The pharmacokinetics of methotrexate and its 7‐hydroxy metabolite in patients with rheumatoid arthritis.

British Journal of Clinical Pharmacology

Volumn 35, Issue 4, 1993, Pages 409-412

  Seideman, P ^a   Beck, O ^a   Eksborg, S ^a   Wennberg, M ^a  

^a DANDERYD HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYMETHOTREXATE; DRUG METABOLITE; METHOTREXATE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG URINE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADMINISTRATION, ORAL; AGED; ARTHRITIS, RHEUMATOID; COMPARATIVE STUDY; FEMALE; FOLIC ACID ANTAGONISTS; HUMAN; INJECTIONS, INTRAMUSCULAR; MALE; METHOTREXATE; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T;

EID: 0027526252     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1993.tb04158.x     Document Type: Article

References (24)

1. Pharmacokinetics of oral methotrexate in children
2. Trace analysis of methotrexate and 7‐hydroxymethotrexate in human plasma and urine by a novel h.p.l.c. method
3. Comparison of intravenous and oral high‐dose methotrexate in treatment of solid tumors
4. Liver damage due to methotrexate in patients with psoriasis
5. Methotrexate hepatotoxicity in psoriasis. Comparison of different dose regimens
6. Low‐dose methotrexate kinetics in arthritis
7. Disposition of intermediate dose methotrexate in children with acute lymphocytic leukemia
8. Pharmacokinetics of low‐dose methotrexate in rheumatoid arthritis (abstract)
9. Pharmacokinetics of low‐dose methotrexate in RA patients
10. Methotrexate in Reiter's disease
11. Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukemia
12. In vivo methotrexate kinetics and metabolism in human hematopoetic cells
13. Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment
14. Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low dose oral methotrexate therapy of children with acute lymphoblastic leukemia
15. Estimating the dimension of a model
16. Pharmacokinetic parameter estimates from several least squares procedures: Superiority of extended least squares
17. Clinical pharmacokinetics of methotrexate
18. Methotrexate pharmacokinetics in patients with rheumatoid arthritis
19. Methotrexate bioavailability after oral and intramuscular administration in children
20. Methotrexate in rheumatoid arthritis. Indications, contraindications, efficacy and safety
21. Clinical pharmacokinetics of methotrexate in children
22. Effect of route of administration and effusions on methotrexate pharmacokinetics
23. Randomized, double‐blind, placebo controlled trial of low‐dose pulse methotrexate in psoriatic arthritis