-
1
-
-
0026708177
-
Targeted Mutation of the DNA Methyltransferase Gene Results in Embryonic Lethality
-
of outstanding interest, A gene knockout that, unlike most, has a dramatic phenotype. DNA methylation appears to be essential for completion of embryogenesis.
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li1
Bestor2
Jaenisch3
-
3
-
-
0023119242
-
Temporal and Regional Changes in DNA Methylation in the Embryonic, Extraembryonic and Germ Cell Lineages during Mouse Embryo Development
-
(1987)
Development
, vol.99
, pp. 371-382
-
-
Monk1
Boubeuk2
Lehnert3
-
4
-
-
0025005442
-
In Vivo Footprint and Methylation Analysis by PCR-aided Genomic Sequencing: Comparison of Active and Inactive X Chro mosomal DNA at the CpG Island and Promoter of Human PGK-1
-
(1990)
Genes Dev
, vol.4
, pp. 1277-1287
-
-
Pfeifer1
Tanguay2
Steigerwald3
Riggs4
-
6
-
-
0026603943
-
X-chromosome Inactivation and Cell Memory
-
of special interest, Stimulating review dealing with DNA methylation as one of a number of possible mechanisms of cell memory.
-
(1992)
Trends Genet
, vol.8
, pp. 169-174
-
-
Riggs1
Pfeifer2
-
8
-
-
0023614187
-
Parental Legacy Determines Methylation and Expression of an Autosomal Transgene: A Molecular Mechanism for Parental Imprinting
-
(1987)
Cell
, vol.50
, pp. 719-727
-
-
Swain1
Stewart2
Leder3
-
9
-
-
0026781474
-
Parental Imprinting: Potentially Active Chromatin of the Repressed Maternal Allele of the Mouse Insulin-like Growth Factor II Igf2 ) Gene
-
of special interst, First analysis of methylation and chromatin at a genuinely imprinted gene (i.e., not a transgene). The mechanism is not obvious as chromatin is apparently in a potentially active state, and the associated CpG island is not methylated. Indeed, the maternally derived allele is not fully repressed.
-
(1992)
Genes Dev
, vol.6
, pp. 1843-1856
-
-
Sasaki1
Jones2
Chaillet3
Ferguson-Smith4
Barton5
Reik6
Surani7
-
10
-
-
0024281345
-
DNA Methylation and Gene Activity
-
(1988)
Cell
, vol.53
, pp. 3-4
-
-
Cedar1
-
12
-
-
0026555176
-
Methylation of Discrete Sites Within the Enhancer Region Regulates the Activity of the Epstein-Barr Virus BamHI W Promoter in Burkitt Lymphoma Lines
-
(1992)
J Virol
, vol.66
, pp. 62-69
-
-
Jansson1
Masuccl2
Rymo3
-
14
-
-
0026316996
-
Gene Silencing in Mammalian Cells by Direct Incorporation of Electroporated 5-Methyl-2′-Deoxycytidine 5′-Triphosphate
-
5dCTP can be electroporated into cells and incorporated efficiently into DNA at replication.
-
(1991)
Somat Cell Mol Genet
, vol.17
, pp. 543-550
-
-
Nyce1
-
15
-
-
0026332115
-
Gene Silencing in Mammalian Cells by Uptake of 5-Methyl Deoxycytidine-5′-Triphosphate
-
5dCTP into cells is increased loss of gene function, presumably due to methylation of CpG islands.
-
(1991)
Somat Cell Mol Genet
, vol.17
, pp. 537-542
-
-
Holliday1
Ho2
-
16
-
-
0025119812
-
Polymerase Chain Reaction-aided Genomic Sequencing of an X Chromosome-linked CpG Island: Methylation Pat terns Suggest Clonal Inheritance, CpG Site Autonomy, and an Explanation of Activity State Stability
-
2nd edn
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 8252-8256
-
-
Pfeifer1
Steigerwald2
Hansen3
Gartler4
Riggs5
-
17
-
-
0344599272
-
Genomic Sequencing Reveals a Positive Correlation Between the Kinetics of Strand-Specific DNA Demethylation of the Overlapping Estradiol/Glucocorticoid-receptor Binding Sites and the Rate of Avian Vitellogenin mRNA Synthesis
-
2nd edn
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 7167-7171
-
-
Saluz1
Jiricny2
Jost3
-
20
-
-
0025816339
-
Analysis of CpG Methylation and Genomic Footprinting at the Tyrosine Aminotransferase gene: DNA Methylation Alone is not Sufficient to Prevent Protein Binding in Vivo
-
(1991)
EMBO J
, vol.10
, pp. 2559-2567
-
-
Weih1
Nitsch2
Reik3
Schutz4
Becker5
-
22
-
-
0026734647
-
Overlapping and CpG Methylation-sensitive Protein-DNA Interactions at the Histone H4 Transcriptional Cell Cy cle Domain: Distinctions Between Two Human H4 Gene Promoters
-
(1992)
Mol Cell Biol
, vol.12
, pp. 3273-3287
-
-
Van Wijnen1
Van-Den-Ent2
Lian3
Stein4
Stein5
-
25
-
-
0025975985
-
DNA Methylation Inhibits Transcription Indirectly Via a Methyl-CpG Binding Protein
-
(1991)
Cell
, vol.64
, pp. 1123-1134
-
-
Boyes1
Bird2
-
26
-
-
0026583975
-
Repression of Genes by DNA Methylation Depends on CpG Density and Promoter Strength: Evidence for Involvement of a Methyl-CpG Binding Protein
-
of special interest, Sets out the major parameters that determine the effect of DNA methylation on gene expression: regional location of methylation (established by other researchers); density of methylation; and strength of the promoter. Site-specific methylation at key CpGs may be less important than previously thought.
-
(1992)
EMBO J
, vol.11
, pp. 327-333
-
-
Boyes1
Bird2
-
27
-
-
0026747761
-
Purification, Sequence, and Cellular Localization of a Novel Chromosomal Protein that Binds to Methylated DNA
-
of outstanding interest, Isolation of a protein that can bind to a single methyl-CpG pair. The protein, MeCP2, is found to be concentrated in the satellite DNA containing centromeric heterochromatin of mouse chromosomes.
-
(1992)
Cell
, vol.69
, pp. 905-914
-
-
Lewis1
Meehan2
Henzel3
Maurer-Fogy4
Jeppesen5
Klein6
Bird7
-
29
-
-
0026653420
-
The Essentials of DNA Methylation
-
(1992)
Cell
, vol.70
, pp. 5-8
-
-
Bird1
-
30
-
-
0026507505
-
CpG Methylated Minichromosomes Become Inaccessible for V D)J Recombination After Undergoing Replication
-
of special interest, Evidence that the chromatin structure of methylated DNA changes at replication. DNA becomes more resistant to nucleases and is no longer able to rearrange. The relevance to inimunoglobulin gene rearrangement in vivo is uncertain as yet.
-
(1992)
EMBO J
, vol.11
, pp. 315-325
-
-
Hsieh1
Lieber2
-
32
-
-
0026026708
-
An Avian 40 KDa Nucleoprotein Binds Preferentially to a Promoter Sequence Containing One Single Pair of Methylated CpG
-
(1991)
Nucleic Acicds Res
, vol.19
, pp. 1029-1034
-
-
Pawlak1
Bryans2
Jost3
-
33
-
-
0026005763
-
Estradiol Down Regulates the Binding Activity of an Avian Vitellogenin Gene Repressor MDBP-2) and Triggers a Gradual Demethylation of the mCpG Pair of its DNA Binding Site
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 5771-5775
-
-
Jost1
Saluz2
Pawlak3
-
34
-
-
0026668770
-
The Repressor MDBP-2 is a Member of the Histone H 1 Family that Binds Preferentially in Vitro and in Vivo to Methylated Nonspecific DNA Sequences
-
2nd edn
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9499-9503
-
-
Jost1
Hofsteenge2
-
35
-
-
0025744289
-
The Combination of DNA Methylation and H1 Histone Binding Inhibits the Action of a Restriction Nuclease on Plasmid DNA
-
(1992)
J Biol Gem
, vol.266
, pp. 8619-8625
-
-
Higurashi1
Cole2
-
37
-
-
0023387702
-
Site Specific Demethylation in the Promoter of Human Gamma-Globin Gene Does Not Alleviate Methylation Mediated Suppression
-
(1987)
EMBO J
, vol.6
, pp. 2329-2335
-
-
Murray1
Grosveld2
-
38
-
-
0026505117
-
The Involvement of Demethylation in the Myeloid-specific Function of the Mouse M Lysozyme Gene Downstream Enhancer
-
of special interest, A study of the effects of DNA methylation on enhancer function. Argues for direct effects of methylation at specific CpGs on enhancer-binding proteins.
-
(1992)
Nucleic Acid; Res
, vol.20
, pp. 1925-1932
-
-
Klages1
Mollers2
Renkawitz3
-
39
-
-
0025836937
-
DNA Hypomethylation and Germ Cell specific Expression of Testis-specific H2B Histone Gene
-
of outstanding interest, Thorough analysis of a small gene whose methylation level changes with expression. Balanced discussion of the relative importance of direct and indirect repression mechanisms.
-
(1991)
J Biol Chem
, vol.266
, pp. 20504-20511
-
-
Choi1
Chae2
-
40
-
-
0025294471
-
CpG Methylation Inhibits Proenkephalin Gene Expression and Binding of the Transcription Factor AP-2
-
(1990)
Nucleic Acids Res
, vol.18
, pp. 3975-3982
-
-
Comb1
Goodman2
-
41
-
-
0025829169
-
Association of Myn, the Murine Homolog of max, with c-myc Stimulates Methylation-sensitive DNA Binding and ras Cotransformation
-
(1991)
Cell
, vol.65
, pp. 395-407
-
-
Prendergast1
Lawe2
Ziff3
-
42
-
-
0024673303
-
CpG Methylation of the CAMP-responsive Enhancer/Promoter Sequence TGAC-GTCA Abolishes Specific Factor Binding as Well as Transcriptional Activation
-
(1989)
Genes Dev
, vol.3
, pp. 612-619
-
-
Iguchi-Ariga1
Schaffner2
-
43
-
-
0026033073
-
Binding of the Transcription Factor EBP80 Mediates the Methylation Response of an Intracisternal A-Particle Long Terminal Repeat Promoter
-
(1991)
Mol Cell Blol
, vol.11
, pp. 117-125
-
-
Faizon1
Kuff2
-
45
-
-
0026198118
-
CpG Methylation Inhibits Binding of Several Sequence-specific DNA-binding Proteins from Pea, Wheat, Soybean and Cauliflower
-
(1991)
Plant Mol Biol
, vol.17
, pp. 111-123
-
-
Inamdar1
Ehruch2
Ehrlich3
-
46
-
-
0024081657
-
Cytosine Methylation Prevents Binding to DNA of a HeLa Cell Transcription Factor Required for Optimal Expression of the Adenovirus Major Late Promoter
-
(1988)
Genes Dev
, vol.2
, pp. 1136-1143
-
-
Watt1
Molloy2
-
48
-
-
0024830846
-
Cytosine Methylation in CTF and Spl Recognition Sites of an HSV tk Promoter: Effects on Transcription in Vivo and on Factor Binding in Vitro
-
(1989)
Nucleic Acids Res
, vol.17
, pp. 10179-10190
-
-
Ben-Hattar1
Beard2
Jiricny3
-
49
-
-
0026767079
-
A Broad Bean cDNA Clone Encoding a DNA-Binding Protein Resembling Mammalian CREB in its Sequence Specificity and DNA Methylation Sensitivity
-
(1992)
Gene
, vol.117
, pp. 169-178
-
-
Ehrlich1
Cary2
Ehruch3
-
55
-
-
0025484162
-
Highly Repeated Sites in the Apolipoprotein a) Gene Recognized by Methylated DNABinding Protein, a Sequence-Specific DNA-Binding Protein
-
(1990)
Mol Cell Biol
, vol.10
, pp. 4957-4960
-
-
Ehrlich1
Ehrlich2
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