Mice lacking the MHC class II-associated invariant chain

Cell

Volumn 72, Issue 4, 1993, Pages 635-648

  Viville, Stéphane ^a,b   Neefjes, Jacques ^c   Lotteau, Vincent ^d   Dierich, Andrée ^a,b   Lemeur, Marianne ^a,b   Ploegh, Hidde ^c   Benoist, Christophe ^a,b   Mathis, Diane ^a,b  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b INSERM   (France)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; CELL MUTANT; CONFORMATIONAL TRANSITION; CYTOFLUOROMETRY; GENE EXPRESSION; GENE MUTATION; HELPER CELL; IMMUNOHISTOLOGY; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTIGEN-PRESENTING CELLS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNITY; MICE; MICE, MUTANT STRAINS; MUTAGENESIS, INSERTIONAL; PROTEIN CONFORMATION; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

ANIMALIA;

EID: 0027536939     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90081-Z     Document Type: Article

References (72)

1. Mechanisms influencing the immunodominance of T cell determinants
2. Invariant chain can function as a chaperon protein for class II major histocompatibility complex molecules
3. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
4. Characterization of cell lines expressing mutant I-Ab and I-Ak molecules allows the definition of distinct serologic epitopes on Aa and Ab polypeptides
5. Correlation between invariant chain expression level and capability to present antigen to MHC class II-restricted T cells
6. A shared alloantigenic determinant on la antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication
7. b antigen
8. Antigen presentation: structural themes and functional variations
9. The cell biology of antigen processing and presentation
10. Class II-restricted presentation of an endogenously derived immunodominant T cell determinant of hen egg lysozyme
11. Cytotoxic T cell recognition of an endogenous class I HLA peptide presented by a class II HLA molecule
12. Implication of the invariant γ-chain on the intracellular transport of class II histocompatibility antigens
13. Mice lacking MHC class II molecules
14. Chemistry and functional role of the invariant chain
15. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes
16. Superantigens interact with MHC class II molecules outside of the antigen groove
17. β11 T cells cosegregate with mammary tumour virus genomes
18. An hypothesis on the binding of an amphipathic, α helical sequence in li to the desetope of class II antigens
19. Cell surface display of rat invariant γ chain: detection by monoclonal antibodies directed against a C terminal γ chain segment
20. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
21. Class II MHC-restricted T cell determinants processed from either endosomes or the cytosol show similar requirement for host protein transport but different kinetics of presentation
22. The function of the invariant chain in antigen presentation by MHC class II molecules
23. Isolation of twelve monoclonal antibodies against la and H2 antigens
24. Membrane cell permeabilisation with saponin and multiparametric analysis by flow cytometry
25. Monoclonal antibodies specific for la glycoproteins raised by immunization with activated T cells: possible role of T cell-bound la antigens as targets of immunoregulatory T cells
26. Human T cell response to the surface antigen of hepatitis B virus (HBsAg) endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen
27. Detection of a common polypeptide chain in I-A and I-E sub-region immunoprecipitates
28. Brefeldin A: insights into the control of membrane traffic and organelle structure
29. Structure function relationship among T-cell receptors specific for lysozyme peptides bound to AB or Abm-12 molecules
30. Molecules that modify antigen recognition
31. Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody
32. Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus
33. Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex AαAβ dimers from the endoplasmic reticulum/cis-Golgi compartment
34. Correcting an immune-response deficiency by creating Ea gene transgenic mice
35. Fine specificity analysis with monoclonal antibodies of antigens controlled by the major histocompatibility complex and by the Qa/TL region in mice
36. k molecule
37. Intracellular transport of class II MHC molecules directed by invariant chain
38. Antibodies to the Golgi complex and the endoplasmic reticulum
39. The class II-restricted presentation of endogenously synthesized ovalbumin displays clonal variation, requires endosomal/lysosomal processing, and is up regulated by heat shock
40. Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain
41. Processing of an endogenous protein can generate MHC class II-restricted T cell determinants distinct from those derived from exogenous antigen
42. Antigen presentation of hen egg-white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II-associated invariant chain
43. Intracellular transport of MHC class II molecules
44. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resjstant αβ heterodimers in endosomes
45. Class II MHC molecules can use the endogenous pathway of antigen presentation
46. Properties of monoclonal antibodies to mouse Ig allotype, H2 and la antigens
47. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and la antigens
48. Invariant chain influences the immunological recognition of MHC class II molecules
49. Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41
50. Clonal analysis of B and T cell responses to la antigens
51. Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain
52. T and B cell receptors discriminate major histocompatibility complex class II conformations influenced by the invariant chain
53. Processing by accessory cells for presentation to murine T cells of apamin, a disulfide-bonded 18 amino acid peptide
54. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides
55. Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding
56. Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules
57. A role for peptide in determining MHC class II structure
58. Mouse B lymphocyte specific endocytosis and recycling of MHC class II molecules
59. Invariant chain influences posttranslational processing of HLA-DR molecules
60. HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells
61. Efficient cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain
62. Antigen presentation to HLA class II-restricted measles virus specific T cell clones can occur in the absence of the invariant chain
63. The role of la-invariant chain complex in the posttranslational processing and transport of la and invariant chain glycoproteins
64. The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide
65. A role of la-associated invariant chains in antigen processing and presentation
66. Invariant chain: a regulator of antigen presentation
67. Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways
68. Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal
69. κα
70. MHC class II-restricted presentation of intracellular antigen
71. An endogenous retrovirus mediating deletion of αβ T cells?
72. Human major histocompatibility complex class II invariant chain is expressed on the cell surface