biol
, vol.8
, pp. 2770-2778
-
-
Gros, P.1
Raymond, M.2
Bell, J.3
Housman, D.E.4
-
29
-
-
0025893114
-
Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies
-
Schinkel AH, Roelofs MEM, Borst P (1991) Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies. Cancer Res 51:2628-2635
-
(1991)
Cancer Res
, vol.51
, pp. 2628-2635
-
-
Schinkel, A.H.1
Roelofs, M.2
Borst, P.3
-
30
-
-
0026640274
-
Gros P (1992) mdrl encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies
-
Buschman E, Arced RJ, Croop JM, Che M, Arias IM, Housman DE, Gros P (1992) mdrl encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J Biol Chem 267:18093-18099
-
(1992)
J Biol Chem
, vol.267
, pp. 18093-18099
-
-
Buschman, E.1
Arced, R.J.2
Croop, J.M.3
Che, M.4
Arias, I.M.5
Housman, D.E.6
-
31
-
-
0023635068
-
Immuno-cytochemical localization of PI 70 at the plasma membrane of multidrug-resistant human cells
-
Willingham MC, Richert ND, Cornwell MM, Tsuruo T, Hamada H, Gottesman MM, Pastan I (1987) Immuno-cytochemical localization of PI 70 at the plasma membrane of multidrug-resistant human cells. J Histochem Cytochem 35:1451-1456
-
(1987)
J Histochem Cytochem
, vol.35
, pp. 1451-1456
-
-
Willingham, M.C.1
Richert, N.D.2
Cornwell, M.M.3
Tsuruo, T.4
Hamada, H.5
Gottesman, M.M.6
Pastan, I.7
-
32
-
-
0025246330
-
Expression of the human multidrug transporter in insect cells by a recombinant baculovirus
-
Germann UA, Willingham MC, Pastan I, Gottesman MM (1990) Expression of the human multidrug transporter in insect cells by a recombinant baculovirus. Biochemistry 29:2295-2303
-
(1990)
Biochemistry
, vol.29
, pp. 2295-2303
-
-
Germann, U.A.1
Willingham, M.C.2
Pastan, I.3
Gottesman, M.M.4
-
33
-
-
0026568159
-
Functional expression of human mdrl in the yeast Sacckaromyces cerevisiae
-
Kuchler K, Thorner J (1992) Functional expression of human mdrl in the yeast Sacckaromyces cerevisiae. Proc Natl Acad Sci USA 89:2302-2306
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2302-2306
-
-
Kuchler, K.1
Thorner, J.2
-
34
-
-
0025951859
-
Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation
-
Zhang JT, Ling V (1991) Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation. J Biol Chem 266:18224-18232
-
(1991)
J Biol Chem
, vol.266
, pp. 18224-18232
-
-
Zhang, J.T.1
Ling, V.2
-
35
-
-
0024441318
-
Cytoplasmic orientation and two-domain structure of the multidrug transporter, P-glycoprotein, demonstrated with sequence-specific antibodies
-
Yoshimura A, Kuwazuru Y, Sumizawa T, Ichikawa M, Ikeda S, Ueda Akiyama S-I (1989) Cytoplasmic orientation and two-domain structure of the multidrug transporter, P-glycoprotein, demonstrated with sequence-specific antibodies. J Biol Chem 264:16282-16291
-
(1989)
J Biol Chem
, vol.264
, pp. 16282-16291
-
-
Yoshimura, A.1
Kuwazuru, Y.2
Sumizawa, T.3
Ichikawa, M.4
Ikeda, S.5
Ueda Akiyama, S.-I.6
-
36
-
-
0024971222
-
Two different regions of P-glycoprotein are photo-affinity labeled by azidopine
-
Bruggemann EP, Germann UA, Gottesman MM, Pastan I (1989) Two different regions of P-glycoprotein are photo-affinity labeled by azidopine. J Biol Chem 264:15483-15488
-
(1989)
J Biol Chem
, vol.264
, pp. 15483-15488
-
-
Bruggemann, E.P.1
Germann, U.A.2
Gottesman, M.M.3
Pastan, I.4
-
37
-
-
0026669363
-
Characterization of the azidopine and vinblastine bindingsite of P-glycoprotein
-
Bruggemann EP, Currier SJ, Gottesman MM, Pastan I (1992) Characterization of the azidopine and vinblastine bindingsite of P-glycoprotein. J Biol Chem 267:21020-21026
-
(1992)
J Biol Chem
, vol.267
, pp. 21020-21026
-
-
Bruggemann, E.P.1
Currier, S.J.2
Gottesman, M.M.3
Pastan, I.4
-
38
-
-
0025702489
-
Dimerization of the P-glycoprotein in membranes
-
Boscoboinik D, Debanne MT, Stafford AR, Jung CY, Gupta RS, Epand RM (1990) Dimerization of the P-glycoprotein in membranes. Biochim Biophys Acta 1027:225-228
-
(1990)
Biochim Biophys Acta
, vol.1027
, pp. 225-228
-
-
Boscoboinik, D.1
Debanne, M.T.2
Stafford, A.R.3
Jung, C.Y.4
Gupta, R.S.5
Epand, R.M.6
-
39
-
-
0026748955
-
Functionally active homodimer of P-glycoprotein in multidrug-resistant tumor cells
-
Naito M, Tsuruo T (1992) Functionally active homodimer of P-glycoprotein in multidrug-resistant tumor cells. Biochem Biophys Res Comm 185:284-290
-
(1992)
Biochem Biophys Res Comm
, vol.185
, pp. 284-290
-
-
Naito, M.1
Tsuruo, T.2
-
40
-
-
0025176784
-
P-glycoproteins in pathology: The multidrug resistance gene family in humans
-
Weinstein RS, Kuszak JR, Kluskens LF, Coon JS (1990) P-glycoproteins in pathology: The multidrug resistance gene family in humans. Hum Pathol 21:34-48
-
(1990)
Hum Pathol
, vol.21
, pp. 34-48
-
-
Weinstein, R.S.1
Kuszak, J.R.2
Kluskens, L.F.3
Coon, J.S.4
-
41
-
-
0023786746
-
Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells
-
Richert ND, Aldwin L, Nitecki D, Gottesman MM, Pastan I (1988) Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. Biochemistry 27:7607-7613
-
(1988)
Biochemistry
, vol.27
, pp. 7607-7613
-
-
Richert, N.D.1
Aldwin, L.2
Nitecki, D.3
Gottesman, M.M.4
Pastan, I.5
-
42
-
-
0013682470
-
Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines
-
Greenberger LM, Lothstein L, Williams SS, Horwitz SB (1988) Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. Proc Natl Acad Sci USA 85:3762-3766
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 3762-3766
-
-
Greenberger, L.M.1
Lothstein, L.2
Williams, S.S.3
Horwitz, S.B.4
-
43
-
-
0026073448
-
Glycosylation of P-glycoprotein in a multidrug-resistant KB cell line, and in human tissues
-
Ichikawa M, Yoshimura A, Furukawa T, Sumizawa T, Nakazima Y, Akiyama S-I (1991) Glycosylation of P-glycoprotein in a multidrug-resistant KB cell line, and in human tissues. Biochim Biophys Acta 1073:309-315
-
(1991)
Biochim Biophys Acta
, vol.1073
, pp. 309-315
-
-
Ichikawa, M.1
Yoshimura, A.2
Furukawa, T.3
Sumizawa, T.4
Nakazima, Y.5
Akiyama, S.-I.6
-
44
-
-
0020082647
-
Continued expression of Vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase
-
Beck WT, Cirtain MC (1982) Continued expression of Vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase. Cancer Res 42:184-189
-
(1982)
Cancer Res
, vol.42
, pp. 184-189
-
-
Beck, W.T.1
Cirtain, M.C.2
-
45
-
-
0021059566
-
The multidrug resistance phenotype in Chinese hamster ovary cells
-
Ling V, Kartner N, Sudo T, Siminovitch L, Riordan JR (1983) The multidrug resistance phenotype in Chinese hamster ovary cells. Cancer Treat Rep 67:869-874
-
(1983)
Cancer Treat Rep
, vol.67
, pp. 869-874
-
-
Ling, V.1
Kartner, N.2
Sudo, T.3
Siminovitch, L.4
Riordan, J.R.5
-
46
-
-
0026585065
-
Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene
-
Raymond M, Gros P, Whiteway M, Thomas DY (1992) Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene. Science 256:232-234
-
(1992)
Science
, vol.256
, pp. 232-234
-
-
Raymond, M.1
Gros, P.2
Whiteway, M.3
Thomas, D.Y.4
-
47
-
-
0026184159
-
Expression of human P-glycoprotein in yeast cells—effects of membrane component sterols on the activity of P-glycoprotein
-
Saeki T, Shimabuku AM, Azuma Y, Shibano Y, Komano T, Ueda T (1991) Expression of human P-glycoprotein in yeast cells—effects of membrane component sterols on the activity of P-glycoprotein. Agric Biol Chem 55:1859-1865
-
(1991)
Agric Biol Chem
, vol.55
, pp. 1859-1865
-
-
Saeki, T.1
Shimabuku, A.M.2
Azuma, Y.3
Shibano, Y.4
Komano, T.5
Ueda, T.6
-
48
-
-
0025945570
-
Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine
-
Ma L, Marquard D, Takemoto L, Center MS (1991) Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine. J Biol Chem 266:5593-5599
-
(1991)
J Biol Chem
, vol.266
, pp. 5593-5599
-
-
Ma, L.1
Marquard, D.2
Takemoto, L.3
Center, M.S.4
-
49
-
-
0025318529
-
Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells
-
Chambers TC, McAvoy EM, Jacobs JW, Eilon G (1990) Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. J Biol Chem 265:7679-7686
-
(1990)
J Biol Chem
, vol.265
, pp. 7679-7686
-
-
Chambers, T.C.1
McAvoy, E.M.2
Jacobs, J.W.3
Eilon, G.4
-
50
-
-
0027076780
-
Regulation by phorbol ester and protein kinase-C inhibitors, and by a protein phosphatase inhibitor (Okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human-KB cells
-
Chambers TC, Zheng B, Kuo JF (1992) Regulation by phorbol ester and protein kinase-C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human-KB cells. Mol Pharmacol 41:1008-1015
-
(1992)
Mol Pharmacol
, vol.41
, pp. 1008-1015
-
-
Chambers, T.C.1
Zheng, B.2
Kuo, J.F.3
-
51
-
-
0023508529
-
Phosphorylation of the multidrug resistance associated glycoprotein
-
M ell ado W, Horwitz SB (1987) Phosphorylation of the multidrug resistance associated glycoprotein. Biochemistry 26:6900-6904
-
(1987)
Biochemistry
, vol.26
, pp. 6900-6904
-
-
Ell Ado, W.1
Horwitz, S.B.2
-
52
-
-
0025231578
-
Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein
-
Staats J, Marquardt D, Center MS (1990) Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein. J Biol Chem 265:4084-4090
-
(1990)
J Biol Chem
, vol.265
, pp. 4084-4090
-
-
Staats, J.1
Marquardt, D.2
Center, M.S.3
-
53
-
-
0001607723
-
Gay NJ (1982) Distantly related sequences in the a- and /J-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
-
Walker JE, Saraste M, Runswick MJ: Gay NJ (1982) Distantly related sequences in the a- and /J-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J 1:945-951
-
(1982)
EMBO J
, vol.1
, pp. 945-951
-
-
Walker, J.E.1
Saraste, M.2
Runswick, M.J.3
-
54
-
-
0025374695
-
Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
-
Hyde SC, Emsley P, Hartshorn MJ, Mimmack MM, Gileadi U, Pearce SR, Gallagher MP, Gill DR, Hubbard RE, Higgins CF (1990) Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346:362-365
-
(1990)
Nature
, vol.346
, pp. 362-365
-
-
Hyde, S.C.1
Emsley, P.2
Hartshorn, M.J.3
Mimmack, M.M.4
Gileadi, U.5
Pearce, S.R.6
Gallagher, M.P.7
Gill, D.R.8
Hubbard, R.E.9
Higgins, C.F.10
-
55
-
-
0024307162
-
Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr gene abolish its ability to confer multidrug resistance
-
Azzaria M, Schurr E, Gros P (1989) Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr gene abolish its ability to confer multidrug resistance. Mol Cell Biol 9:5289-5297
-
(1989)
Mol Cell Biol
, vol.9
, pp. 5289-5297
-
-
Azzaria, M.1
Schurr, E.2
Gros, P.3
-
56
-
-
0026068740
-
Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdrl and mdr2 genes
-
Buschman E, Gros P (1991) Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdrl and mdr2 genes. Mol Cell Biol 11:595-603
-
(1991)
Mol Cell Biol
, vol.11
, pp. 595-603
-
-
Buschman, E.1
Gros, P.2
-
57
-
-
0024365830
-
Deletion and insertion mutants of the multidrug transporter
-
Currier SJ, Ueda K, Willingham MC, Pastan I, Gottesman MM (1989) Deletion and insertion mutants of the multidrug transporter. J Biol Chem 264:14376-14381
-
(1989)
J Biol Chem
, vol.264
, pp. 14376-14381
-
-
Currier, S.J.1
Ueda, K.2
Willingham, M.C.3
Pastan, I.4
Gottesman, M.M.5
-
58
-
-
0026755153
-
Functional analysis of chimeric proteins constructed by exchanging homologous domains of two P-glycoproteins conferring distinct drug resistance profiles
-
Dhir R, Gros P (1992) Functional analysis of chimeric proteins constructed by exchanging homologous domains of two P-glycoproteins conferring distinct drug resistance profiles. Biochemistry 31:6103-6110
-
(1992)
Biochemistry
, vol.31
, pp. 6103-6110
-
-
Dhir, R.1
Gros, P.2
-
59
-
-
0024292717
-
An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdrl (P-glycoprotein) gene
-
Choi K, Chen C-J, Kriegler M, Roninson IB (1989) An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdrl (P-glycoprotein) gene. Cell 53:519-529
-
(1989)
Cell
, vol.53
, pp. 519-529
-
-
Choi, K.1
Chen, C.-J.2
Kriegler, M.3
Roninson, I.B.4
-
60
-
-
0024362996
-
P-glycoprotein gene (MDRl) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance
-
Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I, Ueda K (1989) P-glycoprotein gene (MDRl) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance. Biochem Biophys Res Comm 162:224-231
-
(1989)
Biochem Biophys Res Comm
, vol.162
, pp. 224-231
-
-
Kioka, N.1
Tsubota, J.2
Kakehi, Y.3
Komano, T.4
Gottesman, M.M.5
Pastan, I.6
Ueda, K.7
-
61
-
-
0025051429
-
Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly to Val-185 substitution in P-glycoprotein
-
Safa AR, Stern RK, Choi K, Agresti M, Tamai I, Mehta ND, Roninson IB (1990) Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly to Val-185 substitution in P-glycoprotein. Proc Natl Acad Sci USA 87:7225-7229
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 7225-7229
-
-
Safa, A.R.1
Stern, R.K.2
Choi, K.3
Agresti, M.4
Tamai, I.5
Mehta, N.D.6
Roninson, I.B.7
-
62
-
-
0026556302
-
Amino acid substitutions in the 6th transmembrane domain of P-glycoprotein alter multidrug resistance
-
Devine SE, Ling V, Melera PW (1992) Amino acid substitutions in the 6th transmembrane domain of P-glycoprotein alter multidrug resistance. Proc Natl Acad Sci USA 89:4564-4568
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4564-4568
-
-
Devine, S.E.1
Ling, V.2
Melera, P.W.3
-
63
-
-
0025766958
-
A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr 1 and mdr* drug efflux pumps
-
Gros P, Dhir R, Croop J, Talbot F (1991) A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr 1 and mdr* drug efflux pumps. Proc Natl Acad Sci USA 88:7289-7293
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 7289-7293
-
-
Gros, P.1
Dhir, R.2
Croop, J.3
Talbot, F.4
-
64
-
-
0026473238
-
Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR X-MDR2 transporters
-
Currier SJ, Kane SE, Willingham MC, Cardarelli CO, Pastan I, Gottesman MM (1992) Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR X-MDR2 transporters. J Biol Chem 267:25153-25159
-
(1992)
J Biol Chem
, vol.267
, pp. 25153-25159
-
-
Currier, S.J.1
Kane, S.E.2
Willingham, M.C.3
Cardarelli, C.O.4
Pastan, I.5
Gottesman, M.M.6
-
65
-
-
0024523014
-
Expression of a multidrug resistance-adenosine deaminase fusion gene
-
Germann UA, Gottesman MM, Pastan I (1989) Expression of a multidrug resistance-adenosine deaminase fusion gene. J Biol Chem 264:7418-7424
-
(1989)
J Biol Chem
, vol.264
, pp. 7418-7424
-
-
Germann, U.A.1
Gottesman, M.M.2
Pastan, I.3
-
66
-
-
0026756347
-
P-glycoprotein-ATP hydrolysis by the N-terminal nucleotide-binding domain
-
Shimabuku AM, Nishimoto T, Ueda K, Komano T (1992) P-glycoprotein-ATP hydrolysis by the N-terminal nucleotide-binding domain. J Biol Chem 267:4308-4311
-
(1992)
J Biol Chem
, vol.267
, pp. 4308-4311
-
-
Shimabuku, A.M.1
Nishimoto, T.2
Ueda, K.3
Komano, T.4
-
67
-
-
0026723940
-
ATP and GTP as alternative energy sources for vinblastine transport by P-170 in KB-VI plasma membrane vesicles
-
Lelong IH, Padmanabhan R, Lovelace E, Pastan I, Gottesman MM (1992) ATP and GTP as alternative energy sources for vinblastine transport by P-170 in KB-VI plasma membrane vesicles. FEBS Lett 304:256-260
-
(1992)
FEBS Lett
, vol.304
, pp. 256-260
-
-
Lelong, I.H.1
Padmanabhan, R.2
Lovelace, E.3
Pastan, I.4
Gottesman, M.M.5
-
68
-
-
0025951663
-
Interaction of forskolin with the P-glycoprotein multidrug transporter
-
Morris DI, Speicher LA, Ruoho AE, Tew KD, Seamon KB (1991) Interaction of forskolin with the P-glycoprotein multidrug transporter. Biochemistry 30:8371-8379
-
(1991)
Biochemistry
, vol.30
, pp. 8371-8379
-
-
Morris, D.I.1
Speicher, L.A.2
Ruoho, A.E.3
Tew, K.D.4
Seamon, K.B.5
-
69
-
-
0026501892
-
Photoaffinily substrates for P-glycoprotein
-
Bcck WT, Q_ian X-D (1992) Photoaffinily substrates for P-glycoprotein. Biochem Pharmacol 43:89-93
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 89-93
-
-
Bcck, W.T.1
Q_Ian, X.-D.2
-
70
-
-
0025872032
-
Domain mapping of the photoaffmity drug-binding sites in P-glycoprotein encoded mouse mdrh
-
Greenberger LM, Lisanti CJ, Silva JT, Horwitz SB (1991) Domain mapping of the photoaffmity drug-binding sites in P-glycoprotein encoded mouse mdrh. J Biol Chem 266: 20744-20751
-
(1991)
J Biol Chem
, vol.266
, pp. 20744-20751
-
-
Greenberger, L.M.1
Lisanti, C.J.2
Silva, J.T.3
Horwitz, S.B.4
-
71
-
-
0015963429
-
Reduced permeability in CHO cells as a mechanism of resistance to colchicine
-
Ling V, Thompson LH (1974) Reduced permeability in CHO cells as a mechanism of resistance to colchicine. J Cell Physiol 83:103-116
-
(1974)
J Cell Physiol
, vol.83
, pp. 103-116
-
-
Ling, V.1
Thompson, L.H.2
-
72
-
-
0015893137
-
Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells
-
Dantf K (1973) Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells. Biochem Biophys Acta 323:466-483
-
(1973)
Biochem Biophys Acta
, vol.323
, pp. 466-483
-
-
Dantf, K.1
-
73
-
-
0007630205
-
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells
-
Horio M, Gottesman MM, Pastan I (1988) ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci USA 85:3580-3584
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 3580-3584
-
-
Horio, M.1
Gottesman, M.M.2
Pastan, I.3
-
74
-
-
0026015565
-
Agents which reverse multidrug-resistance are inhibitors of 3H-vinblastine transport by isolated vesicles
-
Horio M, Lovelace E, Pastan I, Gottesman MM (1991) Agents which reverse multidrug-resistance are inhibitors of 3H-vinblastine transport by isolated vesicles. Biochim Biophys Acta 1061:106-110
-
(1991)
Biochim Biophys Acta
, vol.1061
, pp. 106-110
-
-
Horio, M.1
Lovelace, E.2
Pastan, I.3
Gottesman, M.M.4
-
75
-
-
0024371025
-
The function of Gpl70, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
-
Kamimoto Y, Gatmaitan Z, Hsu J, Arias IM (1989) The function of Gpl70, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem 264:11693-11698
-
(1989)
J Biol Chem
, vol.264
, pp. 11693-11698
-
-
Kamimoto, Y.1
Gatmaitan, Z.2
Hsu, J.3
Arias, I.M.4
-
76
-
-
0024449848
-
Trans-epithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia
-
Horio M, Chin K-V, Currier SJ, Goldenberg S, Williams C, Pastan I, Gottesman MM, Handler J (1989) Trans-epithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia. J Biol Chem 264:14880-14884
-
(1989)
J Biol Chem
, vol.264
, pp. 14880-14884
-
-
Horio, M.1
Chin, K.-V.2
Currier, S.J.3
Goldenberg, S.4
Williams, C.5
Pastan, I.6
Gottesman, M.M.7
Handler, J.8
-
77
-
-
0026500180
-
The function of Gpl70, the multidrug resistance gene product, in the brush border of rat intestinal mucosa
-
Hsing S, Gatmaitan Z, Arias IM (1992) The function of Gpl70, the multidrug resistance gene product, in the brush border of rat intestinal mucosa. Gastroenterology 102:879-885
-
(1992)
Gastroenterology
, vol.102
, pp. 879-885
-
-
Hsing, S.1
Gatmaitan, Z.2
Arias, I.M.3
-
78
-
-
0023840065
-
Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance—170- to 180-kilodalton membrane glycoprotein is an ATPase
-
Hamada H, Tsuruo T (1988) Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance—170- to 180-kilodalton membrane glycoprotein is an ATPase. J Biol Chem 263:1454-1458
-
(1988)
J Biol Chem
, vol.263
, pp. 1454-1458
-
-
Hamada, H.1
Tsuruo, T.2
-
79
-
-
0026722467
-
Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase
-
Sarkadi B, Price EM, Boucher RC, Germann UA, Scarborough GA (1992) Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. J Biol Chem 267: 4854-4858
-
(1992)
J Biol Chem
, vol.267
, pp. 4854-4858
-
-
Sarkadi, B.1
Price, E.M.2
Boucher, R.C.3
Germann, U.A.4
Scarborough, G.A.5
-
80
-
-
0026146750
-
Production of a site specifically cleavable P-glycoprotein-8-galactosidase fusion protein
-
Shimabuku AM, Saeki T, Ueda K, Komano T (1991) Production of a site specifically cleavable P-glycoprotein-8-galactosidase fusion protein. Agric Biol Chem 55: 1075-1080
-
(1991)
Agric Biol Chem
, vol.55
, pp. 1075-1080
-
-
Shimabuku, A.M.1
Saeki, T.2
Ueda, K.3
Komano, T.4
-
81
-
-
0026662530
-
Partial purification and ‘ reconstitution of the human multidrug resistance pump: Characterization of the drug-stimulatable ATP hydrolysis
-
Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I (1992) Partial purification and ‘ reconstitution of the human multidrug resistance pump: Characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci USA 89:8472-8476
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 8472-8476
-
-
Ambudkar, S.V.1
Lelong, I.H.2
Zhang, J.3
Cardarelli, C.O.4
Gottesman, M.M.5
Pastan, I.6
-
82
-
-
0026051623
-
Laser scanning and confocal microscopy of daunorubicin, doxorubicin and rhodamine 123 in multidrug-resistant cells
-
Weaver JL, Ine PS, Aszalos A, Schoenlein PV, Currier SJ, Padmanabhan R, Gottesman MM (1991) Laser scanning and confocal microscopy of daunorubicin, doxorubicin and rhodamine 123 in multidrug-resistant cells. Exp Cell Res 196:323-329
-
(1991)
Exp Cell Res
, vol.196
, pp. 323-329
-
-
Weaver, J.L.1
Ine, P.S.2
Aszalos, A.3
Schoenlein, P.V.4
Currier, S.J.5
Padmanabhan, R.6
Gottesman, M.M.7
-
83
-
-
0025193531
-
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells
-
Raviv Y, Pollard HP, Bruggemann EP, Pastan I, Gottesman MM (1990) Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. J Biol Chem 265:3975-3980
-
(1990)
J Biol Chem
, vol.265
, pp. 3975-3980
-
-
Raviv, Y.1
Pollard, H.P.2
Bruggemann, E.P.3
Pastan, I.4
Gottesman, M.M.5
-
84
-
-
0026674983
-
Peptide transport by the multidrug resistance pump
-
Sharma RC, Inoue S, Roitelman J, Schimke RT, Simoni RD (1992) Peptide transport by the multidrug resistance pump. J Biol Chem 267:5731-5734
-
(1992)
J Biol Chem
, vol.267
, pp. 5731-5734
-
-
Sharma, R.C.1
Inoue, S.2
Roitelman, J.3
Schimke, R.T.4
Simoni, R.D.5
-
85
-
-
0026536805
-
Volume-regulated chloride channels associated with the human multidrug resistance P-glycoprotein
-
Valverde MA, Diaz M, Sepulveda FV, Gill DR, Hyde SC, Higgins CF (1992) Volume-regulated chloride channels associated with the human multidrug resistance P-glycoprotein. Nature 355:830-833
-
(1992)
Nature
, vol.355
, pp. 830-833
-
-
Valverde, M.A.1
Diaz, M.2
Sepulveda, F.V.3
Gill, D.R.4
Hyde, S.C.5
Higgins, C.F.6
-
86
-
-
0025868103
-
Demonstration that CFTR is a chloride channel by alteration of its anion selectivity
-
Anderson MP, Gregory RJ, Thompson S, Souza DW, Paul S, Mulligan RC, Smith AE, Welsh MJ (1991) Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 253:202-205
-
(1991)
Science
, vol.253
, pp. 202-205
-
-
Anderson, M.P.1
Gregory, R.J.2
Thompson, S.3
Souza, D.W.4
Paul, S.5
Mulligan, R.C.6
Smith, A.E.7
Welsh, M.J.8
-
87
-
-
0025931429
-
Nucleotide triphosphates are required to open the CFTR channel
-
Anderson MP, Berger HA, Rich DP, Gregory RJ, Smith AE, Welsh MJ (1991) Nucleotide triphosphates are required to open the CFTR channel. Cell 67:775-784
-
(1991)
Cell
, vol.67
, pp. 775-784
-
-
Anderson, M.P.1
Berger, H.A.2
Rich, D.P.3
Gregory, R.J.4
Smith, A.E.5
Welsh, M.J.6
-
88
-
-
0026775053
-
Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein
-
Gill DR, Hyde SC, Higgins CF, Valverde MA, Mintenig GM, Sepulveda FV (1992) Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein. Cell 71:23-32
-
(1992)
Cell
, vol.71
, pp. 23-32
-
-
Gill, D.R.1
Hyde, S.C.2
Higgins, C.F.3
Valverde, M.A.4
Mintenig, G.M.5
Sepulveda, F.V.6
-
89
-
-
0026451638
-
The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression
-
Trezise AEO, Romano PR, Gill DR, Hyde SC, Sepulveda FV, Buchwald M, Higgins CF (1992) The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression. EMBO J 11:4291-4303
-
(1992)
EMBO J
, vol.11
, pp. 4291-4303
-
-
Trezise, A.1
Romano, P.R.2
Gill, D.R.3
Hyde, S.C.4
Sepulveda, F.V.5
Buchwald, M.6
Higgins, C.F.7
-
90
-
-
0025799513
-
Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
-
Chaudhary PM, Roninson IB (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66:85-94
-
(1991)
Cell
, vol.66
, pp. 85-94
-
-
Chaudhary, P.M.1
Roninson, I.B.2
-
91
-
-
0026707951
-
P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid
-
Wolf DC, Horwitz SB (1992) P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid. Int J Cancer 52:141-146
-
(1992)
Int J Cancer
, vol.52
, pp. 141-146
-
-
Wolf, D.C.1
Horwitz, S.B.2
-
92
-
-
0026755547
-
Reduced messenger RNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines
-
Chin K-V, Chauhan SS, Abraham I, Sampson KE, Krolczyk AJ, Wong M, Schimmer B, Pastan I, Gottesman MM (1992) Reduced messenger RNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines. J Cell Physiol 152:87-94
-
(1992)
J Cell Physiol
, vol.152
, pp. 87-94
-
-
Chin, K.-V.1
Chauhan, S.S.2
Abraham, I.3
Sampson, K.E.4
Krolczyk, A.J.5
Wong, M.6
Schimmer, B.7
Pastan, I.8
Gottesman, M.M.9
|