Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

The Lancet

Volumn 341, Issue 8836, 1993, Pages 63-

  Bertilsson, L ^a   Dahl, M L ^a   Sjöqvist, F ^a   Åberg Wistedt, A ^b   Humble, M ^c   Johansson, I ^c   Lundqvist, Eva ^c   Ingelman Sundberg, M ^c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Department of Psychiatry Karolinksa Institute St Gorans Hospital ^*  (United Kingdom)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; CLOMIPRAMINE; DEBRISOQUINE; DESIPRAMINE; NEUROLEPTIC AGENT; NORTRIPTYLINE;

ADULT; CASE REPORT; DEPRESSION; DNA DETERMINATION; DRUG METABOLISM; DRUG RESPONSE; FEMALE; GENETIC ANALYSIS; HUMAN; HYDROXYLATION; LETTER; PRIORITY JOURNAL;

DEBRISOQUIN; FEMALE; HUMAN; HYDROXYLATION; METABOLIC DISEASES; NEUROTIC DISORDERS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SUPPORT, NON-U.S. GOV'T;

EID: 0027534276     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/0140-6736(93)92546-6     Document Type: Letter

References (9)

1. Pronounced differences between Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
2. Clinical significance of the sparteine/debrisoquine oxidation polymorphism
3. Genotyping of poor metabolizers of debrisoquine by allele-specific amplification
4. Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population
5. Clinical pharmacokinetics of clomipramine
6. Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortnptyline and other tricyclic antidepressants
7. Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression
8. Evolution of a highly polymorphic human cytochrome P450 gene cluster—CYP2D6