Rationally designed 'dipeptoid' analogues of cholecystokinin (CCK): N-terminal structure-affinity relationships of α-methyl-tryptophan derivatives

European Journal of Medicinal Chemistry

Volumn 28, Issue 1, 1993, Pages 37-45

  Eden, JM ^a   Higginbottom, M ^a   Hill, DR ^a   Horwell, DC ^a   Hunter, JC ^a   Martin, K ^a   Pritchard, MC ^a   Rahman, SS ^a   Richardson, RS ^a   Roberts, E ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

cholecystokinin; dipeptoid analogues; N terminal; structure affinity relationships; methyl tryptophan derivatives

Indexed keywords

[1 (1H INDOL 3 YLMETHYL) 1 METHYL 2 OXO 2 [(2 PHENYLETHYL)AMINO]ETHYL]CARBAMIC ACID TRICYCLO[3.3.1.1(3,7)]DEC 7 YL ESTER; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ DERIVATIVE; CHOLECYSTOKININ OCTAPEPTIDE; PEPTIDE DERIVATIVE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0027537791     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/0223-5234(93)90077-R     Document Type: Article

References (28)

1. New peptide in the vertebrate CNS reacting with antigastrin antibodies
2. Cholecystokinin receptor antagonists
3. 8-Substituted Xanthines as Phosphodiesterase Inhibitors: Conformation-Dependent Lipophilicity and Structure-Activity Relationships