Female hypogonadotropic hypogonadism: Hypothalamic amenorrhea syndrome

Endocrinology and Metabolism Clinics of North America

Volumn 22, Issue 1, 1993, Pages 29-58

  Yen, S S C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; FOLLITROPIN; GONADORELIN; GROWTH HORMONE; LUTEINIZING HORMONE; MELATONIN; THYROTROPIN;

AMENORRHEA AND OLIGOMENORRHEA; CIRCADIAN RHYTHM; EXERCISE; FEMALE GENITAL SYSTEM; GONADORELIN RELEASE; HORMONAL REGULATION; HUMAN; HYPERCORTISOLISM; HYPOGONADOTROPIC HYPOGONADISM; HYPOPITUITARISM; HYPOTHALAMUS; KALLMANN SYNDROME; MENSTRUATION DISORDER; NUTRITIONAL STATUS; ONTOGENY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVIEW; SEXUAL MATURATION;

EID: 0027537267     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0889-8529(18)30179-8     Document Type: Review

References (134)

1. Ackland J.F. Nikolics K. Seeburg P. Molecular forms of gonadotropin-releasing hormone associated peptide (GAP): Changes within the rat hypothalamus and release from hypothalamic cells in vitro Neuroendocrinology 48 1988 376
2. Albright F. Halsted J. Studies on ovarian dysfunction II: The application of the ‘hormonal measuring sticks’ to the sorting out and to the treatment of the various types of amenorrhea, NEJM 212 1935 250
3. Anthony E.L.P. King J.C. Stopa E.G. Immunocytochemical neurohypophysis: Evidence for multiple sites of releasing hormone secretion in humans and other mammals Cell Tissue Res 236 1984 5
4. Apter D. Viinikka L. Vihko R. Hormonal pattern of adolescent menstrual cycles J Clin Endocrinol Metab 47 1978 944
5. Aschoff J. The circadian system in man Krieger D.T. Hughes J.C. Neuroendocrinology 1980 Sinauer Associates Sunderland, MA 77
6. Barry J. Barette B. Immunofluorescence study of LRF neurons in primates Cell Tissue Res 164 1975 163
7. Berga SL, Loucks AB, Rossmanith WG, et al: Acceleration of LH pulse frequency in functional hypothalamic amenorrhea by dopaminergic blockade. J Clin Endocrinol Metab, in press 1990
8. Berga S.L. Mortola J.F. Girton L. Neuroendocrine aberrations in women with functional hypothalamic amenorrhea J Clin Endocrinol Metab 68 1989 301
9. Berga S.L. Mortola J.F. Yen S.S.C. Amplification of nocturnal melatonin secretion in women with functional hypothalamic amenorrhea J Clin Endocrinol Metab 66 1988 242
10. Bestie J. Extragonadal endodermal sinus tumors originating in the region of the pineal gland Acta Pathol Microbiol Immunol Scand 74 1968 214
11. Biller B.M.K. Federoff H.J. Koenig J.I. Abnormal cortisol secretion and response to corticotropin-releasing hormone in women with hypothalamic amenorrhea J Clin Endocrinol Metab 70 1990 311
12. Bloch B. Gaillard R.C. Culler M.D. Immunohistochemical detection of proluteinizing hormone-releasing hormone peptides in neurons in the human hypothalamus J Clin Endocrinol Metab 74 1992 135
13. Borit A. Embryonal carcinoma of the pineal region J Pathol 97 1969 165
14. Braunstein G.D. Kohler P.O. Pituitary function in Hand-Schüller-Christian disease: Evidence for deficient growth hormone release in patients with short stature NEJM 286 1972 1225
15. Bullen B.A. Skrinar G.S. Beitins I.Z. Induction of menstrual disorders in untrained women by strenuous exercise NEJM 312 1985 1349
16. Carmel P.W. Araki S. Ferin M. Pituitary stalk portal blood collection in rhesus monkeys: Evidence for pulsatile release of GnRH Endocrinology 99 1976 243
17. Clarke I.J. Cummins J.T. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes Endocrinology 111 1982 1737
18. Crist D.M. Hill J.M. Diet and insulinlike growth factor I in relation to body composition in women with exercise-induced hypothalamic amenorrhea J Am Coll Nutrition 9 1990 200
19. Crowley W.F. Jr. Filicori M. Spratt D. The physiology of gonadotropin-releasing hormone (GnRH) secretion in men and women Rec Prog Horm Res 41 1985 473
20. Cumming D.C. Vickovic M.M. Wall S.R. Defects in pulsatile LH release in normally menstruating runners J Clin Endocrinol Metab 60 1985 810
21. Cumming DC, Wheeler GD: Exercise-associated changes in reproduction: A problem common to women and men. In Reisch RE, (ed): Adipose Tissue and Reproduction, 1990, pp 125–135
22. Dale E. Gerlach D.H. Wilhite A.L. Menstrual dysfunction in distance runners Obstet Gynecol 54 1979 47
23. De Morsier G. Etudes sur les dysraphies cranioencephaliques Schweiz Arch Neurol Neurochir Psychiat 74 1954 309
24. Ding J.H. Scheckter C.B. Drinkwater B.L. High serum cortisol levels in exercise-associated amenorrhea Ann Intern Med 108 1988 530
25. Drinkwater B.L. Nilson K. Chesnut C.H. III Bone mineral content of amenorrheic and eumenorrheic athletes NEJM 311 1984 277
26. Dünger D.B. Broadbent V. Yeoman E. The frequency and natural history of diabetes insipidus in children with Langerhans-cell histiocytosis NEJM 321 1989 1157
27. Fairman C. Hoffman D.L. Ryan R.J. The “fertile eunuch” syndrome: Demonstration of isolated luteinizing hormone deficiency by radioimmunoassay technique Mayo Clin Proc 43 1968 661
28. Felig P. Wahren J. Fuel homeostasis in exercise NEJM 293 1975 1078
29. Fichter M.M. Pirke K.M. Hypothalamic pituitary function in starving healthy subjects Pirke K.M. Ploog D. The Psychobiology of Anorexia Nervosa 1984 Springer-Verlag Berlin 124 135
30. Fideleff H. Aparicio N.J. Guitelman A. Effect of melatonin on the basal and stimulated gonadotropin levels in normal men and postmenopausal women J Clin Endocrinol Metab 42 1976 1014
31. Finkeistein J.S. Spratt D.I. O’Dea L.S.L. Pulsatile gonadotropin secretion after discontinuation of long term gonadotropin-releasing hormone (GnRH) administration in a subset of GnRH-deficient men J Clin Endocrinol Metab 69 1989 377
32. Franco B. Guioli S. Pragliola A. A gene deleted in Kallmann’s syndrome shares homology with neural cell adhesion and axonal path-finding molecules Nature 353 1991 529
33. Friis-Hansen B. Hydrometry of growth and aging Brozek J. Human Body Composition: Approaches and Applications, vol VII, Symposia Soc Study of Human Biology 1965 Oxford Pergamon 191 209
34. Frisch RE: Body fat, menarche, fitness and fertility. In Reisch RE (ed): Adipose Tissue and Reproduction, 1990, pp 1–26
35. Frisch R.E. McArthur J.W. Menstrual cycles: Fatness as a determinant of minimum weight for height necessary for their maintenance or onset Science 185 1974 949
36. Frisch R.E. Wyshak G. Albright N.L. Lower prevalence of breast cancer and cancers of the reproductive system among former college athletes compared to nonathletes Br J Cancer 52 1985 885
37. Galbo H. Christensen N.J. Mikines K.J. The effect of fasting on the hormonal response to graded exercise J Clin Endocrinol Metab 52 1981 1106
38. Gambacciani M. Yen S.S.C. Rasmussen D.D. GnRH release from the medial basal hypothalamus: In vitro inhibition by corticotropin-releasing factor Neuroendocrinology 43 1986 533
39. Gelato M.C. Loriaux D.L. Merriam G.R. Growth hormone responses to growth hormone-releasing hormone in Hand-Schüller-Christian disease Neuroendocrinology 50 1989 259
40. Gharib S.D. Wierman M.E. Shupnik M.A. Molecular biology of the pituitary gonadotropins Endocr Rev 11 1990 177
41. Gold P.W. Loriaux D.L. Roy A. Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing’s disease NEJM 314 1986 1329
42. Goldenberg R.L. Powell R.D. Rosen S.W. Ovarian morphology in women with anosmia and hypogonadotropic hypogonadism Am J Obstet Gynecol 126 1976 91
43. Hazum E. Conn P.M. Molecular mechanism of gonadotropin releasing hormone (GnRH) action. I: The GnRH receptor Endocr Rev 9 1988 379
44. Hermanussen M. Sippell W.G. Heterogeneity of Kallmann’s syndrome Clin Genet 28 1985 106
45. Hoff J.T. Patterson R.H. Jr. Craniopharyngiomas in children and adults J Neurosurg 36 1972 299
46. Hoffman A.R. Crowley W.F. Jr. Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone NEJM 307 1982 1237
47. Ishizuka B. Quigley M.E. Yen S.S.C. Pituitary hormone release in response to food ingestion: Evidence for neuroendocrine signals from gut to brain J Clin Endocrinol Metab 57 1983 1111
48. Jenkins J.S. Gilbert J. Ang V. Hypothalamic-pituitary function in patients with craniopharyngiomas J Clin Endocrinol Metab 43 1976 394
49. Kallmann F.J. Schoenfeld W.A. Barrera S.E. The genetic aspects of primary eunuchoidism Am J Ment Defic 48 1944 203
50. Kapen S. Boyar R.M. Finkeistein J.W. Effect of sleep-wake cycle reversal on luteinizing hormone secretory pattern in puberty J Clin Endocrinol Metab 39 1974 293
51. Kaplan S.L. Grumbach M.M. Aubert M.L. The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: Maturation of central nervous system regulation of anterior pituitary function Recent Prog Horm Res 32 1976 161
52. Kelly M.J. Garrett J. Bosch M.A. Effects of ovariectomy on GnRH mRNA, pro-GnRH and GnRH levels in the preoptic hypothalamus of the female rat Neuroendocrinology 49 1989 88
53. 2-adrenergic agonist J Clin Endocrinol Metab 64 1987 755
54. Klinefelter H.F. Jr. Albright F. Griswold G.C. Experience with a quantitative test for normal or decreased amounts of follicle-stimulating hormone in the urine in endocrinological diagnosis J Clin Endocrinol Metab 3 1943 529
55. Knobil E. The electrophysiology of the GnRH pulse generator J Steroid Biochem 33 1989 669
56. Kreiger D.T. Liotta A.S. Pituitary hormones in brain: Where, how, and why? Science 206 1979 366
57. Lachelin G.C.L. Yen S.S.C. Hypothalamic chronic anovulation Am J Obstet Gynecol 130 1978 825
58. Lam K.S.L. Tse V.K.C. Wang C. Early effects of cranial irradiation on hypothalamic-pituitary function J Clin Endocrinol Metab 64 1987 418
59. Lamon-Fava S. Fischer E.C. Nelson M.E. Effect of exercise and menstrual cycle status on plasma lipids, low density lipoprotein particle size, and apolipoproteins J Clin Endocrinol Metab 68 1989 17
60. Laughlin G. Loucks A. Yen S.S.C. Marked augmentation of nocturnal melatonin secretion in amenorrheic athletes but not in eumenorrheic athletes J Clin Endocrinol Metab 73 1991 1321
61. Lee R.B. Kung San Men, Women and Work in a Foraging Society 1978 Cambridge University Press New York
62. Leyendecker G. Wildt L. Hansmann M. Pregnancies following chronic intermittent (pulsatile) administration of GnRH by means of a portable pump (Zyklomat): A new approach in the treatment of infertility in hypothalamic amenorrhea J Clin Endocrinol Metab 51 1980 1214
63. Lichtenstein L. Histiocytosis X, integration of eosinophilic granuloma of bone, Letterer-Siwe disease and Schüller-Christian disease as related manifestations of a single nosologic entity Arch Pathol 56 1953 84
64. Littley M.D. Shalet S.M. Beardwell C.G. Radiation-induced hypopituitarism is dose-dependent Clin Endocrinol 31 1989 363
65. Liu J.H. Durfee R. Muse K. Induction of multiple ovulation by pulsatile administration of gonadotropin releasing hormone (GnRH) Fertil Steril 40 1983 18
66. Longcope C. Pratt J.H. Schneider S.H. Aromatization of androgens by muscle and adipose tissue in vivo J Clin Endocrinol Metab 46 1978 16
67. Loucks A.B. Horvath S.M. Athletic amenorrhea: A review Med Sei Sports Exer 17 1985 56
68. Loucks AB, Laughlin G, Yen SSC: Thyroid hormone deficiency in women athletes. J Clin Endocrinol Metab, in press 1992
69. Loucks A.B. Mortola J.F. Girton L. Alterations in the hypothalamic-pituitary-ovarian and the hypothalamic-pituitary-adrenal axes in athletic women J Clin Endocrinol Metab 68 1989 402
70. Luger A. Deuster P.A. Kyle S.B. Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise NEJM 316 1987 1309
71. Malina R.M. Spirduso W.W. Tate C. Age at menarche and selected menstrual characteristics in athletes at different competitive levels and in different sports Med Sei Sports 10 1978 218
72. Marcus R. Cann C. Madvig P. Menstrual function and bone mass in elite women distance runners Ann Intern Med 102 1985 158
73. Matsuo H. Baba Y. Nair R.M. Structure of the porcine LH- and FSH-releasing hormone. I: The proposed amino acid sequence Biochem Biophys Res Commun 43 1971 1334
74. Medhamurthy R. Gay V.L. Plant T.M. The prepubertal hiatus in gonadotropin secretion in the male rhesus monkey (Macaca mulatta) does not appear to involve endogenous opioid peptide restraint of hypothalamic gonadotropin-releasing hormone release Endocrinology 126 1990 1036
75. Miller D.S. Reid R. Cetel N. Pulsatile administration of low dose gonadotropinreleasing hormone (GnRH) for the induction of ovulation and pregnancy in patients with hypothalamic amenorrhea JAMA 250 1983 2937
76. Moore-Ede M.C. Czeisler C.A. Richardson G.S. Circadian timekeeping in health and disease NEJM 309 1983 530
77. Nezelof C. Basset F. Rousseau M.F. Histiocytosis X. Histogenetic arguments for a Langerhans cell origin Biomedicine 18 1973 365
78. Olster D.H. Ferin M. Corticotropin-releasing hormone inhibits gonadotropin secretion in the ovariectomized rhesus monkey J Clin Endocrinol Metab 65 1987 262
79. Page R.B. Directional pituitary blood flow: A microcine-photographic study Endocrinology 112 1983 157
80. Paradisi R. Frank G. Grossi G. High concentrations of catecholamines in human hypothalamic-hypophysial blood J Clin Invest 83 1989 2079
81. Petraglia F. Berhasconi S. lughetti L. Naloxone-induced luteinizing hormone secretion in normal, precocious, and delayed puberty J Clin Endocrinol Metab 63 1986 1112
82. Petraglia F. Frank G. Grossi G. Corticotropin-releasing factor decreases plasma luteinizing hormone levels in female rats by inhibiting gonadotropin-releasing hormone release into hypophyseal portal circulation Endocrinology 120 1987 1083
83. Pirke K.M. Schweiger U. Lemmel W. The influence of dieting on the menstrual cycle of healthy young women J Clin Endocrinol Metab 60 1985 1174
84. Plant T.M. Gay V.L. Marshall G.R. Puberty in monkeys is triggered by chemical stimulation of the hypothalamus Proc Natl Acad Sei USA 86 1989 2506
85. Powell K.E. Thompson P.D. Caspersen C.J. Physical activity and the incidence of coronary heart disease Annu Rev Public Health 8 1987 253
86. Quigley M.E. Sheehan K.L. Casper R.F. Evidence for an increased dopaminergic and opioid activity in patients with hypothalamic hypogonadotropic amenorrhea J Clin Endocrinol Metab 50 1980 949
87. Rabin D. Spitz I. Bercovici B. Isolated deficiency of follicle-stimulating hormones: Clinical and laboratory features NEJM 287 1972 1313
88. Rasmussen D.D. Gambacciani M. Swartz W. Pulsatile gonadotropin-releasing hormone release from the human mediobasal hypothalamus in vitro: Opiate receptor-mediated suppression Neuroendocrinology 49 1989 150
89. Rasmussen D.D. Liu J.H. Swartz W.H. Human fetal hypothalamic GnRH neurosecretion: Dopaminergic regulation in vitro Clin Endocrinol (Oxf) 25 1986 127
90. Rasmussen D.D. Liu J.H. Wolf P.L. Endogenous opioid regulation of gonadotropin-releasing hormone release from the human fetal hypothalamus in vitro J Clin Endocrinol Metab 57 1983 881
91. Reame N.E. Sauder S.E. Case G.D. Pulsatile gonadotropin secretion in women with hypothalamic amenorrhea: Evidence that reduced frequency of gonadotropinreleasing hormone secretion is the mechanism of persistent anovulation J Clin Endocrinol Metab 61 1985 851
92. Reifenstein E.C. Jr. Psychogenic or ‘hypothalamic’ amenorrhea Med Clin North Am 30 1946 1103
93. Reyes R.I. Boroditsky R.S. Winter J.S.D. Studies on human sexual development. II: Fetal and maternal serum gonadotropin and sex steroid concentrations J Clin Endocrinol Metab 38 1974 612
94. Ronkainen H. Pakarinen A. Kirkinen P. Physical exercise-induced changes and season-associated differences in the pituitary-ovarian function of runners and joggers J Clin Endocrinol Metab 60 1985 416
95. Ronnekleiv O.K. Adelman J.P. Weber E. Immunohistochemical demonstration of pro-GnRH and GnRH in the preoptic-basal hypothalamus of the primate Neuroendocrinology 45 1987 518
96. Ronnekleiv O.K. Naylor B.R. Bond C.T. Combined immunohistochemistry for gonadotropin-releasing hormone (GnRH) and pro-GnRH, and in situ hybridization for GnRH messenger ribonucleic acid in rat brain Mol Cell Endocrinol 3 1989 363
97. Ronnekleiv O.K. Resko J.A. Ontogeny of gonadotropin-releasing hormone-containing neurons in early fetal development of rhesus macaques Endocrinology 126 1990 498
98. Ross J.L. Loriux D.L. Cutler G.B. Developmental changes in neuroendocrine regulation of gonadotropin secretion in gonadal dysgenesis J Clin Endocrinol Metab 57 1983 288
99. Rossmanith W.G. Swartz W.H. Tueros V.S. Pulsatile GnRH-stimulated LH release from the human fetal pituitary in vitro: Sex-associated differences Clin Endocrinol 33 1990 719
100. Rupprecht R. Lesch L.-P. Müller U. Blunted adrenocorticotropin but normal β-endorphin release after human corticotropin-releasing hormone administration in depression J Clin Endocrinol Metab 69 1989 600
101. Sanborn C.F. Martin B.J. Wagner W.W. Is athletic amenorrhea specific to runners? Am J Obstet Gynecol 143 1982 859
102. Schwanzel-Fukuda M. Bick D. Pfaff D.W. Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome Mol Brain Res 6 1989 311
103. Schwanzel-Fukuda M. Pfaff D.W. Origin of luteinizing hormone-releasing hormone neurons Nature 338 1989 161
104. Schwartz B. Cumming D.C. Riordan E. Exercise-associated amenorrhea: A distinct entity? Am J Obstet Gynecol 141 1981 662
105. Seeburg P.H. Adelman J.P. Characterization of cDNA for precursor of human luteinizing hormone releasing hormone Nature 311 1984 666
106. Seeburg P.H. Mason A.J. Stewart T.A. The mammalian GnRH gene and its pivotal role in reproduction Recent Prog Horm Res 43 1987 69
107. Silverman A.-J. Jhamandas J. Renaud L.P. Localization of luteinizing hormonereleasing hormone (LHRH) neurons that project to the median eminence J Neurosci 7 1987 2312
108. Snow R.C. Barbieri R.L. Frisch R.E. Estrogen 2-hydroxylase oxidation and menstrual function among elite oarswomen J Clin Endocrinol Metab 69 1989 369
109. Sotsky M.J. Shilo S. Shamoon H. Regulation of counterregulatory hormone secretion in man during exercise and hypoglycemia J Clin Endocrinol Metab 68 1989 9
110. Spitz I.M. Diamant Y. Rosen E. Isolated gonadotropin deficiency: A heterogenous syndrome NEJM 290 1974 10
111. Standish L.J. Adams L.A. Vician L. Neuroanatomical localization of cells containing gonadotropin-releasing hormone messenger ribonucleic acid in the primate brain by in situ hybridization histochemistry Mol Cell Endocrinol 1 1987 371
112. Strassman R.J. Appenzeller O. Lewy A.J. Increase in plasma melatonin, β-endorphin, and cortisol after a 28.5-mile mountain race: Relationship to performance and lack of effect of naltrexone J Clin Endocrinol Metab 69 1989 540
113. Strauss J.H. Yen S.S.C. Benirschke K. Hypothalamic hypopituitarism in an adolescent girl: Assessment by a direct functional test of the adenohypophysis J Clin Endocrinol Metab 39 1974 639
114. Suh B.Y. Liu J.H. Berga S.L. Hypercortisolism in patients with functional hypothalamic-amenorrhea J Clin Endocrinol Metab 66 1988 733
115. Sutherland W.H.F. Woodhouse S.P. Physical activity and plasma lipoprotein lipid concentrations in men Atherosclerosis 37 1980 285
116. Symington T. Duguid W.P. Davidson J.N. Effect of exogenous corticotropin on histochemical pattern of human adrenal cortex and comparison with changes during stress J Clin Endocrinol Metab 16 1956 580
117. Theron J.J. Oosthuizen J.M.C. Routenbach M.M. Effect of physical exercise on plasma melatonin levels in normal volunteers S Afr Med J 66 1984 838
118. Van der Walt L.A. Wilmsen E.N. Jenkins T. Unusual sex hormone patterns among desert-dwelling hunter-gatherers J Clin Endocrinol Metab 46 1978 658
119. Veldhuis J.D. Evans W.S. Demers L.M. Altered neuroendocrine regulation of gonadotropin secretion in women distance runners J Clin Endocrinol Metab 61 1985 557
120. Vigersky R.A. Andersen A.E. Thompson R.H. Hypothalamic dysfunction in secondary amenorrhea associated with simple weight loss NEJM 297 1977 1141
121. Villanueva A.L. Schlosser C. Hopper B. Increased cortisol production in women runners J Clin Endocrinol Metab 63 1986 133
122. Weinberg U. Weitzkman E.D. Fukushima D.K. Melatonin does not suppress the pituitary luteinizing hormone response to LH-RH in man J Clin Endocrinol Metab 51 1980 161
123. Weitzman E.D. Biologic rhythms and hormone secretion patterns Krieger D.T. Hughes J.C. Neuroendocrinology 1980 Sinauer Associates Sunderland 85
124. Whitcomb R.W. Crowley W.F. Jr. Clinical review 4: Diagnosis and treatment of isolated gonadotropin-releasing hormone deficiency in men J Clin Endocrinol Metab 70 1990 3
125. Wiemann J.N. Clifton D.K. Steiner R.A. Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat Endocrinology 124 1989 1760
126. Wildt L. Leyendecker G. Induction of ovulation by the chronic administration of naltrexone in hypothalamic amenorrhea J Clin Endocrinol Metab 64 1987 1334
127. Wildt L. Marshall G.R. Knobil E. Experimental induction of puberty in the infantile female rhesus monkey Science 207 1980 1373
128. Williams C.L. Nishihara M. Thalabard J.-C. Corticotropin-releasing factor and gonadotropin-releasing hormone pulse generator activity in the rhesus monkey Neuroendocrinology 52 1990 133
129. Williams P.T. Krauss R.M. Wood P.D. Lipoprotein subfractions of runners and sedentary men Metabolism 35 1986 45
130. Yeh J. Rebar R.W. Liu J.H. Pituitary function in isolated gonadotrophin deficiency Clin Endocrinol (Oxf) 31 1989 375
131. Yen S.S.C. Rebar R.W. Endocrine rhythms in gonadotropins and ovarian steroids with reference to reproductive processes Krieger D.T. Endocrine Rhythms 1979 New York Raven Press 259
132. Yen S.S.C. Rebar R. Vandenberg G. Pituitary gonadotrophin responsiveness to synthetic LRF in subjects with normal and abnormal hypothalamic-pituitary-gonadal axis J Reprod Fertil 20 1973 137
133. Yen S.S.C. Rebar R. Vandenberg G. Hypothalamic amenorrhea and hypogonadotropism: Responses to synthetic LRF J Clin Endocrinol Metab 36 1973 811
134. Yen S.S.C. Reproductive strategy in women: Neuroendocrine basis of endogenous contraception Roland R. Neuroendocrinology of Reproduction 1988 Excerpta Medica Amsterdam 231