Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

Neuron

Volumn 10, Issue 2, 1993, Pages 137-149

  Ip, Nancy Y ^a   Stitt, Trevor N ^a   Tapley, Peter ^b   Klein, Rudiger ^b   Glass, David J ^a   Fandl, James ^a   Greene, Lloyd A ^c   Barbacid, Mariano ^b   Yancopoulos, George D ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^c Department of Pathology Center for Neurobiology Behavior College of Physicians ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED GROWTH FACTOR; LIGAND; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CELL STRAIN COS1; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

3T3 CELLS; ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; COMPARATIVE STUDY; ENZYME ACTIVATION; HUMAN; MEMBRANE PROTEINS; MICE; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; PC12 CELLS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASE; RATS; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TYROSINE;

EID: 0027528768     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/0896-6273(93)90306-C     Document Type: Article

References (44)

1. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB
2. Nerve growth factor has both mitogenic and anti mitogenic activity
3. Gene transfer and molecular cloning of the human NGF receptor
4. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
5. The trktyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
6. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor
7. TrkB mediates BDNF/NT-3 dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor
8. PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor
9. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
10. PC12 pheochromocytoma cells in neurobiological research
11. Expression of functional nerve growth factor receptors after gene transfer
12. High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
13. Identification and characterization of a novel member of the nerve growth factor/brain derived neurotrophic factor family
14. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary
15. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity
16. CNTF and LI F act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp 130
17. Nerve growth factor mediates signal transduction through Trk homodimer receptors
18. Molecular cloning of a human gene that is a member of the nerve growth factor family
19. Cloning and expression of a cDNA encoding a novel human neurotrophic factor
20. Tyrosine phosphorylation and tyrosine kinase activity of the trk protooncogene product induced by NGF
21. The rk proto-oncogene product: a signal transducing receptor for nerve growth factor
22. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development
23. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
24. The trk proto-oncogene encodes a receptor for nerve growth factor
25. The trkB tyrosine kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
26. The trkB tyrosine protein kinase is a receptor for neurotrophin-4
27. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
28. Molecular cloning and expression of brain-derived neurotrophic factor
29. The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines
30. Concentrationdependent regulation of neuronal gene expression by nerve growth factor
31. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
32. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
33. Molecular and biochemical characterization of the human trk protooncogene
34. Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development
35. trkB a neural receptor protein kinase: evidence for a full-length and two truncated receptors
36. K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophinmediated responses
37. Gene transfer and molecular cloning of the rat nerve growth factor receptor
38. Binding brain-derived neurotrophic factor to the nerve growth factor receptor
39. Primary structure and biological activity of a novel human neurotrophic factor
40. The quantitative bioassay of nerve growth factor: use of frozen ‘pri med’ PC12 pheoch romocytoma cells
41. Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms
42. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
43. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
44. The changing scene of neurotrophic factors