Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons

Epilepsy Research

Volumn 16, Issue 2, 1993, Pages 89-98

  Rock, David M ^a,b   Kelly, Kevin M ^c   Macdonald, Robert L ^c  

^a PFIZER INC   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Calcium currents; GABA; Gabapentin; Glycine; Investigational antiepileptic drug; N Methyl d aspartate; Repetitive firing; Single channel; Sodium action potentials; Voltage clamp

Indexed keywords

4 AMINOBUTYRIC ACID; ETHOSUXIMIDE; GABAPENTIN; GLUTAMINE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID; NIFEDIPINE; OMEGA CONOTOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; FETUS; MOUSE; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP;

ACETIC ACIDS; ACTION POTENTIALS; ANIMAL; ANTICONVULSANTS; CALCIUM CHANNELS; CELLS, CULTURED; CEREBRAL CORTEX; FETUS; GAMMA-AMINOBUTYRIC ACID; GLUTAMATES; GLUTAMIC ACID; GLYCINE; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; MICE; N-METHYLASPARTATE; NEURONS; NEURONS, AFFERENT; NODOSE GANGLION; RATS; SODIUM CHANNELS; SPINAL CORD; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPSES;

EID: 0027527142     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/0920-1211(93)90023-Z     Document Type: Article

References (29)

1. Gabapentin and convulsions provoked by excitatory amino acids
2. Indications for an involvement of the GABA-system in the mechanism of action of gabapentin
3. Gabapentin
4. Preclinical characterization of the anticonvulsant gabapentin
5. Gabapentin in the treatment of drug-resistant epileptic patients
6. Gabapentin
7. Gabapentin as an antiepileptic drug in man
8. Preclinical characterization of the anticonvulsant gabapentin
9. Gabapentin
10. Gabapentin: action on hippocampal slices of the rat and effects in human epileptics
11. Effect of gabapentin on complex partial seizure frequency
12. 3H]gabapentin to a novel site in rat brain: autoradiographic studies
13. Gabapentin does not affect NMDA receptor currents or voltage-dependent calcium currents in cultured rodent neurons
14. Comparison of gabapentin with other antiepileptic and GABAergic drugs
15. Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain
16. Principles of antiepileptic drug action
17. The anticonvulsant action of gabapentin involves the glycine/NMDA receptor
18. Inhibition by GABA, baclofen, and gabapentin of dopamine release from rabbit caudate nucleus: are there common or different sites of action?
19. Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds
20. Intensive monitoring and pharmacokinetic studies of gabapentin in patients with generalized spike-wave discharges
21. Gabapentin decreases monoamine release without affecting acetylcholine release in the brain
22. Potential antiepileptic drugs: gabapentin
23. Double-blind study of gabapentin in the treatment of partial seizures
24. 3H]gabapentin binding to a novel site in rat brain: homogenate binding studies
25. In vitro and in vivo electrophysiology effects of the anticonvulsant gabapentin
26. Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin
27. Multiple cellular actions of gabapentin
28. Effects of gabapentin on repetitive firing of action potentials and GABA responses of mouse central neurons in cell culture