Steric inhibition of cytoplasmic dynein and kinesin motility by MAP2

Cell Motility and the Cytoskeleton

Volumn 24, Issue 1, 1993, Pages 1-16

  Lopez, Luis A ^a   Sheetz, Michael P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cytoplasmic dynein; kinesin; MAPs; microtubules; motility

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN; MICROTUBULE ASSOCIATED PROTEIN 2; TAU PROTEIN; TUBULIN;

ARTICLE; CELL MOTILITY; CELL POLARITY; CHICK EMBRYO; CYTOPLASM VESICLE; ENZYME ACTIVE SITE; ENZYME INHIBITION; INTRACELLULAR TRANSPORT; MICROTUBULE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING;

ANIMAL; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CATTLE; CYTOPLASM; DYNEIN ATPASE; ENDOPLASMIC RETICULUM; KINESIN; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MOVEMENT; ORGANELLES; PROTEIN CONFORMATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TAU PROTEINS;

EID: 0027533201     PISSN: 08861544     EISSN: 10970169     Source Type: Journal    
DOI: 10.1002/cm.970240102     Document Type: Article

References (62)

1. Polarity orientation of microtubules in hippocampal neurons: Uniformity in the axon and nonuniformity in the dendrite
2. Separation and characterization of microtubule proteins from calf brain
3. Bead movement by single kinesin molecules studied with optical tweezers
4. Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly in vitro
5. Dendrites of mitral cell neurons contain microtubules of opposite polarity
6. MAP2 is localized to the dendrites of hippocampal neurons which develop in culture
7. Differential subcellular localization of tubulin and the microtubule‐associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies
8. Immunofluorescence distribution of alpha tubulin, beta tubulin and microtubule‐associated protein 2 during in vitro maturation of cerebral granule cell neurons
9. Cultured cell extracts support organelle movement on microtubules in vitro
10. The microtubule‐dependent formation of a tubulovesicular network with characteristics of the ER from cultured cell extracts
11. Distribution of microtubule‐associated protein 2 in the nervous system of the rat studied by immunofluorescence
12. Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation
13. Nerve growth factor‐induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly‐promoting factors
14. Intracellular localization of MAP2‐related protein (O‐MAP) in prophase I and metaphase oocytes of Xenopus
15. Tracking kinesin‐driven movements with nanometre‐scale precision
16. Analysis of the microtubule‐binding domain of MAP‐2
17. The interaction of actin filaments with microtubules and microtubules associated proteins
18. Characterization of α2 β2 and α2 forms of kinesin
19. Polarity orientation of axoinal microtubules
20. Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration
21. Movement of microtubules by single kinesin molecules
22. Inhibition of kinesin‐driven microtubule motility by monoclonal antibodies to kinesin heavy chains
23. The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibrobalsts
24. Cleavage of structural proteins during the assembly of the bacteriophage T4
25. Extracellular matrix allows PC12 neurite elongation in the absence of microtubules
26. Microtubule associated protein MAP2 shares a microtubule binding motif with tau protein
27. Microtubule organization in dendrites and axons is determined by a short hydrophobic zipper in microtubule‐associated proteins MAP2 and tau
28. Tubulin assembly protein: Immunochemical and immunofluorescent studies on its function and distribution in microtubules and cultured cells
29. Identification of a microtubule‐based cytoplasmic motor in the nematode C. elegans
30. Microtubule‐associated proteins
31. Neuronal microdifferentiation. Cold Spring Harbor Symp
32. Immunohistochemical localization of microtubule‐associated proteins in the nervous system of the small intestine of guinea pig
33. Immunohistochemical localization of microtubule‐associated proteins 1A and 2 in the rat retina
34. Microtubule‐associated proteins
35. Non‐motor microtubule‐associated proteins
36. MAP 1C is a microtubule‐activated ATPase which translocates microtubules in vitro and has dynein‐like properties
37. Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin
38. Biochemical and immunological analyses of cytoskeletal domains of neurons
39. Microtubule‐associated proteins and microtubule‐based translocators have different binding sites on tubulin molecule
40. Mechanisms of intracellular organelle transport
41. Viewing single microtubules by video light microscopy
42. Dynein is the motor for retrograde axonal transport of organelles
43. Identification of globular mechanochemical beads of kinesin
44. The role of kinesin and other soluble factors in organelle movement along microtubules
45. Functions of microtubulebased motors
46. Cytoplasmic dynein is a minus‐end directed motor for membranous organelles
47. Myosin movement in vitro: A quantitative assay using oriented actin cables from nitella
48. Binding of microtubules to pituitary secretory granules and secretory granule membranes
49. Structure and composition of the cytoskeleton of nucleated erythrocytes. I. The presence of microtubule‐associated protein 2 in the marginal band
50. Purification and assay of microtubule‐associated proteins
51. Cyclic AMP dependent endogenous phosphorylation of a microtubule‐associated protein
52. Cytoplasmic dynein localizes to mitotic spindles and kinetochores
53. The role of microtubule‐associated protein in brain morphogenesis: A review
54. Microtubule‐based motor proteins
55. Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon
56. Structure and phosphorylation of microtubule‐associated protein 2 (MAP 2)
57. Microtubule‐associated protein 1C from brain is a twoheaded cytosolic dynein
58. Interaction between kinesin, microtubules, and microtubule‐associated protein 2
59. Electron microscopy of MAP 2 (microtubule‐associated protein 2)
60. A protein factor essential for microtubule assembly
61. High‐molecular‐weight microtubule‐associated proteins (MAPs): A ubiquitous family of cytoskeletal connecting links
62. Preparation of tubulin from brain