Analysis of 462 Transplantations from Unrelated Donors Facilitated by the National Marrow Donor Program

New England Journal of Medicine

Volumn 328, Issue 9, 1993, Pages 593-602

  Kernan, Nancy A ^a   Bartsch, Glenn ^b   Ash, Robert C ^d   Beatty, Patrick G ^e   Champlin, Richard ^f   Filipovich, Alexandra ^b   Gajewski, James ^g   Hansen, John A ^c   Henslee Downey, Jean ^h   McCullough, Jeffrey ^b   McGlave, Philip ^b   Perkins, Herbert A ⁱ   Phillips, Gordon L ^j   Sanders, Jean ^c   Stroncek, David ^b   Thomas, E Donnall ^c   Blume, Karl G ^k  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c FRED HUTCHINSON CANCER RESEARCH CENTER   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF KENTUCKY   (United States)

ⁱ Irwin Memorial Blood Center   (United States)

^j VANCOUVER GENERAL HOSPITAL   (Canada)

^k STANFORD UNIVERSITY MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; FEMALE; GRAFT VERSUS HOST REACTION; HIGH RISK POPULATION; HLA MATCHING; HUMAN; IMMUNE DEFICIENCY; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; POPULATION RESEARCH; PRIORITY JOURNAL; PROBABILITY; PROGNOSIS; STATISTICAL ANALYSIS; SURGICAL RISK; SURVIVAL RATE; UNITED STATES;

ADOLESCENT; ADULT; ANEMIA, APLASTIC; BONE MARROW TRANSPLANTATION; CAUSE OF DEATH; CHILD; DATA COLLECTION; FEMALE; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; HLA ANTIGENS; HUMAN; LEUKEMIA; MALE; MIDDLE AGE; ORGAN PROCUREMENT; SURVIVAL RATE; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS; UNITED STATES;

EID: 0027526116     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199303043280901     Document Type: Article

References (73)

1. Thomas ED Karnofsky memorial lecture: marrow transplantation for malignant diseases. J Clin Oncol 1983; 1:517-531
2. O'Reilly RJ Allogeneic bone marrow transplantation: current status and future directions. Blood 1983; 62:941-964
3. Bortin MM, Rimm AA Increasing utilization of bone marrow transplantation: II. Results of the 1985-1987 survey. Transplantation 1989; 48:453-458
4. Horowitz SD, Groshong T, Bach FH, Hong R Treatment of severe combined immunodeficiency with bone-marrow from an unrelated, mixed-leucocyte-culture-nonreactive donor. Lancet 1975; 2:431-433
5. O'Reilly RJ, Dupont B, Pahwa S, Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor. N Engl J Med 1977; 297:1311-1318
6. The Westminster Hospitals Bone-Marrow Transplant Team. Bone-marrow transplant from an unrelated donor for chronic granulomatous disease. Lancet 1977; 1:210-213
7. Speck B, Zwaan FE, van Rood JJ, Eernisse JG Allogeneic bone marrow transplantation in a patient with aplastic anemia using a phenotypically HL-A-identical unrelated donor. Transplantation 1973; 16:24-28
8. Lohrmann H-P, Dietrich M, Goldmann SF, Bone marrow transplantation for aplastic anaemia from a HL-A and MLC-identical unrelated donor. Blut 1975; 31:347-354
9. Hansen JA, Clift RA, Thomas ED, Buckner CD, Storb R, Giblett ER Transplantation of marrow from an unrelated donor to a patient with acute leukemia. N Engl J Med 1980; 303:565-567
10. Gordon-Smith EC, Fairhead SM, Chipping PM, Bone-marrow transplantation for severe aplastic anaemia using histocompatible unrelated volunteer donors. BMJ 1982; 285:835-837
11. Duquesnoy RJ, Zeevi A, Marrari M, Hackbarth S, Camitta B Bone marrow transplantation for severe aplastic anemia using a phenotypically HLA-identical, SB-compatible unrelated donor. Transplantation 1983; 35:566-571
12. Hows JM, Yin JL, Marsh J, Histocompatible unrelated volunteer donors compared with HLA nonidentical family donors in marrow transplantation for aplastic anemia and leukemia. Blood 1986; 68:1322-1328
13. Howard MR, Hows JM, Gore SM, Unrelated donor marrow transplantation between 1977 and 1987 at four centers in the United Kingdom. Transplantation 1990; 49:547-553
14. McGlave P, Scott E, Ramsay N, Unrelated donor bone marrow transplantation therapy for chronic myelogenous leukemia. Blood 1987; 70:877-881
15. Gingrich RD, Ginder GD, Goeken NE, Allogeneic marrow grafting with partially mismatched, unrelated marrow donors. Blood 1988; 71:1375-1381
16. Bacigalupo A, Hows J, Gordon-Smith EC, Bone marrow transplantation for severe aplastic anemia from donors other than HLA identical siblings: a report of the BMT Working Party. Bone Marrow Transplant 1988; 3:531-535
17. Camitta B, Ash R, Menitove J, Bone marrow transplantation for children with severe aplastic anemia: use of donors other than HLA-identical siblings. Blood 1989; 74:1852-1857
18. McGlave PB, Beatty P, Ash R, Hows JM Therapy for chronic myelogenous leukemia with unrelated donor bone marrow transplantation: results in 102 cases. Blood 1990; 75:1728-1732 [Erratum, Blood 1990;76:654.]
19. Mackinnon S, Hows JM, Goldman JM, Bone marrow transplantation for chronic myeloid leukemia: the use of histocompatible unrelated volunteer donors. Exp Hematol 1990; 18:421-425
20. Gajewski JL, Ho WG, Feig SA, Hunt L, Kaufman N, Champlin RE Bone marrow transplantation using unrelated donors for patients with advanced leukemia or bone marrow failure. Transplantation 1990; 50:244-249
21. Ash RC, Casper JT, Chitambar CR, Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors. N Engl J Med 1990; 322:485-494
22. Beatty PG, Hansen JA, Longton GM, Marrow transplantation from HLA-matched unrelated donors for treatment of hematologic malignancies. Transplantation 1991; 51:443-447
23. McCullough J Bone marrow transplantation from unrelated volunteer donors: summary of a conference on scientific, ethical, legal, financial, and other practical issues. Transfusion 1982; 22:78-81
24. McCullough J, Rogers G, Dahl R, Development and operation of a program to obtain volunteer bone marrow donors unrelated to the patient. Transfusion 1986; 25:315-323
25. McElligott MC, Menitove JE, Aster RH Recruitment of unrelated persons as bone marrow donors: a preliminary experience. Transfusion 1986; 26:309-314
26. Bradley B, Bidwell JL, Jarrold EA, Goffin RB, Klouda PT HLA matched unrelated bone marrow transplants: a proposal to speed up donor selection using a DNA bank. Bone Marrow Transplant 1986; 1:146-147
27. Raffoux C, Gluckman E, Busson M, Prevost P Development of a national volunteer donor's file for bone marrow transplantation. Bone Marrow Transplant 1988; 3: Suppl I: 163-164
28. Beatty PG, Dahlberg S, Mickelson EM, Probability of finding HLA-matched unrelated marrow donors. Transplantation 1988; 45:714-718
29. McCullough J, Hansen J, Perkins H, Stroncek D, Bartsch G. Establishment of the National Bone Marrow Donor Registry. In: Gale RP, Champlin RE, eds. Bone marrow transplantation: current controversies. Vol. 91 of UCLA Symposia on Molecular and Cellular Biology, new series. New York: Alan R. Liss, 1989:641-58.
30. Hopkins KA. Basic microlymphocytotoxicity test. In: Zachary AA, Teresi GA, eds. Laboratory manual. 2nd ed. Lenexa, Kans.: American Society for Histocompatibility and Immunogenetics, 1990:195-201.
31. Glucksberg H, Storb R, Fefer A, Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974; 18:295-304
32. Kaplan EL, Meier P Nonparametic estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-481
33. Mantel N Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966; 50:163-170
34. Cox DR Regression models and life-tables. J R Stat Soc [B] 1972; 34:187-220
35. O'Reilly RJ, Brochstein J, Dinsmore R, Kirkpatrick D Marrow transplantation for congenital disorders. Semin Hematol 1984; 21:188-221
36. Brochstein JA, Kernan NA, Groshen S, Allogeneic bone marrow transplantation after hyperfractionated total-body irradiation and cyclophosphamide in children with acute leukemia. N Engl J Med 1989; 317:1618-1624
37. Santos GW, Kaizer H Bone marrow transplantation in acute leukemia. Semin Hematol 1982; 19:227-239
38. Storb R, Thomas ED, Buckner CD, Marrow transplantation for aplastic anemia. Semin Hematol 1984; 21:27-35
39. Appelbaum FR, Barrall J, Storb R, Bone marrow transplantation for patients with myelodysplasia: pretreatment variables and outcome. Ann Intern Med 1990; 112:590-597
40. Powles RL, Morgenstern GR, Kay HEM, Mismatched family donors for bone-marrow transplantation as treatment for acute leukemia. Lancet 1983; 1:612-615
41. Beatty PG, Clift RA, Mickelson EM, Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med 1985; 313:765-771
42. Bozdech MJ, Sondel PM, Trigg ME, Transplantation of HLA-haploidentical T-cell-depleted marrow for leukemia: addition of cytosine arabinoside to the pretransplant conditioning prevents rejection. Exp Hematol 1985; 13:1201-1210
43. Cahn JY, Herve P, Flesch M, Marrow transplantation from HLA non-identical family donors for the treatment of leukaemia: a pilot study of 15 patients using additional immunosuppression and T-cell depletion. Br J Haematol 1988; 69:345-349
44. Kernan NA, Flomenberg N, Dupont B, O'Reilly RJ Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia: identification of host-derived antidonor allocytotoxic T lymphocytes. Transplantation 1987; 43:842-847
45. Anasetti C, Amos D, Beatty PG, Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med 1989; 320:197-204
46. Shapiro RS Epstein-Barr virus-associated B-cell lymphoproliferative disorders in immunodeficiency: meeting the challenge. J Clin Oncol 1990; 8:371-373
47. Sondel PM, Hank JA, Trigg ME, Transplantation of HLA-haploidentical T-cell-depleted marrow for leukemia: autologous marrow recovery with specific immune sensitization to donor antigens. Exp Hematol 1986; 14:278-286
48. Atkinson K, Farewell V, Storb R, Analysis of late infections after human bone marrow transplantation: role of genotypic nonidentity between marrow donor and recipient and of nonspecific suppressor cells in patients with chronic graft-versus-host disease. Blood 1982; 60:714-720
49. Bunin NJ, Casper JT, Chitambar C, Partially matched bone marrow transplantation in patients with myelodysplastic syndromes. J Clin Oncol 1988; 6:1851-1855
50. Ash RC, Horowitz MM, Gale RP, Bone marrow transplantation from related donors other than HLA-identical siblings: effect of T cell depletion. Bone Marrow Transplant 1991; 7:443-452
51. O'Reilly RJ, Collins NH, Kernan NA, Transplantation of marrow-depleted T cells by soybean lectin agglutination and E-rosette depletion: major histocompatibility complex-related graft resistance in leukemic transplant recipients. Transplant Proc 1985; 17:455-459
52. Trigg ME, Billing R, Sondel PM, Clinical trial depleting T lymphocytes from donor marrow for matched and mismatched allogeneic bone marrow transplants. Cancer Treat Rep 1985; 69:377-386
53. Choo SY, Antonelli P, Nisperos B, Nepom GT, Hansen JA Six variants of HLA-B27 identified by isoelectric focusing. Immunogenetics 1986; 23:24-29
54. Vasilov RG, Hahn A, Molders H, van Rood JJ, Breuning M, Ploegh HL Analysis of human class I antigens by two-dimensional gel electrophoresis. Immunogenetics 1983; 17:333-356
55. Neefjes JJ, Breur-Vriesendorp BS, van Seventer GA, Ivanyi P, Ploegh HL An improved biochemical method for the analysis of HLA-class I antigens: definition of new HLA-class I subtypes. Hum Immunol 1986; 16:169-181
56. Clay TM, Bidwell JL, Howard MR, Bradley BA PCR-fingerprinting for selection of HLA matched unrelated marrow donors. Lancet 1991; 337:1049-1052
57. Noreen HJ, Davidson ML, McCullough J, Bach FH, Segall M HLA class II typing by restriction fragment length polymorphism (RFLP) in unrelated bone marrow transplant patients. Transplant Proc 1989; 21:2968-2970
58. Baxter-Lowe LA, Eckels DD, Ash R, Casper J, Hunter JB, Gorski J Future directions in selection of donors for bone marrow transplantation: role of oligonucleotide genotyping. Transplant Proc 1991; 23:1699-1700
59. Angelini G, de Preval C, Gorski J, Mach B High-resolution analysis of the human HLA-DR polymorphism by hybridization with sequence-specific oligonucleotide probes. Proc Natl Acad Sci U S A 1986; 83:4489-4493 [Erratum, Proc Natl Acad Sci U S A 1986;83:6664.]
60. Tiercy JM, Morel C, Freidel AC, Selection of unrelated donors for bone marrow transplantation is improved by HLA class II genotyping with oligonucleotide hybridization. Proc Natl Acad Sci U S A 1991; 88:7121-7125
61. Buckner CD, Clift RA, Appelbaum FR, Effects of treatment regimens on post marrow transplant relapse. Semin Hematol 1991; 28:32-34
62. McGlave P Bone marrow transplants in chronic myelogenous leukemia: an overview of determinants of survival. Semin Hematol 1990; 27:23-30
63. Goldman JM, Gale RP, Horowitz MM, Bone marrow transplantation for chronic myelogenous leukemia in chronic phase: increased risk for relapse associated with T-cell depletion. Ann Intern Med 1988; 108:806-814
64. Clift RA, Buckner CD, Appelbaum FR, Allogeneic marrow transplantation in patients with chronic myeloid leukemia in the chronic phase: a randomized trial of two irradiation regimens. Blood 1991; 77:1660-1665
65. Weiden PL, Sullivan KM, Flournoy N, Storb R, Thomas ED, Seattle Marrow Transplant Team. Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. N Engl J Med 1981; 304:1529-1533
66. Sullivan KM, Weiden PL, Storb R, Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. Blood 1989; 73:1720-1728 [Erratum, Blood 1989;74:1180.]
67. Sanders JE, Whitehead J, Storb R, Bone marrow transplantation experience for children with aplastic anemia. Pediatrics 1986; 77:179-186
68. Casper JT, Truitt RR, Baxter-Lowe LA, Ash RC Bone marrow transplantation for severe aplastic anemia in children. Am J Pediatr Hematol Oncol 1990; 12:434-448
69. Gordon BG, Strandjord SE, Warkentin PI, Kadushin J, Coccia PF Successful treatment of severe aplastic anemia by bone marrow transplantation from HLA nonidentical family members: preliminary results utilizing cyclophosphamide and 600 cGY fractionated total body irradiation. Am J Pediatr Hematol Oncol 1991; 13:29-33
70. Champlin RE, Horowitz MM, van Bekkum DW, Graft failure following bone marrow transplantation for severe aplastic anemia: risk factors and treatment results. Blood 1989; 73:606-613
71. Longmore G, Guinan EC, Weinstein HJ, Gelber RD, Rappeport JM, Antin JH Bone marrow transplantation for myelodysplasia and secondary acute nonlymphoblastic leukemia. J Clin Oncol 1990; 8:1707-1714
72. De Witte T, Zwaan F, Gratwohl A, Timing of marrow transplantation in secondary leukemias and myelodysplastic syndromes. Transplant Proc 1989; 21:2958-2959
73. Guinan EC, Tarbell NJ, Tantravahi R, Weinstein HJ Bone marrow transplantation for children with myelodysplastic syndromes. Blood 1989; 73:619-622