Evaluation of a three‐exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals

Environmental and Molecular Mutagenesis

Volumn 21, Issue 2, 1993, Pages 160-179

  Shelby, M D ^a   Erexson, G L ^b   Hook, G J ^c   Tice, R R ^d  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b EHRT Inc ^*  (United States)

^c ILS   (United States)

^d ORAU   (United States)

Author keywords

carcinogens; coded chemicals; genotoxic chemicals; noncarcinogens

Indexed keywords

ASCORBIC ACID; CHEMICAL AGENT; EUGENOL; MANNITOL; MENTHOL; MITOMYCIN C; RESERPINE; SELENIUM; SULFAFURAZOLE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; MICRONUCLEUS TEST; MOUSE; MUTAGEN TESTING; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; BONE MARROW; CARCINOGENS; DRUG ADMINISTRATION SCHEDULE; LETHAL DOSE 50; MALE; MICE; MICRONUCLEUS TESTS; REPRODUCIBILITY OF RESULTS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027526525     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.2850210210     Document Type: Article

References (43)

1. Species‐specific response to the rodent carcinogens 1,2‐dimethylhydrazine and 1,2‐dibromo‐3‐chloropropane in rodent bone‐marrow micronucleus assays
2. Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U
3. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U
4. Classification according to chemical structure, mutagenicity to Salmonella, and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U
5. Benzene and the genotoxicity of its metabolites, II
6. Cytogenetic effect of trichloroethylene in the mouse as evaluated by the micronucleus test
7. A simplified protocol for the mouse bone marrow micronucleus assay
8. In vivo cytogenetic studies on mice exposed to Orange G, a food colourant
9. Micronucleus induction by azobenzene and 1,2‐dibromo‐3‐chloropropane
10. Relationship between experimental results in mammals and man: II
11. Target organs in chronic bioassays of 533 chemical carcinogens
12. Mutagenic effects of dimethyl terephthalate on mouse somatic cells in vivo
13. Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals
14. Chemicals associated with site‐specific neoplasia in 1394 long‐term carcinogenesis experiments in laboratory rodents
15. The micronucleus test as part of a short‐term mutagenicity test program for the prediction of carcinogenicity evaluated by 143 agents tested
16. Mutagenic and clastogenic potential of some antihypertensive drugs
17. Clastogen‐induced micronuclei in peripheral blood erythrocytes: The basis of an improved micronucleus test
18. Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes
19. The in vivo erythrocyte micronucleus test: Measurement at steady state increases assay efficiency and permits integration with toxicity studies
20. Negative evidence in vivo of DNA‐damaging, mutagenic and chromosomal effects of eugenol
21. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse marrow cells
22. The bone marrow clastogenicity of eight halogenated benzenes in male NMRI mice
23. In vitro genotoxicity of dimethyl terephalate
24. Corn oil and its minor constituents as inhibitors of DMBA‐induced chromosomal breaks in vivo
25. Comparison of single/multiple dose protocols using triethylenemelamine and procarbazine hydrochloride for the mouse bone marrow micronucleus test
26. The bone marrow micronucleus assay, rationale for a revised protocol
27. The persistence of micronuclei in peripheral blood erythrocytes: Detection of chronic chromosome breakage in mice
28. Mutagenic potential of a substituted urea herbicide; Monuron
29. The genetic toxicity of human carcinogens and its implications
30. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4‐aminobiphenyl, treosulphan, and melphalan
31. Detection of human carcinogens in the Salmonella and rodent bone‐marrow cytogenetics tests
32. Single versus multiple dosing in the micronucleus test: the summary of the fourth collaborative study by CSGMT/JEMS MMS
33. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays
34. A method for determining the maximum tolerated dose for acute in vivo cytogenetic studies
35. Effect of treatment protocol and sample time on frequencies of micronucleated cells in mouse bone marrow and peripheral blood
36. The induction of micronucleated polychromatic erythrocytes in mice using single and multiple treatments
37. Serial vs single dosing protocols for the rodent bone‐marrow micronucleus assay
38. Testing of sunset yellow and orange II for genotoxicity in different laboratory animal species
39. Study of artificial flavouring substance for mutagenicity in the Salmonella/microsome, BASC and micronucleus tests
40. Evaluation of eugenol for mutagenicity by the mouse micronucleus test
41. Studies on micronuclei time response and on the effects of multiple treatments of mutagens on induction of micronuclei
42. Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier results with 41 additional chemicals