메뉴 건너뛰기




Volumn 3, Issue 2, 1993, Pages 226-231

Effects of DNA methylation on DNA-binding proteins and gene expression

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA METHYLTRANSFERASE; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR;

EID: 0027535235     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-437X(93)90027-M     Document Type: Article
Times cited : (625)

References (55)
  • 1
    • 0026708177 scopus 로고
    • Targeted Mutation of the DNA Methyltransferase Gene Results in Embryonic Lethality
    • of outstanding interest, A gene knockout that, unlike most, has a dramatic phenotype. DNA methylation appears to be essential for completion of embryogenesis.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li1    Bestor2    Jaenisch3
  • 3
    • 0023119242 scopus 로고
    • Temporal and Regional Changes in DNA Methylation in the Embryonic, Extraembryonic and Germ Cell Lineages during Mouse Embryo Development
    • (1987) Development , vol.99 , pp. 371-382
    • Monk1    Boubeuk2    Lehnert3
  • 4
    • 0025005442 scopus 로고
    • In Vivo Footprint and Methylation Analysis by PCR-aided Genomic Sequencing: Comparison of Active and Inactive X Chro mosomal DNA at the CpG Island and Promoter of Human PGK-1
    • (1990) Genes Dev , vol.4 , pp. 1277-1287
    • Pfeifer1    Tanguay2    Steigerwald3    Riggs4
  • 6
    • 0026603943 scopus 로고
    • X-chromosome Inactivation and Cell Memory
    • of special interest, Stimulating review dealing with DNA methylation as one of a number of possible mechanisms of cell memory.
    • (1992) Trends Genet , vol.8 , pp. 169-174
    • Riggs1    Pfeifer2
  • 7
    • 0023274924 scopus 로고
    • Maternal Inhibition of Hepatitis B Surface Antigen Gene Expression in Transgenc Mice Correlates with de novo Methylation
    • (1987) Nature , vol.329 , pp. 454-456
    • Hadchouel1    Farza2    Simon3    Tiollais4    Pourcel5
  • 8
    • 0023614187 scopus 로고
    • Parental Legacy Determines Methylation and Expression of an Autosomal Transgene: A Molecular Mechanism for Parental Imprinting
    • (1987) Cell , vol.50 , pp. 719-727
    • Swain1    Stewart2    Leder3
  • 9
    • 0026781474 scopus 로고
    • Parental Imprinting: Potentially Active Chromatin of the Repressed Maternal Allele of the Mouse Insulin-like Growth Factor II Igf2 ) Gene
    • of special interst, First analysis of methylation and chromatin at a genuinely imprinted gene (i.e., not a transgene). The mechanism is not obvious as chromatin is apparently in a potentially active state, and the associated CpG island is not methylated. Indeed, the maternally derived allele is not fully repressed.
    • (1992) Genes Dev , vol.6 , pp. 1843-1856
    • Sasaki1    Jones2    Chaillet3    Ferguson-Smith4    Barton5    Reik6    Surani7
  • 10
    • 0024281345 scopus 로고
    • DNA Methylation and Gene Activity
    • (1988) Cell , vol.53 , pp. 3-4
    • Cedar1
  • 12
    • 0026555176 scopus 로고
    • Methylation of Discrete Sites Within the Enhancer Region Regulates the Activity of the Epstein-Barr Virus BamHI W Promoter in Burkitt Lymphoma Lines
    • (1992) J Virol , vol.66 , pp. 62-69
    • Jansson1    Masuccl2    Rymo3
  • 14
    • 0026316996 scopus 로고
    • Gene Silencing in Mammalian Cells by Direct Incorporation of Electroporated 5-Methyl-2′-Deoxycytidine 5′-Triphosphate
    • 5dCTP can be electroporated into cells and incorporated efficiently into DNA at replication.
    • (1991) Somat Cell Mol Genet , vol.17 , pp. 543-550
    • Nyce1
  • 15
    • 0026332115 scopus 로고
    • Gene Silencing in Mammalian Cells by Uptake of 5-Methyl Deoxycytidine-5′-Triphosphate
    • 5dCTP into cells is increased loss of gene function, presumably due to methylation of CpG islands.
    • (1991) Somat Cell Mol Genet , vol.17 , pp. 537-542
    • Holliday1    Ho2
  • 16
    • 0025119812 scopus 로고
    • Polymerase Chain Reaction-aided Genomic Sequencing of an X Chromosome-linked CpG Island: Methylation Pat terns Suggest Clonal Inheritance, CpG Site Autonomy, and an Explanation of Activity State Stability
    • 2nd edn
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8252-8256
    • Pfeifer1    Steigerwald2    Hansen3    Gartler4    Riggs5
  • 17
    • 0344599272 scopus 로고
    • Genomic Sequencing Reveals a Positive Correlation Between the Kinetics of Strand-Specific DNA Demethylation of the Overlapping Estradiol/Glucocorticoid-receptor Binding Sites and the Rate of Avian Vitellogenin mRNA Synthesis
    • 2nd edn
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 7167-7171
    • Saluz1    Jiricny2    Jost3
  • 20
    • 0025816339 scopus 로고
    • Analysis of CpG Methylation and Genomic Footprinting at the Tyrosine Aminotransferase gene: DNA Methylation Alone is not Sufficient to Prevent Protein Binding in Vivo
    • (1991) EMBO J , vol.10 , pp. 2559-2567
    • Weih1    Nitsch2    Reik3    Schutz4    Becker5
  • 22
    • 0026734647 scopus 로고
    • Overlapping and CpG Methylation-sensitive Protein-DNA Interactions at the Histone H4 Transcriptional Cell Cy cle Domain: Distinctions Between Two Human H4 Gene Promoters
    • (1992) Mol Cell Biol , vol.12 , pp. 3273-3287
    • Van Wijnen1    Van-Den-Ent2    Lian3    Stein4    Stein5
  • 23
  • 25
    • 0025975985 scopus 로고
    • DNA Methylation Inhibits Transcription Indirectly Via a Methyl-CpG Binding Protein
    • (1991) Cell , vol.64 , pp. 1123-1134
    • Boyes1    Bird2
  • 26
    • 0026583975 scopus 로고
    • Repression of Genes by DNA Methylation Depends on CpG Density and Promoter Strength: Evidence for Involvement of a Methyl-CpG Binding Protein
    • of special interest, Sets out the major parameters that determine the effect of DNA methylation on gene expression: regional location of methylation (established by other researchers); density of methylation; and strength of the promoter. Site-specific methylation at key CpGs may be less important than previously thought.
    • (1992) EMBO J , vol.11 , pp. 327-333
    • Boyes1    Bird2
  • 27
    • 0026747761 scopus 로고
    • Purification, Sequence, and Cellular Localization of a Novel Chromosomal Protein that Binds to Methylated DNA
    • of outstanding interest, Isolation of a protein that can bind to a single methyl-CpG pair. The protein, MeCP2, is found to be concentrated in the satellite DNA containing centromeric heterochromatin of mouse chromosomes.
    • (1992) Cell , vol.69 , pp. 905-914
    • Lewis1    Meehan2    Henzel3    Maurer-Fogy4    Jeppesen5    Klein6    Bird7
  • 28
    • 0026658662 scopus 로고
    • Characterization of MeCP2, a Vertebrate DNA Binding Protein with Affinity for Methylated DNA
    • (1992) Nucleic Acids Res , vol.20 , pp. 5085-5092
    • Meehan1    Lewis2    Bird3
  • 29
    • 0026653420 scopus 로고
    • The Essentials of DNA Methylation
    • (1992) Cell , vol.70 , pp. 5-8
    • Bird1
  • 30
    • 0026507505 scopus 로고
    • CpG Methylated Minichromosomes Become Inaccessible for V D)J Recombination After Undergoing Replication
    • of special interest, Evidence that the chromatin structure of methylated DNA changes at replication. DNA becomes more resistant to nucleases and is no longer able to rearrange. The relevance to inimunoglobulin gene rearrangement in vivo is uncertain as yet.
    • (1992) EMBO J , vol.11 , pp. 315-325
    • Hsieh1    Lieber2
  • 32
    • 0026026708 scopus 로고
    • An Avian 40 KDa Nucleoprotein Binds Preferentially to a Promoter Sequence Containing One Single Pair of Methylated CpG
    • (1991) Nucleic Acicds Res , vol.19 , pp. 1029-1034
    • Pawlak1    Bryans2    Jost3
  • 33
    • 0026005763 scopus 로고
    • Estradiol Down Regulates the Binding Activity of an Avian Vitellogenin Gene Repressor MDBP-2) and Triggers a Gradual Demethylation of the mCpG Pair of its DNA Binding Site
    • (1991) Nucleic Acids Res , vol.19 , pp. 5771-5775
    • Jost1    Saluz2    Pawlak3
  • 34
    • 0026668770 scopus 로고
    • The Repressor MDBP-2 is a Member of the Histone H 1 Family that Binds Preferentially in Vitro and in Vivo to Methylated Nonspecific DNA Sequences
    • 2nd edn
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9499-9503
    • Jost1    Hofsteenge2
  • 35
    • 0025744289 scopus 로고
    • The Combination of DNA Methylation and H1 Histone Binding Inhibits the Action of a Restriction Nuclease on Plasmid DNA
    • (1992) J Biol Gem , vol.266 , pp. 8619-8625
    • Higurashi1    Cole2
  • 37
    • 0023387702 scopus 로고
    • Site Specific Demethylation in the Promoter of Human Gamma-Globin Gene Does Not Alleviate Methylation Mediated Suppression
    • (1987) EMBO J , vol.6 , pp. 2329-2335
    • Murray1    Grosveld2
  • 38
    • 0026505117 scopus 로고
    • The Involvement of Demethylation in the Myeloid-specific Function of the Mouse M Lysozyme Gene Downstream Enhancer
    • of special interest, A study of the effects of DNA methylation on enhancer function. Argues for direct effects of methylation at specific CpGs on enhancer-binding proteins.
    • (1992) Nucleic Acid; Res , vol.20 , pp. 1925-1932
    • Klages1    Mollers2    Renkawitz3
  • 39
    • 0025836937 scopus 로고
    • DNA Hypomethylation and Germ Cell specific Expression of Testis-specific H2B Histone Gene
    • of outstanding interest, Thorough analysis of a small gene whose methylation level changes with expression. Balanced discussion of the relative importance of direct and indirect repression mechanisms.
    • (1991) J Biol Chem , vol.266 , pp. 20504-20511
    • Choi1    Chae2
  • 40
    • 0025294471 scopus 로고
    • CpG Methylation Inhibits Proenkephalin Gene Expression and Binding of the Transcription Factor AP-2
    • (1990) Nucleic Acids Res , vol.18 , pp. 3975-3982
    • Comb1    Goodman2
  • 41
    • 0025829169 scopus 로고
    • Association of Myn, the Murine Homolog of max, with c-myc Stimulates Methylation-sensitive DNA Binding and ras Cotransformation
    • (1991) Cell , vol.65 , pp. 395-407
    • Prendergast1    Lawe2    Ziff3
  • 42
    • 0024673303 scopus 로고
    • CpG Methylation of the CAMP-responsive Enhancer/Promoter Sequence TGAC-GTCA Abolishes Specific Factor Binding as Well as Transcriptional Activation
    • (1989) Genes Dev , vol.3 , pp. 612-619
    • Iguchi-Ariga1    Schaffner2
  • 43
    • 0026033073 scopus 로고
    • Binding of the Transcription Factor EBP80 Mediates the Methylation Response of an Intracisternal A-Particle Long Terminal Repeat Promoter
    • (1991) Mol Cell Blol , vol.11 , pp. 117-125
    • Faizon1    Kuff2
  • 45
    • 0026198118 scopus 로고
    • CpG Methylation Inhibits Binding of Several Sequence-specific DNA-binding Proteins from Pea, Wheat, Soybean and Cauliflower
    • (1991) Plant Mol Biol , vol.17 , pp. 111-123
    • Inamdar1    Ehruch2    Ehrlich3
  • 46
    • 0024081657 scopus 로고
    • Cytosine Methylation Prevents Binding to DNA of a HeLa Cell Transcription Factor Required for Optimal Expression of the Adenovirus Major Late Promoter
    • (1988) Genes Dev , vol.2 , pp. 1136-1143
    • Watt1    Molloy2
  • 48
    • 0024830846 scopus 로고
    • Cytosine Methylation in CTF and Spl Recognition Sites of an HSV tk Promoter: Effects on Transcription in Vivo and on Factor Binding in Vitro
    • (1989) Nucleic Acids Res , vol.17 , pp. 10179-10190
    • Ben-Hattar1    Beard2    Jiricny3
  • 49
    • 0026767079 scopus 로고
    • A Broad Bean cDNA Clone Encoding a DNA-Binding Protein Resembling Mammalian CREB in its Sequence Specificity and DNA Methylation Sensitivity
    • (1992) Gene , vol.117 , pp. 169-178
    • Ehrlich1    Cary2    Ehruch3
  • 50
    • 0024083068 scopus 로고
    • Sp1 Transcription Factor Binds DNA and Activates Transcription Even When the Binding Site is CpG Methylated
    • (1988) Genes Dev , vol.2 , pp. 1127-1135
    • Holler1    Westin2    Jiricny3    Schaffner4
  • 52
    • 0026594637 scopus 로고
    • Isolation and Characterization of Nuclear Proteins that Bind to T Cell Receptor V Beta Decamer Motif
    • (1992) J Immunol , vol.148 , pp. 1906-1912
    • Lee1    Chung2    Liou3    Wu4    Li5    Hsueh6    Lai7
  • 53
    • 0024342686 scopus 로고
    • Identification of a Mammalian Protein that Binds Specifically to DNA Containing Methylated CpGs
    • (1989) Cell , vol.58 , pp. 499-507
    • Meehan1    Lewis2    McKay3    Kleiner4    Bird5
  • 55
    • 0025484162 scopus 로고
    • Highly Repeated Sites in the Apolipoprotein a) Gene Recognized by Methylated DNABinding Protein, a Sequence-Specific DNA-Binding Protein
    • (1990) Mol Cell Biol , vol.10 , pp. 4957-4960
    • Ehrlich1    Ehrlich2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.